Erythroprim Film coated Tablets – Dry Suspension

Erythroprim – Broad spectrum Antibacterial – Antibiotic


Each (film coated ) tablet contains : Erythromycin stearate equivalent to Erythromycin base 250 mg. Trimethoprim 80 mg.

Each 5 ml Contains: Erythromycin ethyl succinate equivalent To Erythromycin base 200 mg , Trimethoprim 40 mg.


Combination of erythromycin and trimethoprim broadens the antimicrobial spectrum and also it covers most gram negative and gram positive bacteria.

The combination also delays emergence of resistant strains. Erythroprim is quietly and completely absorbed after oral administration and metabolised in the liver and excreted in urine and faeces (Erythromycin is mainly excreted in bile, Trimethoprim is mainly excreted in urine up to 60% of the oral dose as unchanged drug).

Indications & Usage

  • Respiratory tract infections – ( upper and lower )
  • Gastro-enteritis.
  • Urinary tract infections.
  • E.N.T. infections (sinusitis and otitis media).
  • Other systemic infections caused by sensitive bacteria.
  • Chlamydial infections.
  • Spirochetal infections.
  • Anaerobic infections.

Side effects

Erythromycin – Infrequent and mild.

  • Gastrointestinal upset.
  • Allergic reactions in the form of skin rash

Trimethoprim – dose and course related.

  • Nausea, vomiting. allergy and fixed drug eruption.
  • Megaloblastic anaemia and reversible bone marrow depression.
  •  Very rare hyper-sensitivity reaction to any of therm.

Drug interactions


  • potentiate the effect of carbamazepin, corticosteroids and digoxin.
  • High and potentially toxic concentrations of theophyline may result when erythromycin is used concurrently.
  • Concurrent use of the following drugs is not recommended because competitive inhibition with erythromycin may occur: Lincomycin, clindamycin. Chlorarnphenicol.
  • Erythromycin may interfere with the bactericidal effect of penicillin.


  • potentiates the effect of warfarin.
  • increases side effects of other folic acid antagonizers.

Warnings and precautions

Erythroprim should not be used in:

  • known hypersensitivity to either drugs.
  • G.6P.D deficiency.
  • Pregnancy.

Dosage and administration

Erythroprim should be taken before meal with ½ – 1 hour.

Adult: two tablets twice daily ( 12 hourly ).

Children under 12 years: one tablet twice daily (12 hourly).

Infants up to 1 year: 25-50 mg/kg/wt/day/divided 12 hourly or ½ teaspoonful/12 hourly.

Over 1 year: 30-50 mg /kg/wt/day/ may be increased to 100 mg.

Or : 1 – 2 teaspoonful/ 12 hourly Or according to the physician prescription.


Erythroprim produced by Misr Pharmaceuticals, Cairo, Egypt.  Atc: J01FA01, J01EA01