PHOLPRINE SYRUP – Antitussive for children


Each 5 ml (teaspoonful) contains:

  • 1.4 mg Pholcodine
  • 2.0 mg Promethazine hydrochloride
  • 5.0 mg Phenylpropanolamine hydrochloride
  • 1.0 ml Balsam Tolu syrup

(in a palatable cherry flavoured vehicle)


A cough suppressant may occasionally be given in conjunction with an expectorant, the justification for these apparently antagonistic groups of drugs together has been stated to be that the tendency of cough suppressants to dry bronchial secretions is countered by the expectorant.

Pholprine presents pholcodine as a new cough suppressant with mild sedative action which relieves local irritation of the respiratory tract. It is used for the relief of unproductive cough.

Promethazine hydrochloride, a phenothiazine derivative, has prolonged antihistamine action, but its effect is slow in onset.

Phenylpropanolamine is a sympathomimetic agent with an action similar to ephedrine, but is somewhat more active as a vasoconstrictor and less active as a central nervous stimulant. Simply because pholprine decongests respiratory airways, reduces nasal irritation and relieves allergic interference without overstimulation or constipation, beneficial sedative effect ensures peaceful nights for the child.

Pholprine has a pleasant taste which is palatable for children.


  • Dry, irritating, useless cough of various aetiology.
  • To decongest, & soothe the respiratory mucosa in such conditions as common cold, influenza, sinusitis, otitis media, pharyngitis, etc.

Side effects

Excessive sedation or tachycardia occasionally may occur.


  • Hypertension,
  • Organic heart diseases.
  • Respiratory depression.
  • Acute asthma.
  • Glaucoma
  • and children under 3 years.


To be used with caution in asthmatic pts.& in the presence of excessive sputum in the bronchial tree.

Drug interactions

Due to phenylpropanolamine

  • Potentiated hypertension may occur with: Other sympathomimetics (present in many cold & cough remedies).
  • Beta-adrenergic blockers:¬†Hypotensive effect of antihypertensives may be inhibited.
  • Reversal bronchospasm may occur with Beta-adrenergic blockers.
  • Cardiac arrhythmias may occur with digitalis glycosides.

Due to promethazine hydrochloride

  • Excessive sedation may occur with other CNS depressants.


To be given 3-4 times daily or according to the physician’s directions.

  • 3-6 years: 1¬† teaspoonful.
  • 6 years & over: 2 teaspoonful.

PHOLPRINE SYRUP produced by Misr Pharmaceuticals, Cairo, Egypt.