Your Guide to Axaban-Denk: Keeping Blood Clots at Bay

Are you considering taking Axaban-Denk 5 mg for your health? Understanding your medication is paramount. In this article, we will provide you with essential information about Axaban-Denk, including its purpose, usage, precautions, potential side effects, and storage guidelines. Whether you are a patient, caregiver, or simply curious, this article will help you grasp the key facts about Axaban-Denk.

What Is Axaban-Denk and What Is It Used For?

Axaban-Denk contains the active ingredient apixaban and is classified as an antithrombotic agent. It plays a vital role in preventing the formation of blood clots by inhibiting Factor Xa, an important component in the process of blood clotting. This medication is used in adults for the following conditions:

  1. Preventing Blood Clots in Patients with Atrial Fibrillation: Patients with irregular heartbeats (atrial fibrillation) and at least one additional risk factor may develop blood clots in the heart. These clots can travel to vital organs, causing strokes or systemic embolism. Axaban-Denk helps prevent such blood clots that can be life-threatening.
  2. Treating Deep Vein Thrombosis and Pulmonary Embolism: Axaban-Denk is used for treating blood clots in the veins of the legs (deep vein thrombosis) and blood vessels of the lungs (pulmonary embolism). It also helps in preventing the recurrence of blood clots in these areas.

What You Need to Know Before Taking Axaban-Denk

Before commencing your Axaban-Denk treatment, consider these crucial factors:

Do Not Take Axaban-Denk If:

  • You are allergic to apixaban or any other ingredients listed in section 6 of the package leaflet.
  • You are experiencing excessive bleeding.
  • You have a medical condition that increases the risk of severe bleeding, such as a recent ulcer in your stomach or bowel, or bleeding in your brain.
  • You have a liver disease that heightens the risk of bleeding (hepatic coagulopathy).
  • You are taking medications to prevent blood clotting (e.g., warfarin, rivaroxaban, dabigatran, or heparin) unless it’s part of a planned anticoagulant treatment change or you are receiving heparin via a venous or arterial line to maintain its patency.

Warnings and Precautions

Before using Axaban-Denk, consult your healthcare provider if you have any of the following:

  • An increased risk of bleeding, which may arise from bleeding disorders, very high uncontrolled blood pressure, being older than 75, or weighing 60 kg or less.
  • Severe kidney disease or if you are on dialysis.
  • Liver issues or a history of liver problems.
  • A prosthetic heart valve.
  • An unstable blood pressure or a planned surgical procedure to remove blood clots from your lungs.
  • Knowledge of having antiphospholipid syndrome, a disorder that increases blood clot risk.

If you are to undergo surgery or any procedure that may lead to bleeding, your doctor might advise temporarily stopping Axaban-Denk. Always consult your doctor if you’re uncertain about a procedure’s impact on your medication.

A Note on Children and Adolescents

Apixaban is not recommended for children and adolescents under 18 years of age.

Axaban-Denk and Other Medications

Inform your doctor or pharmacist about any other medications you are taking or have recently taken. Some medicines can enhance or reduce the effects of apixaban, which may necessitate adjustments in your treatment plan. Discuss these potential interactions with your healthcare provider.

Pregnancy and Breastfeeding

If you are pregnant, breastfeeding, planning to become pregnant, or unsure about your fertility, consult your healthcare provider before taking Axaban-Denk. The effects of apixaban during pregnancy and on the unborn child are not yet fully understood. Breastfeeding while taking Axaban-Denk is also a matter to be discussed with your doctor.

Driving and Using Machinery

Apixaban does not impair your ability to drive or operate machinery.

Axaban-Denk Contains Lactose

If your doctor has informed you that you have an intolerance to certain sugars, consult with your doctor before taking this medication.

Sodium Content in Axaban-Denk

Each film-coated tablet of Axaban-Denk contains a minimal amount of sodium, which is considered “sodium-free.”

How to Take Axaban-Denk

Taking your medication as prescribed is crucial for its effectiveness. Here’s how to take Axaban-Denk:

  • Swallow the tablet whole with a glass of water. It can be taken with or without food.
  • Aim to take the tablets at the same times each day to optimize its therapeutic effect.
  • If you have difficulty swallowing the tablet, consult your doctor about alternative administration methods, such as crushing the tablet and mixing it with water, dextrose, apple juice, or apple puree just before consumption.


  1. Preventing Heart Clots: The recommended dose is one tablet of Axaban-Denk 5 mg twice a day. However, your doctor may adjust the dose to one tablet of Axaban-Denk 2.5 mg twice a day based on your specific condition and risk factors.
  2. Treating Leg and Lung Clots: For the first 7 days, take two tablets of Axaban-Denk 5 mg twice a day, and then continue with one tablet of Axaban-Denk 5 mg twice a day. After completing six months of treatment, your doctor may recommend one tablet of Axaban-Denk 2.5 mg twice a day to prevent clot recurrence.

If you’ve been advised to change your anticoagulant treatment, consult your doctor for proper transitioning, whether from Axaban-Denk to another anticoagulant, or vice versa.

If you take more Axaban-Denk than prescribed or forget a dose, contact your doctor. Do not discontinue Axaban-Denk without your doctor’s guidance, as stopping the medication prematurely could elevate the risk of blood clots.

Possible Side Effects

As with any medication, Axaban-Denk may lead to side effects, though not everyone experiences them. Here are some common side effects:

General Side Effects:

  • Bleeding, which can be severe and necessitate immediate medical attention.

Preventing Heart Clots:

  • Common side effects may include bleeding, anemia, low blood pressure, nausea, and increased gamma-glutamyltransferase (GGT).

Treating Leg and Lung Clots:

  • Common side effects may include bleeding, anemia, reduced platelet count, nausea, and increased GGT or alanine aminotransferase (ALT).

The side effects listed here are not exhaustive. There may be uncommon or rare side effects as well. If you experience any side effects while taking Axaban-Denk, promptly contact your healthcare provider.

How to Store Axaban-Denk

To ensure the efficacy and safety of your medication, follow these storage guidelines:

  • Keep Axaban-Denk out of reach of children.
  • Do not use Axaban-Denk after the expiry date indicated on the carton and bottle.
  • Store Axaban-Denk below 25°C (77°F).
  • Dispose of unused medications properly, and consult your pharmacist for guidance.

This article serves as a general guide and should not substitute for professional medical advice. If you have any questions or concerns about Axaban-Denk or your specific health condition, consult your healthcare provider or pharmacist for personalized guidance. Your health and well-being are of utmost importance, so trust your healthcare professional to make the best decisions for you.

Contents of the Pack and Additional Information

What Axaban-Denk 5 mg Contains

  • Active substance: Apixaban (5 mg per film-coated tablet)
  • Other ingredients: Lactose, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, magnesium stearate, hypromellose, titanium dioxide, triacetin, iron oxide red.

General Classification for Supply

Axaban-Denk 5 mg is a medicinal product subject to medical prescription.

Appearance and Packaging

  • Axaban-Denk 5 mg tablets are pink, oval-shaped, biconvex film-coated tablets.
  • Available in HDPE bottles containing 60 film-coated tablets.

Marketing Authorization Holder

  • Prinzregentenstr. 79
  • 81675 München, Germany

Manufacturer Information

  • Manufacturer of bulk, packaging, and batch release: Combino Pharm Malta Ltd, HF-60 Hal Far Industrial Estate, Hal Far BBG 3000, Malta

This article was last revised in May 2019.

Patient Alert Card

Inside your Axaban-Denk pack, you will find a Patient Alert Card. This card includes essential information and should be kept with you at all times. It includes:

  • Your name
  • Birthdate
  • Indication for use
  • Dose
  • Doctor’s name and phone number

Having this card helps your healthcare provider and other medical professionals understand your Axaban-Denk treatment.

Other Sources of Information

For additional information about Axaban-Denk, visit the Denk Pharma website at

Remember, your health and medication should always be discussed with your healthcare provider. If you encounter side effects or have questions about your treatment, don’t hesitate to reach out to your doctor or pharmacist for assistance. Your well-being is their priority.