Lamifen – Terbinafine: Broad Spectrum Antifungal

Lamifen tablet: is indicated for the treatment of:

  • Onychomycosis (fungal infection of the toenail or fingernail) due to dermatophytes (tinea unguium).
  • Tinea capitis
  • Fungal infections of the skin for the treatment of tineacorporis, tinea cruiris, tinea pedis & yeast infections of the skin caused by the genus Candida (e.g. Candida albicans) where oral therapy is generally considered appropriate.

Lamifen cream: is used to treat:

  • Fungal infections of the skin caused by dermatophytes such as: Trichophyton(e.g. tinea rubrum, tinea mentagrophytes, tinea verruccosum, tinea violaceum).
  • Microsporum canis and Epidemophyton floccosum.
  • Yeast infections of the skin e.g. Candida albicans.
  • Tinea versicolor.

Dosage and Administration

Lamifen tablet

  • Children: (No data are available in children under 2 years of age).
  • Children<20 Kg: 62.5mg once daily.
  • Children 20-40 Kg: 125 mg once daily.
  • Adults: 250 mg once daily.
  • Elderly: When prescribing tablet for elderly patients, the possibility of pre-existing impairment of liver or kidney function should be considered.

Recommended duration of treatment by tablet

Skin infections:

  • Tinea pedis: 2 to 6 weeks.
  • Tinea corporis, crusis: 2 to 4 weeks.
  • Cutaneous candidiasis: 2 to 4 weeks.

Complete healing process often takes several weeks after mycological cure.

Hair & scalp infections:

Tinea capitis: 4 weeks.

Onychomycosis:

  • Fingernail onychomycosis: 6 weeks.
  • Toenail onychomycosis: 12 weeks.

Lamifen cream: can be applied once or twice daily.

  • It is important to clean and thoroughly dry the affected areas before applying Lamifen cream.
  • Apply Lamifen cream to the affected skin and surrounding area in a thin layer and rub in lightly.
  • If you need to apply Lamifen cream between (toes, fingers, buttocks, sub-mammary or in the groin region), the application may be covered with gauze especially at bed time.

Recommended duration of treatment by cream

  • Tinea corporis/ cruris, cutaeneous candidiasis: 1-2 weeks.
  • Tinea versicolor: 2 weeks.
  • Tinea pedis (athlete’s foot): 1 week.

Composition

  • Lamifen tablet:125 mg terbinafine base.
  • Lamifen cream: 1% terbinafine as hydrochloride (10mg/1g of cream).
  • Lamifen tablet: 250 mg terbinafine base.

Pharmacodynamic properties

Lamifen tablet: Terbinafine hydrochloride is a synthetic allylamine which has a broad spectrum of activity against fungal pathogens of the skin, hair and nails including Dermatophytes, Microsporum, Epidermophyton floccosum, Yeasts and Pityrosporum.

Terbinafine hydrochloride: is fungicidal or fungistatic against yeasts depending on the species. Terbinafine hydrochloride: acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergostero an essential component of fungal cell membrane. This leads to a deficiency in ergosterol and to accumulation of squalene resulting in fungal cell death.

When given orally, the drug concentrates in the skin, hair and nails at levels associated with fungicidal activity. When given topically, the drug has rapid onset of action & can be effective with short treatment duration.

Adverse effects

Lamifen tablet

In general Lamifen tablet is well tolerated. Side effects are transient & mild.

  • Common: Diarrhea, nausea, feeling of fullness.
  • Uncommon: Taste disturbance (recover after stopping the drug), mild abdominal pain, rash.
  • Very rare: Allergic skin reactions (itching, peeling, redness, urticaria), malaise, fatigue, arthralgia, myalgia,

Lamifen – Patient Information Leaflet