Clexane Injections

Clexane is available as pre-filled syringes for subcutaneous injection. It contains the active ingredient enoxaparin sodium. It is used to treat and prevent blood clots. It should only be used under medical supervision based on the medical condition.

What are the components of Clexane injections?

  • Enoxaparin sodium is a blood-thinning medication that prevents the body’s natural clotting factors from making the blood too likely to form dangerous clots.
  • It works in two ways:
    • Stopping existing clots from getting bigger, which helps the body break them down and prevents complications.
    • Preventing new blood clots from forming in the blood, reducing the risk of developing them.

What are the types of Clexane injections?

  • Clexane 20mg (Clexane 2000 IU) – Pre-filled syringes containing 20mg of the active ingredient per 0.2mL, equivalent to 2000 international units.
  • Clexane 40mg (Clexane 4000 IU) – Pre-filled syringes containing 40mg of the active ingredient per 0.4mL, equivalent to 4000 international units.
  • Clexane 60mg (Clexane 6000 IU) – Pre-filled syringes containing 60mg of the active ingredient per 0.6mL, equivalent to 6000 international units.
  • Clexane 80mg (Clexane 8000 IU) – Pre-filled syringes containing 80mg of the active ingredient per 0.8mL, equivalent to 8000 international units.

What is Clexane used for?

This medication is used to treat existing blood clots in the body. It is also used to prevent blood clots in situations like:

  • Unstable angina (where blood flow to the heart is reduced)
  • After surgery
  • During long periods of bed rest due to illness
  • Kidney disease patients undergoing dialysis

Clexane is used to treat blood clots as it prevents undesirable blood clotting and stops existing clots from increasing in size, allowing the body to break them down more easily.

Clexane may also be prescribed after IVF procedures in some cases to reduce miscarriage risk from blood clots.

What is the Clexane injection dose?

The dose is determined by the doctor based on the medical condition. The dose may be reduced in kidney impairment. Typical doses are:

  • To treat blood clots: The usual treatment dose is 1.5mg per kg of body weight daily, injected under the skin for at least 5 days.
  • To prevent clots after heart attacks or surgery: Typical doses are 20-40mg daily depending on clotting risk.
  • For bedridden patients: Usually 40mg daily for 6-14 days.
  • For dialysis patients: Usually 1mg per kg of body weight.

How to use Clexane injections

  • Wash hands and injection site
  • Relax in comfortable position
  • Choose an area of the abdomen, 5cm away from belly button
  • Clean and disinfect skin
  • Pinch skin before inserting needle vertically at 90 degree angle
  • Press plunger to deliver full dose
  • Withdraw needle fully before releasing pinched skin

Potential Side Effects

Common side effects include injection site reactions like skin discoloration, pain, bruising or bleeding. Less common side effects include severe headaches, abdominal pain, allergic reactions, liver enzyme changes, and potassium level changes.

Contraindications

Clexane should not be used in case of:

  • Hypersensitivity to heparin or any of the medication components
  • Increased tendency for bruising or bleeding
  • Stomach or intestinal ulcers
  • Bleeding strokes
  • Heart infections
  • Jaundice or liver problems
  • Eye blood vessel disorders

It should not be used in children.

Alternative Medications

  • Similar medications containing the same active ingredient:
    • Cutenox
    • Lowparin
    • Lovenox
  • Alternative anticoagulants with different active ingredients:
    • Innohep
    • Arixtra
    • Cal Heparine

Drug Interactions

Inform your doctor about any medications you are taking before using Clexane to avoid harmful interactions, especially:

  • Warfarin
  • Aspirin
  • Anti-inflammatories
  • Steroids
  • Diuretics

Difference from Heparin

While Clexane contains enoxaparin, heparin is another anticoagulant medication. The key differences are:

  • Heparin: Given by IV infusion in hospital, requires blood monitoring, higher side effects risk.
  • Enoxaparin: Lasts longer so can be injected under skin without monitoring. Lower side effects risk. Self-injectable.

Difference from Warfarin

Warfarin is an oral anticoagulant tablet, while enoxaparin is only available as subcutaneous injections.

Does Clexane cause bleeding?

Yes, this medication can increase bleeding risk, especially if the patient has an inherited bleeding disorder or condition causing excessive bleeding.

Does Clexane affect liver enzymes?

Yes, using Clexane may temporarily impact liver enzymes, but this effect typically resolves after stopping the medication.

Does Clexane cause headaches?

Clexane may cause headaches, but severe or persistent headaches should be medically evaluated to rule out serious issues.

What are the benefits of Clexane injections in early pregnancy?

Clexane injections in early pregnancy help prevent dangerous blood clots that can form more easily during pregnancy. They also reduce miscarriage risk, especially in women prone to clot-related pregnancy loss. Treatment may start early and continue based on the patient’s condition.

What are the benefits in late pregnancy?

Clexane is used to prevent pregnancy-related blood clots, but should be stopped 24 hours before delivery or once labor contractions have begun.

What are the benefits for the fetus?

By preventing maternal blood clots and miscarriage, Clexane promotes safe delivery and protects fetal life in at-risk mothers.

Is Clexane available as a syrup?

No, Clexane is only available as pre-filled subcutaneous injection syringes, not as tablets, capsules, syrups or any other oral formulations.

How should Clexane injections be stored?

Store at room temperature below 25°C in original packaging protected from light. Do not freeze.