Each tablet contains:
- Ergotamine tartrate: 1 mg.
- Paracetamol: 250 mg.
- Caffeine anhydrous: 50 mg.
- Domperidone: 10 mg.
No-Migrain® is a unique combination for the abortive treatment of migraine attacks.
Ergotamine tartrate, is an alpha adrenergic-blocking agent with a direct stimulating effect on the smooth muscles of the peripheral and cranial blood vessels. It has serotonin-antagonist properties.
It crosses the blood brain barrier and is excreted in breast milk.
It may inhibit prolactin secretion.
It is effective in 80-90% of patients, if taken during prodrome or immediately after the onset of an attack.
Paracetamol, acts mainly centrally to reduce prostaglandin synthesis in the brain by inhibiting cyclo-oxygenase enzyme and this accounts for its analgesic effect.
Caffeine, enhances the ergotamine effect by being a cranial vasoconstrictor and, also potentiates the analgesic effect of paracetamol.
It has the ability to increase gastrointestinal tract absorption of ergotamine tartrate.
Domperidone, is a peripheral dopamine antagonist that controls nausea and vomiting by blocking the dopamine receptors in the chemoreceptor trigger zone.
- Abortive and/or preventive therapy for vascular headache.
- Migraine variants
- Histaminic cephalgia.
- During pregnancy
- Peripheral vascular diseases, coronary heart disease, and hypertension
- Hypersensitivity to any of the components
Signs and symptoms of ergotism rarely develop even after long term intermittent use, care should be exercised to remain within the limits of the recommended dosage.
- No-Migrain® should not be administered with other vasoconstrictors.
- Use with sympathomimetics may cause elevation of blood pressure.
Weakness of legs and pain in limb muscles, as well as numbness and tingling of fingers and toes may occasionally occur.
Dosage and Administration
For the best results, dosage should start at the first sign of an attack, since success is proportional to rapidity of treatment and lower doses will be effective.
Patients should be advised that two tables are to be taken at the first sign of a migraine headache; followed by one additional tablet every ½ hour if needed, up to six tablets per attack. Total weekly dosage should not exceed ten tablets.
Strips of 10 tablets in packs 1 or 2 strips.
Keep all medicaments out of reach of children
Product of: AMOUN PHARMACEUTICAL CO. El-Obour City, Cairo, Egypt. ATC Code: N02CA52 , N02BE01 , N06BC01 , A03FA03