COLI URINAL effervescent granules – Urinary antiseptic with antispasmodic


Each 100 gm contains:

  • 10gm Hexamine
  • 35 mg Khelline
  • 3 mg Piperazine Hexahydrate (as citrate)

Effervescent base add. 100 gm.


The antiseptic action of Coli-urinal depends mainly upon the presence of hexamine, which is in acid urine slowly hydrolysed to formaldehyde and ammonia. The peak concentration of formaldehyde is attained in 2 hours which acts as potent antiseptic that may be effective in some cases where other antibacterials fail (specially chronic cases).

Khellin by its direct relaxant action on the smooth muscles relieves the colic which usually associates urinary disorders. Piperazine adds to the benefit of Coli-urinal by increasing uric acid excretion and dissolving urate crystals.

Coli-urinal is readily absorbed from GIT and is rapidly eliminated in the urine.


Urinary tract infections: pyelitis, pyelonephritis, cystitis, uretheritis, etc.

May help as adjuvant in case of recurrent urate calculi.

Side Effects

In occasional patients slight nausea. Vomiting & diarrhea may occur and overdoses may rarely produce nervous complications including somnolence, dizziness, muscular incoordination due to piperazine specially in patients com- plaining of disturbances of renal function.


  • Impairment of hepatic function due to liberation of ammonia from hexamine in the gastrointestinal tract.
  • Severe or moderate renal failure. Severe dehydration, metabolic acidosis, neurological disturbances, epilepsy.

Drug interactions

Sulphathiazole (and may be sulfonamides) forms insolu- ble urinary crystals with formaldehyde, so avoid such combination with hexamine containing preparations.

Dosage and administration

Coli-urinal is better to be given after meals. 1 Tablespoonful in 1/2 glass of water three times per day.


  • To be stored at temp. not exceeding 25 °C
  • To be stored at a cool dry place away from heat and light.

COLI URINAL effervescent granules produced by Misr Pharmaceuticals, Cairo, Egypt.