DOLO-D® PLUS Tablet indications
- Relief of all symptoms accompanying upper respiratory tract allergy.
- Hay fever.
- Sinusitis.
- Common cold symptoms such as: headache, bone aches, fever, sneezing, watery eyes & upper respiratory tract congestion
Dosage & Administration
The daily recommended dose is 1-2 Tablets, three times per day, depending on the severity of the case. Dosage should not exceed 6 Tablets per day.
Contraindications
DOLO-D® PLUS is contraindicated in:
- Patients receiving antihypertensives or antidepressants.
- Patients with heart diseases.
- Patients with diabetes.
- Patients with prostatic enlargement or thyroid diseases.
- Patients with closed angle glaucoma.
- Children <6 years.
- pregnant women
DOLO-D® PLUS Tablets – Side Effects
May Cause Steven-Johnson Syndrome, Abdominal Pain with Cramps, Dizziness, Heartburn, Nausea, Skin Rash, Insomnia, Nervousness, drowsiness, Thick bronchial Secretions, Excitement, Gastrointestinal Irritation, Diarrhea, Vomiting, GIT ulceration and bleeding, hypertension, rapid heart beat and palpitation.
Drug Interactions
- Narcotic drugs as: Chloroform, cyclopropane, infloran, Haluthane, Isoflorane, Methoxyflorane
- Possible diminution of effect of antihypertensive drugs.
- Beta-adrenergic blocking agents.
- Sympathomimetics.
- CNS stimulants.
- Citrate.
- Digitalis glycoside.
- Nitrates.
- Antidepressant e.g MAOIS concurrently or after 2 weeks of stopping.
Pregnancy & Lactation
It is recommended not to use DOLO-D® PLUS Tablets in the first trimester of pregnancy, except under medical supervision.
Composition
Each Tablet contains: Active Ingredients:
- 200 mg Ibuprofen
- 30 mg Pseudoephedrine hydrochloride
- 2 mg Chlorpheniramine maleate
Inactive Ingredients: Lactose monohydrate, Starch, Talc powder, Magnesium Stearate.
Pharmaceutical form
Oral Tablets
Pharmacological action
DOLO-D® PLUS is well balanced formula consists of:
1- Ibuprofen
Ibuprofen is Analgesic, antipyretic, anti inflammatory, it is an NSAIDs which is believed to work through inhibition of cyclooxygenase enzyme (COX) thus inhibiting prostaglandin synthesis.
- Approximately 80% of an oral dose of ibuprofen is absorbed from the GI tract, Absorption rate is slower and plasma concentrations are reduced.
- Ibuprofen is metabolized via oxidation.
- Excretion of ibuprofen is essentially complete within 24 hours following oral administration. About 50-60% of an oral dose is excreted in urine as metabolites within 24 hours. Less than 10% of the drug is excreted in urine unchanged; the remainder of the drug is eliminated in feces.
2- Pseudoephedrine hydrochloride
Potant vasoconstrictor equal to ephedrine with mild side effects. Pseudoephedrine is a sympathomimetic amine-that, its principal mechanism of action relies on its indirect action on the adrenergic receptor system. When the adrenergic receptor activated by pseudoephedrine, the muscles contract, causing the blood vessels to constrict (vasoconstriction). The vasoconstriction that pseudoephedrine produces is believed to be principally an adrenergic receptor response. Pseudoephedrine to some extent, has decongestant action, pseudoephedrine shows greater selectivity for the nasal mucosa and a lower affinity for central nervous system (CNS) adrenergic receptors than other sympathomimetic amines.
- Pseudoephedrine hydrochloride is completely absorbed from the GI tract.
- pseudoephedrine is presumed to cross the placenta and to enter CSF.
- Pseudoephedrine distributes into breast milk; about 0.5% of an oral dose isdistributed into breast milk over 24 hours.
- Pseudoephedrine is incompletely metabolized (less than 1%) in the liver by N demethylation to an inactive metabolite ,
- The drug and its metabolite are excreted in urine; 55-96% of a dose is excreted unchanged.
3- Chlorpheniramine maleate
Chlorpheniramine maleate is Antihistamine agent of short duration of action with mild sedative effect
- Chlorpheniramine maleate: Appears to be well absorbed following oral administration; however, the drug undergoes substantial metabolism in the GI mucosa during absorption and on first pass through the liver.
- Chlorpheniramine and its metabolites are apparently excreted almost completely in urine.
Precautions & Warning
Cardiovascular Risk: NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. NSAIDS are contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
DOLO-D® PLUS: A Trusted Product by BORG PHARMACEUTICAL INDUSTRIES
DOLO-D® PLUS is proudly manufactured by BORG PHARMACEUTICAL INDUSTRIES, an Egyptian shareholding company, was established in 2001 for manufacturing pharmaceuticals, cosmetics, and dietary supplements. Founded by Egyptian pharmacists, health professionals, and businessmen, it started production in July 2004. The company’s capital increased over the years, reaching 100 million L.E. in 2017. It obtained various ISO certifications for its management system. Authorized manufacturing activities include solid, liquid, and semi-solid dosage forms.
To obtain further information, please reach out to Borg Pharmaceutical Industries. Borg Pharmaceutical Industries has multiple locations in Egypt:
- Factory Address: District 17, Areas 1, 3, Industrial Zones 3, Borg El Arab New City, Alexandria. Tel: (+203) 4622151/2/3/4, (+2) 012/27872244 Fax: (203) 4622155
- Alexandria Scientific Office: Address: Alex Agricultural Road, Pharma City Smouha, Pancee Building, 2nd Floor, Alexandria. Tel: (+2) 012/27865773, (+2) 012/81367423
- Cairo Branch: Address: Refaat Hassan Street, Area 7/4/1 First Floor, Apartment No. “1”, Beside Diar City Compound, El Haddaba El Wossta, Second District, Mokattam, Cairo. Tel: (+202) 27303131, (+2) 27303132, (+2) 27303133 Fax: (+202) 27303130
- Mansoura Branch: Address: 14, Ali Ibn Abi Taleb Street, Samia EL Gaml Division, branched from Ahmed Maher St. Tel: (+2050) 2225847 Fax: (+2050) 2225847
- Upper Egypt Souhag Branch: Address: 136, Eltahrir Street, Beside Police Station. Tel: (+2093) 2109300
Dr. Ahmad Baker, PharmD
Senior Pharmacist & Health Educator
With over 23 years of clinical experience in hospital and community pharmacy across Egypt and Saudi Arabia, Dr. Ahmad specializes in reproductive health and pharmaceutical safety. He is dedicated to providing evidence-based guidance to empower patients in the MENA region.
Medical Disclaimer: This content is for educational purposes and reflects the latest pharmaceutical protocols. It is not a substitute for personal medical advice. Always consult Dr. Ahmad Baker or your healthcare provider before starting any treatment.