Neurazine: Tranquilizer – Antiemetic

Chlorpromazine Hydrochloride – Injection – Tablets – Drops – Suppositories

Composition

Chlorpromazine Hydrochloride

• Injection: 25mg / 1ml, 50mg / 2ml
• Tablets: 25mg, 100mg / Tablet
• Drops: 4% Solution (Each drop contains approximately 1mg)
• Suppositories: 25mg / Suppository (containing Chlorpromazine base)

Therapeutic Effect

Neurazine (Chlorpromazine Hydrochloride – Misr) is a potent medication capable of creating a state of tranquility and reduced motor activity at doses that do not induce sleep. It inhibits the central vomiting center, regulates body temperature, and enhances the effectiveness of analgesic medications.

Indications

• Tranquilizer for nervous tension associated with certain neurological and psychological disorders.
• Antiemetic for vomiting associated with uremia, gastroenteritis, diabetes mellitus, and nausea and vomiting resulting from the use of certain medications, treatment of hiccups, sunstroke, and severe itching.

Contraindications

• Hypersensitivity to phenothiazines.
• Do not use in cases of coma or in the presence of large amounts of central nervous system depressants (alcohol, barbiturates, and narcotics) and treatment of bone marrow tumors.

Side Effects

Extrapyramidal symptoms may occur as a secondary effect of using thioridazine, including:

• Parkinsonian-like symptoms.
• Dystonia.
• Akathisia.
• Dyskinesia.

Side effects are dose-dependent and include low blood pressure and impaired body temperature regulation, which may lead to serious side effects in the elderly.

Other Side Effects:

• Drowsiness, apathy, tension, agitation, insomnia, convulsions, dizziness, headache, gastrointestinal disturbances, cardiovascular symptoms (such as high blood pressure, increased heart rate, and irregular heartbeats).
• Hormonal disturbances.
• Blood cell disorders.

Note: Intramuscular injection of this medication may be painful and may cause an increase in blood pressure and heart rate.

Precautions

Avoid most psychiatric medications during pregnancy unless absolutely necessary, and breastfeeding is not recommended during treatment.

Patients are advised not to drive or operate machinery during the first few days of Neurazine treatment.

Use with caution in the following cases: the elderly, debilitated patients, patients with a history of liver and bile disorders, in the presence of leukopenia, arteriosclerosis, cardiovascular diseases, or other conditions in which a sudden drop in blood pressure is undesirable.

Do not use antipsychotic drugs to treat dementia-related psychosis.

Because elderly patients with dementia-related psychosis who are treated with antipsychotic drugs are at an increased risk of death.

Use During Pregnancy

Non-teratogenic effects

Newborn infants exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery. There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder in these infants. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases infants have required intensive care unit support and prolonged hospitalization.

Chlorpromazine hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Dosage

• Treatment of nervous and psychiatric disorders: 75-500 mg daily in divided doses.
• Treatment of vomiting and other cases: 25-50 mg three times daily.
• Children over 5 years: one-third to one-half the adult dose daily.
• Children under 5 years: 1-2 mg per kg of body weight daily.

Presentation

• Injections: Box of 6, 100 ampoules.
• Tablets: Box of 20 tablets.
• Drops: Bottle of 10 ml.
• Suppositories: Box of 5 suppositories.

Important Note

This medication is a medicinal product that affects your health, and consumption contrary to instructions poses a risk.

• Follow the doctor’s prescription and the instructions provided by the pharmacist who dispensed it carefully.
• Do not discontinue the treatment period prescribed for you on your own.
• Do not take the medication again except under the instructions of the doctor.
• Keep medicines out of the reach of children.

Council of Arab Health Ministers and the Arab Pharmacists Union.
Misr Company for Pharmaceutical Industries.
Keep out of reach of children.