Zeta-Cort Cream: Comprehensive Patient Information

Zeta-Cort Cream is a topical medication that combines the antibacterial power of fusidic acid with the anti-inflammatory and antipruritic properties of betamethasone valerate. This cream is primarily used for treating inflammatory skin conditions that are accompanied by bacterial infections.

Composition

Each 100 g of Zeta-Cort Cream contains:

• Fusidic Acid 2 g
• Betamethasone Valerate (equivalent to Betamethasone 0.1 g)

Excipients:

• Propylene glycol
• Cetomacrogol
• Mineral oil
• Cetostearyl alcohol
• Paraffin
• Potassium sorbate
• Sodium phosphate
• Phosphoric acid

Properties

Zeta-Cort Cream combines two active ingredients:

1. Fusidic Acid: An antibiotic derived from Fusidium coccineum, effective against various bacteria including Staphylococcus, Streptococcus, Corynebacteria, Neisseria, and certain strains of Clostridia and Bacteroides. The antibacterial action works by inhibiting bacterial protein synthesis.
2. Betamethasone Valerate: A potent topical corticosteroid that provides rapid relief in inflammatory skin conditions.

Indications

Zeta-Cort Cream is indicated for inflammatory dermatoses [skin conditions involving inflammation] that are associated with bacterial infections, including:

• Atopic eczema [a chronic skin condition causing itchy and inflamed skin]
• Discoid eczema [a skin condition characterized by circular, itchy patches]
• Stasis eczema [eczema due to poor blood circulation]
• Seborrheic dermatitis [a skin condition causing scaly patches and redness, usually on the scalp]
• Contact dermatitis [skin inflammation due to allergens or irritants]
• Lichen simplex chronicus [thickened skin caused by repeated scratching or rubbing]
• Psoriasis [a chronic autoimmune skin disorder causing scaling and inflammation]
• Discoid lupus erythematosus [a form of lupus affecting the skin with red, scaly patches]

Contraindications

Do not use Zeta-Cort Cream if you have a known hypersensitivity [allergic reaction] to any of its components. Additionally, topical corticosteroids should not be used in the following conditions:

• Viral skin infections (e.g., herpes simplex, chickenpox)
• Tuberculous skin infections [skin conditions caused by Mycobacterium tuberculosis]
• Fungal skin infections (e.g., ringworm, candidiasis)
• Perioral dermatitis [a rash around the mouth]
• Acne rosacea [a chronic skin condition causing redness and visible blood vessels]
• Ulcerative skin conditions

Precautions

• Avoid excessive use of topical steroids during pregnancy.
• Use caution when applying on large areas, flexures [skin folds], or intertriginous areas [where two skin surfaces touch].

Warnings

• Long-term continuous therapy should be avoided, especially on the face, skin folds, and in infants and children.

Dosage and Administration

For uncovered lesions:

• Apply Zeta-Cort Cream 2-3 times daily.

For covered lesions:

• Less frequent application may be adequate.

Side Effects

Like other topical corticosteroids, prolonged and intensive use of Zeta-Cort Cream may cause:

• Local atrophic changes [thinning of the skin]
• Rare hypersensitivity reactions [allergic skin reactions]

If any side effects occur, consult a pharmacist or physician immediately.

Pharmaceutical Precautions

• Store at room temperature (15-30°C).
• For external use only.
• Do not ingest.
• Do not use beyond the expiry date or if the product shows signs of deterioration.

Presentation

Zeta-Cort Cream is available in 15 g aluminum tubes.

Important Patient Information

• This is a medicinal product that affects your health. Using it improperly can be dangerous.
• Follow your doctor’s prescription and pharmacist’s instructions strictly.
• Your doctor and pharmacist are knowledgeable about the benefits and risks of this medication.
• Do not stop treatment without consulting your doctor.
• Do not reuse the prescription without a doctor’s approval.
• Keep out of reach of children.

Regulatory Information

This leaflet follows the guidelines of the Council of Arab Health Ministers and the Union of Arab Pharmacists.

Manufacturer Details

TABUK PHARMACEUTICAL MANUFACTURING COMPANY P.O. Box 3633, TABUK, SAUDI ARABIA.

Conclusion

Zeta-Cort Cream is an effective combination treatment for inflammatory dermatoses with bacterial infections. Proper usage, as per a healthcare provider’s recommendation, ensures its benefits while minimizing risks. Always consult a doctor or pharmacist if you have concerns about its use.