Each 20 ml contains: Salbutamol sulphate 0.121 g.

Ventolin Respirator Solution is the mainstay of the symptomatic treatment of respiratory distress due to bronchospasm. Salbutamol, the active ingredient of Ventolin Respirator Solution, is a potent selective β2-adrenoreceptor agonist. It is the bronchodilator of first choice with a rapid maximal relaxation of bronchial smooth muscles for patients with asthma and other forms of reversible airway obstruction. It also has an antiallergic effect on mast cells causing inhibition of the release of bronchospasm mediators such as histamine, neutrophil chemo active factor and Prostaglandins.

Ventolin Respirator Solution, in nebulized form, is preferred in urgent cases of bronchospasm because the drug is delivered directly to the respiratory airways and is effective in smaller doses. Thus. it provides a more rapid relief of symptoms and causes fewer side effects than by other routes of administration. Salbutamol has the advantage of having longer duration of action than isoprenaline with a minimal effect on the heart.

• As a bronchodilator for the management of acute cases of bronchial asthma.
• For the treatment of severs reversible bronchospasm associated with bronchitis and emphysema.
• For management of status asthmaticus.

Although Salbutamol should be given with caution to patients with coronary insufficiency, sever hypertension, hyperthyroidism and diabetes mellitus, the nebulized form is safer in these conditions due to the resultant low plasma concentration. Salbutamol therapy is not recommended during the first three months of pregnancy unless strictly indicated.

Ventolin Respirator Solution is inhaled from any efficient nebulizing device to achieve rapidly effective bronchodilatation.

 A – Diluted solution: Ventolin Respirator Solution 0.5 -1.0 ml (2.5 – 5.0 mg of Salbutamol) should be dilated to a final volume of 2 to 4 ml with normal saline or water for injection.  The resulting solution is inhaled from a suitably driven nebulizer until aerosol generation ceases. This will take about 10 minutes, on using a correctly matched nebulizer and driving source.

B- undiluted solution: Ventolin Respirator Solution may be used undiluted for intermittent administration. In this respect, 2.0 ml of Ventolin Respirator Solution (10.0 mg of Salbutamol) is placed in the nebulizer and inhaled by the patient until bronchodilation is achieved. In severe cases, nebulization of the undiluted solution should be continued until aerosol generation ceases.

The same mode of intermittent administration is also applicable to children. The usual dosage for children up to the age of 12 years is 0.5 ml of Ventolin Respirator Solution (2.5 mg of Salbutamol) diluted to 2.0 to 4.0 ml with normal saline or water for injection. Severe cases may require the Use of higher doses of Salbutamol ( up to 5 mg ). N.B. The intermittent treatment may be repeated up to four times daily. or as prescribed by the physician.

For patients requiring assisted ventilation, administration of a diluted solution of Salbutamol is continued until adequate bronchodilatation is achieved. One ml of Ventolin Respirator Solution is diluted to 100 ml with normal saline giving a concentration of 50 mcg / ml of Salbutamol. The diluted solution is administered through a nebulizer coupled to an intermittent positive pressure ventilator, employing oxygen enriched air. Bronchodilatation occurs almost immediately and a maximal effect is achieved within 15 minutes from the start of therapy.

1. Ventolin Respirator Solution should not be used after a period of three months of opening the bottle.
2. Fresh dilutions should be prepared for each administration and any solution remaining in the nebulize/ after the relief of bronchospasm should be discarded.
3. To avoid contamination, the nebulizer should be thoroughly dewed according to the manufacturer’s instructions.

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