Zakan Skin Cream Topical Antifungal

Zakan cream is indicated for the topical treatment of:

  • Tinea pedis (Athlete’s foot), tinea corporis, tinea cruris that is caused by Trichophyton rubrum, T. mentagrophytes & Epidermophyton floccosum.
  • Tinea versicolor (pityriasis), which is caused by Malassezia furfur.
  • Cutaneous candidiasis caused by candida species.
  • Seborrheic dermatitis caused by Malassezia ovale (p. ovale).

Dosage and Administration

For Cutaneous candidiasis, tinea corporis, tinea cruris, tinea pedis or pityriasis versicolor:

  • Zakan cream to be applied once a day to the affected and surrounded skin area once daily for 2 weeks in order to reduce the possibility of recurrence.
  • Patients with tinea versicolor usually require 3 weeks of treatment.
  • Patients with tinea pedis require 6 weeks of treatment.

For seborrheic dermatitis: Zakan cream to be applied twice a day to the affected and surrounding skin area for 4 weeks or until clinical cure.


Each 100 gm contains: Ketoconazole 2 gm.

Mode of Action and Microbiology

Zakan is a broad-spectrum synthetic antifungal cream used for topical treatment of skin and mucous membrane fungal infections. The antifungal properties of Zakan cream is related to its ability to impair the synthesis of ergosterol, which is a vital compound of fungal and yeast cell membranes required for growth and functions of these organisms.

Ketoconazole inhibits the in vitro growth of the following dermatophytes and yeasts:

  • Dermatophytes: Trichophyton rubrum, T. mentagrophytes, T. tonsurans, Microsporum canis, M. audouini, M. gypseum and Epidemophyton floccosum.
  • Yeasts: Candida albicans, C.tropicalis, Malassezia ovale, Malassezia fufur.


Zakan cream is contraindicated in patients who have shown hypersensitivity to Ketoconazole or the excipients of this formulation.


Zakan cream is not for ophthalmic use.


General: If a reaction suggesting sensitivity or chemical irritation occurs, use of the medication should be discontinued.


Zakan cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers

It is not known whether Zakan cream administered topically could result in sufficient systemic absorption to produce detectable quantities in breast milk or not.

Nevertheless, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Pediatric Use: Safety and effectiveness in children have not been established.


A tube of 15 gm

زاكان كريم للجلد مضاد للفطريات
زاكان كريم للجلد مضاد للفطريات

Zakan patient information leaflet