Etaphylline phenobarbital suppository is a powerful treatment option used for managing chronic respiratory diseases. This medication combines the bronchodilating effects of Acefylline piperazine and the sedative properties of Phenobarbital. Patients suffering from long-term respiratory conditions, such as asthma or chronic bronchitis, may benefit from this product due to its ability to ease breathing and provide calming effects. Understanding its purpose, ingredients, and precautions is essential for safe and effective use.
Active Ingredients
Acefylline Piperazine (500 mg)
Acefylline piperazine is a derivative of theophylline. It works primarily as a bronchodilator [a medication that helps widen the airways in the lungs, making breathing easier]. This makes it highly effective for patients with respiratory conditions, as it relaxes the muscles in the airways, improving airflow to the lungs.
Phenobarbital (100 mg)
Phenobarbital is a sedative [a drug that induces calm or sleep]. It is commonly used to help control anxiety and nervousness. In the Etaphylline phenobarbital suppository, its role is to calm the central nervous system, which can help alleviate some of the discomfort caused by chronic respiratory issues, including breathlessness and panic associated with shortness of breath.

Indications for Use
Etaphylline phenobarbital suppository is indicated for treating chronic respiratory diseases [long-lasting conditions affecting the lungs and airways, such as chronic bronchitis or asthma]. Its dual action makes it suitable for conditions where a combination of bronchodilation and sedation is needed.
Conditions Treated:
- Chronic bronchitis
- Asthma
- Emphysema
- Other chronic obstructive pulmonary diseases (COPD)
Benefits:
- Improves airflow: The bronchodilator action of Acefylline piperazine helps patients breathe more easily by expanding the airways.
- Calms symptoms: Phenobarbital provides a sedative effect, reducing anxiety and calming the respiratory system, making it easier to manage chronic conditions.
- Convenient administration: In suppository form, it’s suitable for patients who have difficulty swallowing oral medications.
Dosage and Duration of Use
Recommended Dosage:
The usual recommended dosage is one suppository as prescribed by a healthcare professional. However, the dosage may be adjusted depending on the patient’s age, weight, and the severity of the respiratory condition.
Duration:
This medication should be used as long as prescribed by the physician. It’s important to follow the recommended duration and consult with the doctor if symptoms persist or worsen.
Warnings and Precautions
Side Effects:
Some patients may experience side effects, including:
- Nausea [feeling of sickness with an inclination to vomit]
- Vomiting
- Insomnia [difficulty falling or staying asleep]
- Headache
- Palpitations [an abnormal awareness of the heartbeat, often rapid or irregular]
- Sedation [a state of calm or sleepiness]
- Confusion and fatigue [excessive tiredness]
- Vertigo [a sensation of spinning dizziness]
Precautions:
- Elderly patients: Use caution in older adults, as they may be more susceptible to the sedative effects of phenobarbital, which can lead to increased risk of falls or respiratory depression.
- Cardiac and liver disease: Patients with heart or liver conditions should use Etaphylline phenobarbital suppository cautiously, as it can impact these systems.
- Respiratory insufficiency: Phenobarbital’s respiratory depressant effect [a slowing or weakening of the breathing process] can worsen symptoms in patients with severe breathing difficulties.
Drug Interactions:
- Avoid using with other xanthine medications: Xanthines like theophylline are similar to acefylline and could increase the risk of side effects.
- CNS depressants: Combining this medication with central nervous system (CNS) depressants, such as sleeping pills, tranquilizers, or alcohol, can enhance the sedative effects of phenobarbital.
Special Populations:
- Pregnancy & Lactation: Etaphylline phenobarbital suppository is not recommended for use during pregnancy or breastfeeding, as it may affect the baby’s development.
- Children: Always consult a doctor before administering this medication to children, as their response to sedatives may differ from adults.
Price and Product Information
Pricing:
Etaphylline phenobarbital suppository is available in Egypt at an affordable price of 8 L.E. per suppository.
Packaging and Availability:
The product is packaged as individual suppositories and is widely available in pharmacies across Egypt. Patients can ask their healthcare provider or pharmacist about its availability.
Conclusion
Etaphylline phenobarbital suppository offers an effective solution for managing chronic respiratory conditions. Its dual action as a bronchodilator and sedative helps patients breathe easier and reduces anxiety related to breathlessness. However, careful adherence to dosage and monitoring for side effects are crucial to ensure safe and effective use.
For patients dealing with long-term respiratory conditions, this medication may provide much-needed relief, but consulting a healthcare professional before use is essential.
Etaphylline phenobarbital suppository is produced by Memphis Pharmaceutical Industries, an Egyptian company that distributes and exports its products to various countries in Africa and the Middle East.
Dr. Ahmad Baker, PharmD
Senior Pharmacist & Health Educator
With over 23 years of clinical experience in hospital and community pharmacy across Egypt and Saudi Arabia, Dr. Ahmad specializes in reproductive health and pharmaceutical safety. He is dedicated to providing evidence-based guidance to empower patients in the MENA region.
Medical Disclaimer: This content is for educational purposes and reflects the latest pharmaceutical protocols. It is not a substitute for personal medical advice. Always consult Dr. Ahmad Baker or your healthcare provider before starting any treatment.

