Understanding ATRIPLA: Your Comprehensive Guide

Atripla® is a combination medication used to treat HIV-1 infection in adults and children aged 12 years and older who weigh at least 40 kg. It is crucial to be well-informed about this medicine before you begin your treatment. This guide provides an overview of Atripla, including its composition, uses, possible side effects, and essential precautions.

What is ATRIPLA?

Atripla is a combination medication that includes three active ingredients:

  • Efavirenz (SUSTIVA® or STOCRIN®)
  • Emtricitabine (EMTRIVA®)
  • Tenofovir disoproxil fumarate (VIREAD®)

These components work together to combat HIV-1 (human immunodeficiency virus). Efavirenz is classified as an HIV-1 non-nucleoside analogue reverse transcriptase inhibitor (NNRTI), while Emtricitabine and Tenofovir disoproxil fumarate are HIV-1 nucleoside analogue reverse transcriptase inhibitors (NRTIs).

How Does ATRIPLA Work?

HIV infection can lead to the destruction of CD4+ T cells, which play a vital role in our immune system. Atripla helps by blocking HIV-1 reverse transcriptase, an enzyme necessary for the virus’s multiplication. As a result, Atripla reduces the viral load in your blood and increases the number of T cells (CD4+ cells), thereby enhancing your immune system. Atripla does not cure HIV-1 or AIDS, but it effectively manages the infection, lowering the risk of opportunistic infections.

What You Should Know

  • Who Should Not Take Atripla: Individuals allergic to any of its components (Efavirenz, Emtricitabine, and Tenofovir DF) should avoid Atripla.
  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant or planning to become pregnant. Breastfeeding is not recommended while taking Atripla.
  • Kidney and Liver Health: Discuss your kidney and liver health with your healthcare provider as certain conditions may require special attention.
  • Mental Health and Seizures: Inform your healthcare provider if you have a history of mental illness or seizures.

Interactions with Other Medications

Atripla may interact with other medications, so it’s essential to inform your healthcare provider about all the drugs, herbal supplements, or vitamins you are taking.

Medicines You Should Not Take with ATRIPLA

Do not take Atripla with specific medicines, including Combivir, Sustiva, and Stocrin, unless recommended by your healthcare provider. The antifungal medication Vfend should also be avoided while taking Atripla. Additionally, Atripla should not be used with Hepsera (adefovir dipivoxil).

How to Take Atripla

  • Always follow your healthcare provider’s prescription. Do not change the dosage on your own or stop taking the medicine without consulting your healthcare provider.
  • Take Atripla on an empty stomach with water.
  • Swallow the pill whole.
  • If you miss a dose, take it as soon as you remember. Do not double the next dose. Continue with your regular dosing schedule.
  • Keep an ample supply of Atripla to prevent interruptions in your treatment.

What to Avoid While Taking Atripla

  • Pregnant women should avoid Atripla and use effective contraception.
  • Atripla may cause dizziness, so avoid activities that require focus, such as driving.
  • Do not consume alcohol or medications with similar side effects while taking Atripla.
  • Inform your healthcare provider before starting any new medications.

Possible Side Effects

Atripla may lead to some common side effects, such as dizziness, headache, drowsiness, and unusual dreams. These side effects tend to subside after a few weeks. If they persist or become bothersome, contact your healthcare provider. Other possible side effects include:

  • Flare-ups of Hepatitis B
  • Lactic acidosis
  • Severe liver problems
  • Serious psychiatric issues
  • Kidney problems
  • Changes in bone mineral density
  • Rash
  • Tiredness, upset stomach, vomiting, gas, and diarrhea
  • Changes in body fat
  • Skin discoloration
  • Inflammatory symptoms

Contact your healthcare provider before discontinuing Atripla due to side effects or any other reasons. This is not an exhaustive list, so consult your healthcare provider for comprehensive information on Atripla’s side effects.


  • Keep Atripla and all medications out of reach of children.
  • Store Atripla at or below 30 °C.
  • Keep Atripla in its original container, tightly closed.
  • Dispose of any outdated or unneeded medications safely.


Atripla is a powerful tool in the management of HIV-1 infection, but it must be taken with caution and under medical supervision. Stay informed, adhere to your healthcare provider’s advice, and maintain open communication to ensure the most effective and safe treatment. If you have any questions about Atripla, your healthcare provider or pharmacist can provide further guidance.

Please note that this article is for informational purposes only and does not replace professional medical advice. Consult your healthcare provider for personalized guidance on your treatment.

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