Timogen (Tiemonium Methylsulphate) is an antispasmodic drug that reduces muscles spasm of the intestine, biliary system, bladder and uterus. Timogen (Tiemonium Methylsulphate) is used in symptomatic treatment of pain related to functional disorders of the digestive tract and biliary system. It is also indicated for the treatment of spasm and pain in urological and gynaecological diseases.

Composition

• 120 ml bottle contains: Tiemonium methylsulphate : 240 mg .
• Each 5 ml contains 10 mg Tiemonium methylsulphate.

Pharmacological Properties

• Tiemonium : Mixed antispasmodic.
• Musculotropic.
• Anticholinergic ( 1/50 th of the effect of atropine at atropine molar concentration ).

Pharmacokinetic Properties

Oral route : half-life of absorption : 36 min, apparent half-life of elimination :3 hr 24 min. Maximum plasma concentration in 2 hr, total excretion in 72 hr (fecal excretion 70 % in 72 hr, urinary : 8 % in 24 hr, also by respiratory and cutaneous routes ).

Indications

• Symptomatic treatment of pain related to functional disorders of the digestive tract and biliary system.
• Treatment Of spasm and pain in the urinary tract and in gynaecology.

Contraindications

• Urethroprostatic disorders involving a risk of urine retention .
• Risk of angle-closure gloucoma.

Pregnancy and breast-feeding

• The results of animal studies of tiemonium did not reveal any teratogenic effects. Although these results do not prejudge the effects in man . no deformities have been reported up till now with normal use .
• In the absence of sufficient data prudence should be the rule for nursing mothers although no problems were reported with normal use

Dosage and method of administration

The usual dosage of TIMOGEN is:

• For childern dosage :3 teaspoonfuls / 5 kg body weight / day .
• For adults : 1 to 3 tablespoonfuls, 3 times a day .

Presentation

• bottle containing 120 ml.
• Storage: keep at temp. not exceeding 30°c in adry place.
• To be used under medical supervision.
• Keep out of reach of children.
• Produced by DELTA PHARMA S.A.E Tenth of Ramadan City , A.R.E.

Timogen – Information Leaflet

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