Itranox Capsules – Broad Spectrum Antifungal

Composition

Each capsule contain: Itraconazole 100 mg.

Properties

• Itraconazole is active against infections with dermatophyts, yeast, candida, Aspergillus, cladosporium, other yeast & fungi.
• The bioavailability is maximal when the capsules are taken immediately after a full meal.

Indications

• Gynecological indications: vulvovaginal candidacies.
• Dermatological / ophthalmological indications: Pityriasis versicolor, dermatomycosis, fungal Keratitis and oral candidacies.

Dosage for Gynecological indications

Vulvovaginal candidacies: recommended dose 200mg twice daily for 1 day, or 200mg once daily for 3 days.

Dosage for Dermatological indications

• Pityriasis versicolor dose: 200mg once daily for 7 days.
• Dermatomycosis dose: 100mg once daily for 15 days.
• Fungal Keratitis dose: 200mg once daily for 21 days
• Oral candidacies dose: 100mg once daily for 15 days
• Tinea pedis & palmer tinea manus dose: 100mg once daily for 15 days

Contra-Indications

• Patients with liver & renal impairment should monitor the Itraconazole plasma concentration & should adapt the dose.
• Not to be given for hypersensitive patients, pregnant & lactating women.

Interactions

• Terfenadine, Astemizole.
• Enzymes – inducing drugs such as phenytoin, rifampicin reduce the oral bioavailability.
• Oral anticoagulants, digoxin, cyclosporin, calcium channel blockers and quinidine, their dose are to be reduced when taken with itraconazole.

Side Effects

The most common are: Dyspepsia, nausea, abdominal pain & constipation.

Packing

• Box contains 1 strip of 4 capsules.
• Box contains 3 strip of 4 capsules each.

Itranox Capsules  is a product of Adwia Pharmaceuticals , Egypt – ATC Code: J02AC02