Mucophylline Syrup – Mucolytic, Bronchodilator

Composition

Each teaspoonful (5ml) contains:

• 4 mg Bromhexine hydrochloride
• 100 mg Acephylline piperazine

Properties

Mucophylline acts on the bronchial tree clearing it from the viscid sputum and relaxing its constricted muscles providing an efficient symptomatic treatment in most respiratory ailments through the action of its two active ingredients.

Bromhexine hydrochloride is a mucolytic agent which acts by depolymerization of the mucopolysaccharide ground substance of the sputum increasing its fluidity so facilitates its expectoration and consequently minimizes the intensity and frequency of cough.

Acephylline piperazine. The other active ingredient in MUCOPHYLLINE is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and by producing minimal gastric irritation.

Indications and usage

Cough specially when associated with bronchospasm in such conditions as: asthma, emphysema, acute & chronic bronchitis, chronic inflammatory lung diseases, inhalation of irritants, etc.

To facilitate expectoration of contrast media or other abnormal fluids from the bronchial tree.

Contra-indications

• Hypersensitivity to xanthines.
• Severe renal or hepatic impairment.
• Gastritis and active peptic ulcer.
• Rapid cardiac arrythmias, and acute coronary heart disease when myocardial stimulation might be harmful.

Side effects

Occasionally occur in the form of one or more of the following:

• Gastrointestinal disturbance: epigastric pain, nausea, vomiting, diarrhea.
• C.N.S stimulation – irritability (specially in children), Nervousness, insomnia, headache.
•  Palpitations, tachycardia, extrasystoles.
• Tachypnea,
• Transient urinary frequency.

Drug interactions

•  Xanthine derivatives may Produce excessive C.N.S stimulation when given with ephedrine or other sympathomimetics specially in children (in the very youngs convulsions may occur).
• Enhance the toxicity of digitalis glycosides.
• The bronchodilator action of xanthines may be antagonized by beta-adrenergic blockers & reduced by smoking.
• Tachycardia may occur when xanthines are given with reserpine or sympathomimetics.
• Increased serum levels and effects of theophylline derivatives may occur with erythromycin, lincomycin, clindamycin and possibly with allopurinol.

Warnings & Precautions

• Avoid over dosage in children specially young ones.
• Use with caution in cases of: compromised cardiac or circulatory function, Hyperthyroidism, prostatic hypertrophy, peptic ulcer, glaucoma, diabetes, severe hypertension, and in nursing mothers.
• Keep out of the reach of children.

USE IN PREGNANCY

Safety not established.

Dosage and administration

• Adults: 2 teaspoonfuls three times per day. (to be taken after meals).
• Children: – Over 10 years: 2 teaspoonfuls three times per day. (to be taken after meals).
• 5-10 years: 1 teaspoonful three times per day. (to be taken after meals).
• 1-5 years: ½ teaspoonful three times per day. (to be taken after meals).

ميوكوفللين شراب – مذيب للبلغم ، موسع قصبي

Mucophylline Syrup produced by Misr Pharmaceuticals, Cairo, Egypt.