Rheumarene 75 mg Injection
A comprehensive guide to the injection for severe and acute pain and inflammation.
Quick Facts
Diclofenac Sodium
Within 15-30 minutes
Deep intramuscular injection
Risk to heart and kidneys
Avoid in third trimester
Very short (2 days max)
What is Rheumarene Injection and What is it Used For?
Rheumarene injection is a potent pharmaceutical form from the family of nonsteroidal anti-inflammatory drugs (NSAIDs), containing the active ingredient “Diclofenac Sodium.” These injections are used to provide rapid and effective relief for acute, moderate-to-severe pain, especially when taking medication orally is not possible or appropriate. The injection works by preventing the production of chemicals that cause pain and inflammation in the body.
These injections are administered only by medical professionals in situations requiring rapid pain control.
- Post-operative pain: To control severe pain after surgical procedures.
- Renal colic: To relieve the acute pain caused by kidney stones.
- Acute arthritis attacks: Such as gout or rheumatoid arthritis flare-ups.
- Severe back pain and acute injuries.
Method of Administration and Dosage
Rheumarene injection is given exclusively by deep intramuscular injection and must be administered by a qualified doctor or nurse. It is usually injected into the buttock muscle (gluteal region). It is crucial to avoid injecting it into a blood vessel to ensure patient safety. This medication is not intended for self-administration at home.
The usual adult dose is one ampoule (75 mg) once daily. In severe cases, a second injection may be given on the same day, but it must be in the opposite side of the body and with a time interval of at least several hours. Treatment with injections should be short-term, for a maximum of two days, after which a switch to oral tablets should be made if necessary.
Potential Side Effects
Rheumarene injections can cause side effects, some of which are local to the injection site and others systemic, affecting the whole body.
- Common local effects: Pain, hardening, redness, or swelling at the injection site.
- Common systemic effects: Nausea, headache, dizziness, and stomach upset.
- Serious effects (rare): Severe allergic reaction (anaphylactic shock), sudden chest pain, breathing problems, or signs of tissue damage at the injection site.
The doctor should be informed immediately of any severe or persistent pain at the injection site or any of the serious side effects.
Important Warnings and Precautions
Like the oral forms, Rheumarene injections carry warnings of an increased risk of cardiovascular disease (heart attack and stroke) and gastrointestinal problems (ulcers and bleeding). The doctor must be informed of the full medical history before the injection is received.
- It is contraindicated in patients with an active ulcer, or severe heart, kidney, or liver failure.
- It should not be used in patients who are allergic to aspirin or other NSAIDs.
- Extreme caution should be used when given to asthma patients, as it may trigger a severe asthma attack.
- It is strictly prohibited in the third trimester of pregnancy.
About the Manufacturer: SEDICO
This product is manufactured by “SEDICO,” the South Egypt Drug Industries Company, one of the leading firms in the Egyptian pharmaceutical sector. Since its establishment in 1990, “SEDICO” has been committed to applying the highest international quality standards and current Good Manufacturing Practices (cGMP) to ensure the safety and efficacy of its products.
The company is known as a pioneer in biotechnology in the region, having been the first to produce human insulin and growth hormone. With its diverse pharmaceutical portfolio covering many therapeutic areas, “SEDICO” has become a trusted brand among doctors and patients in Egypt and many countries in the Middle East and Africa.
More information and contact with SEDICO: Please visit the following link
Frequently Asked Questions about Rheumarene Injection
1. Why are injections used instead of tablets?
Rheumarene injections are used for two main reasons: first, to provide faster pain relief, as the drug reaches the bloodstream directly and starts working within 15-30 minutes, which is much faster than tablets. This is vital in cases of severe pain like renal colic or post-operative pain.
Second, injections are used for patients who cannot take medication orally, such as those with severe nausea and vomiting, unconscious patients, or before and after some surgical procedures. Once the patient is able to eat, they are switched to oral therapy.
2. Is the injection painful?
Like any intramuscular injection, the patient may feel a slight sting and pain during the injection itself. It is also common to feel some pain or stiffness in the muscle at the injection site for a few hours or a day afterward. This is usually normal and resolves on its own.
However, if the pain at the injection site is very severe, lasts for more than two days, or you notice significant swelling, redness, or pus, you should contact your doctor immediately, as these could be signs of complications like an abscess or tissue damage.
3. How long can I use Rheumarene injections?
Treatment with Rheumarene injections is designed to be very short-term. Medical recommendations stress that the injections should not be used for more than two consecutive days. The goal is to control acute pain quickly and then switch to another form of treatment (usually tablets or suppositories) once the patient’s condition has stabilized.
Prolonged use of injections increases the risk of problems at the injection site, in addition to increasing systemic risks to the heart, stomach, and kidneys. Your doctor will determine the most appropriate treatment plan for your condition to ensure efficacy and safety.
4. Who should administer this injection?
Rheumarene injections must be administered exclusively by a qualified healthcare professional, such as a doctor or nurse. Deep intramuscular injection requires precise anatomical knowledge to avoid injuring large nerves (like the sciatic nerve) or blood vessels. Incorrect injection can cause severe pain, nerve damage, or the formation of an abscess.
Never attempt to inject yourself or allow an untrained person to give you this injection. It should always be received in a medical clinic, hospital, or healthcare center equipped to handle any emergency that may arise.
5. Can Rheumarene injections be used for sciatica pain?
Yes, Rheumarene injections can be used to relieve the severe, acute pain caused by sciatica (inflammation of the sciatic nerve). Since sciatica often involves inflammation and pressure on the nerve, the dual action of the drug as an anti-inflammatory and analgesic makes it effective in controlling acute episodes.
However, the injection is just one part of the treatment. Once the acute pain is controlled, a comprehensive treatment plan should be followed, including rest, physical therapy, and sometimes other medications to address the root cause of the problem. Injections alone are not a permanent cure.
6. Do Rheumarene injections interact with blood thinners?
Yes, there is a significant and important interaction. NSAIDs, including Rheumarene, have a mild anticoagulant effect. When taken with blood thinners (like warfarin) or antiplatelet drugs (like aspirin or clopidogrel), they significantly increase the risk of bleeding.
Patients taking blood thinners must inform their doctor before receiving a Rheumarene injection. The doctor may decide that the risk outweighs the benefit, or it may require close monitoring of blood coagulation levels. Do not receive this injection if you are taking these medications without explicit medical approval.
7. Does the injection cause drowsiness?
Drowsiness and dizziness are potential side effects of Rheumarene injections, although they are not as common as stomach problems. Some people may feel dizzy or unbalanced after receiving the injection. This effect may be more pronounced in the elderly.
For this reason, it is advisable to avoid driving, operating heavy machinery, or doing any activities that require full mental focus after receiving the injection until you are sure you are not experiencing these side effects. It is best to have someone drive you home after receiving the shot.
8. Can it be used for children?
Rheumarene 75 mg injections are not recommended for children and adolescents. This concentration is typically intended for adults. Pediatric doses require precise calculations based on weight and age, and there are other medications and concentrations that are more suitable and safer for use in this age group.
The recommendations of a pediatrician should always be followed when treating pain in children. Adult medications should not be given to children without specialized medical consultation, as this could lead to overdoses and serious complications.
9. Does Rheumarene injection raise blood sugar levels?
In general, NSAIDs like Rheumarene do not directly cause a rise in blood sugar levels. However, diabetic patients should exercise caution. These medications can affect kidney function, which is already a common issue for people with diabetes.
Additionally, NSAIDs can interact with some oral diabetes medications. Therefore, diabetic patients should always consult their doctor before using Rheumarene injections to ensure it is safe for their condition and will not interfere with their treatment plan.
10. What happens if Rheumarene is accidentally injected into a vein?
Rheumarene injection is designed for intramuscular injection only and must not be injected into a vein. Accidental intravenous injection can cause a sudden and sharp drop in blood pressure (shock), as well as severe irritation to the vein. This is an emergency that requires immediate medical intervention.
This re-emphasizes the importance of the injection being administered by a trained medical professional who can ensure the needle is in the correct location (the muscle) before injecting the drug. Safety is the top priority when dealing with injectable medications.
Medical Disclaimer
The information contained in this article is for educational purposes only and should not be considered a substitute for professional medical advice. Do not diagnose or treat any health condition on your own. Always consult your doctor or pharmacist before starting any new medication or making any changes to your treatment plan. We assume no responsibility for any misuse of the information provided.
Dr. Ahmad Baker, PharmD
Senior Pharmacist & Health Educator
With over 23 years of clinical experience in hospital and community pharmacy across Egypt and Saudi Arabia, Dr. Ahmad specializes in reproductive health and pharmaceutical safety. He is dedicated to providing evidence-based guidance to empower patients in the MENA region.
Medical Disclaimer: This content is for educational purposes and reflects the latest pharmaceutical protocols. It is not a substitute for personal medical advice. Always consult Dr. Ahmad Baker or your healthcare provider before starting any treatment.

