An Overview of Zacco, an Anti-Anxiety and Seizure Medication

Zacco is a prescription medication used to treat severe anxiety in adults and seizures (epilepsy) in adults and children over 2 years old. It contains the active ingredient clobazam and belongs to a class of medications called benzodiazepines.

Benzodiazepines work by enhancing the effects of a brain chemical called GABA, resulting in a calming effect. Specifically, Zacco has the following approved uses:

  • Short-term treatment of severe anxiety symptoms in adults
  • Treatment of epileptic seizures in adults and children over 2 years, used together with other seizure medications
  • Short-term treatment of symptoms like agitation in patients with schizophrenia or other psychotic illnesses, used with other medications

How Zacco Is Taken

  • Zacco comes as an oral suspension liquid that is taken by mouth
  • The dose prescribed depends on the condition being treated
  • Doses may be adjusted over time based on response
  • It is usually taken for 2-4 weeks for anxiety; treatment may be longer term for seizures

Before Taking Zacco

Before starting Zacco, tell your doctor about any medical issues you have and medications you are taking. Specific things to discuss:

  • Allergies to clobazam or other medications
  • Use of opioids, sedatives, or certain other drugs that interact with Zacco
  • Liver or kidney disease
  • Respiratory or breathing problems
  • History of depression, psychosis, suicidal thoughts
  • Pregnancy, breastfeeding or plans to become pregnant

While Taking Zacco

  • Take Zacco exactly as prescribed by your doctor
  • Do not suddenly stop taking it unless directed by your doctor
  • Avoid alcohol while taking Zacco
  • Use caution with driving and operating machinery until you understand the effects

Potential Side Effects

Common potential side effects of Zacco include:

  • Drowsiness
  • Dizziness
  • Trouble concentrating
  • Headache
  • Nausea

More serious side effects are possible. Seek medical care if you experience:

  • Rash
  • Breathing problems
  • Withdrawal symptoms when stopping the medication
  • Thoughts of self-harm


  • Zacco has the potential to be habit-forming with long-term use
  • Sudden discontinuation may cause withdrawal symptoms
  • Paradoxical reactions like irritability and aggression are possible

Frequently Asked Questions About Zacco

Here are answers to some common questions about this anti-anxiety and seizure medication.

What is Zacco used for?

Zacco is approved to treat severe short-term anxiety in adults and epilepsy in adults and children over 2. It can provide rapid relief of anxiety symptoms and help control seizures when used properly.

How does Zacco work?

Zacco contains clobazam, a benzodiazepine drug that enhances activity of the brain chemical GABA. This produces a calming effect that relieves anxiety and prevents seizures.

What are the side effects of Zacco?

Common side effects include drowsiness, dizziness, trouble concentrating, headache, and nausea. More serious side effects like breathing problems and rash are possible. Paradoxical reactions like aggression may also occur.

Is Zacco addictive?

Yes, Zacco does carry a risk of physical and psychological dependence with long-term use. It should only be taken short-term unless epilepsy warrants extended treatment. Do not stop Zacco suddenly without medical supervision.

Can I drink alcohol while taking Zacco?

No, avoid drinking alcohol while taking Zacco because it increases side effects like extreme drowsiness. The combination can be very dangerous.

How long does Zacco take to work?

Zacco starts working relatively quickly compared to other anxiety medications. Anti-anxiety effects may be felt within 1-2 hours; maximum benefits for anxiety take 1-2 weeks. Seizure control happens rapidly as well.

Can I take Zacco while pregnant or breastfeeding?

Zacco has not been proven safe for pregnancy or breastfeeding. Infants may experience sedation, low muscle tone, breathing issues and withdrawal symptoms if exposed. Discuss with your doctor.

Who should not take Zacco?

You should not use Zacco if you:

  • Are allergic to clobazam or benzodiazepines
  • Have severe liver issues, breathing problems or myasthenia gravis
  • Have untreated depression or suicidal thoughts

Does Zacco cause memory loss?

Yes, short-term memory loss and confusion are potential temporary side effects while taking Zacco. Paradoxical reactions may also cause disordered thinking. Memory typically improves once the medication is stopped.

What should I avoid while using Zacco?

Avoid alcohol and activities requiring mental alertness like driving while taking Zacco until you understand how it affects you. Sedatives, opioids and certain other drugs also interact with Zacco.

Can you overdose on Zacco?

Yes, Zacco overdose is possible, especially when combining Zacco with alcohol, opioids, or other central nervous system depressants. Seek emergency care for an overdose. Bring the medication with you to help doctors.

How do I stop taking Zacco?

Never stop Zacco suddenly without talking to your doctor first. Suddenly stopping can lead to dangerous withdrawal symptoms. Your doctor will have you gradually lower the dosage over time to safely discontinue it.

What should I do if I miss a dose?

If you miss a dose of Zacco, take it as soon as you remember. However if it is close to the time for your next scheduled dose, skip the missed dose altogether to avoid taking too much medication. Do not double your dose.

Talk to your doctor if you have any other questions related to safely and effectively using Zacco! Proper use of this medication under medical supervision can help provide rapid relief of severe anxiety or seizure episodes. But misuse does pose serious risks.

As always, consult your doctor with any specific questions related to taking Zacco or managing your medical condition. Report any serious side effects promptly as well. Use this medication only as prescribed and directed.

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