Fungican® [fluconazole] – Broad Spectrum Antifungal

Composition

Each capsule contains fluconazole 150 mg.

Properties

Fluconazole is a triazole antifungal drug which in sensitive fungi inhibits cytochrome P-450 dependent enzymes resulting in impairment of ergosterol synthesis in fungal cell membranes.

It is active against a broad spectrum of yeasts and other fungal pathogens including: Blastomyces dermatitidis, Candida spp., Coccidioides immitis, Cryptococcus neoformans, Epidermophyton reduce the clearance of theophylline.

The efficacy of oral contraceptives may be reduced.

Dosage and Administration

1- Vaginal candidiasis

For Vaginal candidiasis: One capsule (150 mg) as a single dose. To reduce the incidence of recurrent vaginal candidiasis, one capsule (150 mg) once monthly dose may be used. The duration of therapy should be individualized, but ranges from 4-12 months.

2-Dermal infections

For dermal infections including tinea pedis, corporis, cruris and candida infections, the recommended dose is one capsule (150 mg) once weekly. Duration of treatment 2-4 weeks, tinea pedis may require up to 6 weeks.

Tinea versicolor: 2 capsules (300 mg) once weekly for 2-3 weeks.

Onychomycosis: One capsule (150 mg) once weekly for 3-6 months (fingernails) and 6-12 months (toenails).

3-Oropharyngeal and esophageal candidiasis

For Oropharyngeal and esophageal candidiasis: One capsule (150 mg) daily for 7-14 days (except in severely immunocompromised patients); for 14 days in atrophic oral candidiasis associated with dentures; for 14-30 days in other mucosal infections: esophagitis, non-invasive bronchopulmonary infections.

4-Systemic candidiasis

For Systemic candidiasis, cryptococcal meningitis and other cryptococcal infections : Treated with an initial dose of 2-3 capsules (300-450 mg) on the first day, followed by 1-2 capsules (150-300 mg) daily.

Duration of therapy is based on clinical and mycological response, but is usually at least 6-8 weeks in cryptococcal meningitis.

Fluconazole may also be used in daily doses of 100-200 mg to prevent relapse following a primary course of treatment for acute cryptococcal meningitis in patients with AIDS.

5-Immunocompromised patients

In immunocompromised patients at risk of fungal infections, fluconazole may be given prophylactically in a dose of 50-400 mg daily.

6-patients with renal impairment

In patients with renal impairment Since fluconazole is primarily excreted by the kidneys, fluconazole dosage must be adjusted for renal impairment according to creatinine clearance. Initial loading dose of 50-400 mg should be given on the first day of treatment, after the loading dose, the daily dose (according to indications) should be based on the following table:

Creatinine clearance (ml/min)	Percent of recommended dose
>50	100%
11-50	50%
regular dialysis	100% after each diaylsis

No dosage adjustment is needed in patients with renal impairment given single-dose therapy.

How Supplied

Fungican® capsules: Pack of one capsule containing 150 mg fluconazole.

Keep all medicaments out of reach of children

Product of: AMOUN PHARMACEUTICAL CO. El-Obour City, Cairo, Egypt. ATC Code: J02AC01