Urosolvine: Your Guide to Managing Urolithiasis and Gouty Arthritis

Understanding Urosolvine Effervescent Granules

Composition:

Each 5g sachet of Urosolvine contains:

  • Active Ingredients:
  • Piperazine Citrate: 0.1408g (Equivalent to 0.128g Piperazine Hydrate)
  • Colchicine Crystals: 0.3mg
  • Atropine Sulphate: 0.128mg
  • Inactive Ingredients:
  • Sodium Bicarbonate
  • Citric Acid Anhydrous
  • Tartaric Acid
  • P.V.P (Polyvinylpyrrolidone)
  • Lemon Oil
  • Sucrose

Pharmaceutical Form:

Effervescent Granules

Pharmacotherapeutic Group:

Uricosuric

Unraveling the Pharmacological Action

How Urosolvine Works:

  • An acute attack of gout is often linked to an increase in uric acid concentration, leading to the deposition of monosodium urate in joint tissues.
  • Piperazine, known for its efficacy in treating gout and urinary lithiasis, enhances the solubility of urates in urine without significant toxicity.
  • Colchicine, a specific drug for gouty arthritis, provides rapid relief from pain and possesses anti-inflammatory properties. It interferes with the inflammatory response to urate crystal deposition by inhibiting neutrophil migration.
  • Atropine Sulphate is included to relieve urinary tract spasm.

Understanding Pharmacokinetics

Urosolvine’s Action in the Body:

  • Urosolvine acts as a uricosuric agent, promoting the urinary excretion of uric acid and lowering serum uric acid concentration.
  • Sodium citrate, an alkalinizing agent in Urosolvine, contributes to urine alkalinity, making it more suitable for the excretion of urates in a soluble form.

Indications: When to Use Urosolvine

Conditions Urosolvine Addresses:

  • Acute and chronic gout
  • Gouty arthritis
  • Prophylaxis against urinary lithiasis (urate stones)

Dosage and Administration: Taking Urosolvine Effectively

Proper Usage Guidelines:

  • In Acute Attack: Dissolve one sachet in half a glass of water six times daily.
  • To Prevent Acute Attack: Dissolve two sachets in a glass of water twice daily.
  • As Prophylaxis: Dissolve two sachets in a glass of water once daily.

Contraindications: When Not to Use Urosolvine

Situations to Avoid Urosolvine:

  • Known hypersensitivity to any components of the drug.
  • Blood dyscrasias
  • Acute dehydration, anuria, or hyperkalemia

Potential Side Effects and Precautions

What to Watch Out For:

  • Side Effects: Occasionally, nausea, vomiting, abdominal pain, and diarrhea may occur.
  • Precautions: Use with caution in patients with serious gastrointestinal, renal, hepatic, and cardiovascular disorders. Avoid use in children, geriatrics, debilitated patients, and nursing women.

Package and Storage

Keeping Urosolvine Safe:

  • Package: Carton box of 12 Sachets X 5g + inner leaflet.
  • Storage: Store at a temperature not exceeding 25°C in a dry place.

Patient Instructions

Tips for Patients:

  • Dosage Adjustment: Reduce dosage if vomiting or diarrhea occurs.

In conclusion, Urosolvine Effervescent Granules offer a targeted solution for managing urolithiasis and gouty arthritis. Understanding its composition, pharmacological action, and proper usage guidelines empowers patients to use it effectively. Always consult healthcare professionals for personalized advice, and adhere to precautions for a safe and beneficial experience with Urosolvine.