Understanding Ultracillin: Uses, Dosage, and Precautions

Ultracillin is a medication used to treat a variety of bacterial infections caused by susceptible microorganisms. In this comprehensive guide, we will explore the indications, positive impact, recommended dosage, common side effects, essential precautions, and practical tips for using Ultracillin.

Introduction to Ultracillin

Ultracillin is a combination medication containing two active ingredients: Sulbactam and Ampicillin. Sulbactam works as an irreversible inhibitor of beta-lactamases, enzymes produced by bacteria that render them resistant to penicillins. Ampicillin, on the other hand, is a bactericidal agent that inhibits the synthesis of bacterial cell walls, leading to the destruction of bacteria.

Indications for Use

Ultracillin is indicated for the treatment of various infections caused by susceptible microorganisms, including:

  • Upper respiratory tract infections such as sinusitis, otitis media, and tonsillitis.
  • Lower respiratory tract infections including bacterial pneumonias and bronchitis.
  • Urinary tract infections and pyelonephritis.
  • Skin and soft tissue infections, as well as gonococcal infections.
  • Intra-abdominal infections such as peritonitis, cholecystitis, and pelvic cellulitis.
  • Prophylaxis of surgical infections to reduce the incidence of post-operative wound infections.

Positive Impact of Ultracillin

Ultracillin has a positive impact on patients by effectively treating bacterial infections and relieving associated symptoms. By targeting a wide range of susceptible microorganisms, Ultracillin helps in the resolution of infections and promotes recovery.

Recommended Dosage

The dosage of Ultracillin varies based on the severity of the infection and the patient’s age. For adults, the typical dosage ranges from 1.5 to 3 grams per day, divided into doses administered every 6 to 8 hours. In less severe infections, dosing may occur every 12 hours. The maximum daily dose should not exceed 4 grams.

For children, infants, and neonates, the recommended dosage is usually 150 mg per kilogram of body weight per day, administered every 6 to 8 hours. In neonates during the first week of life, dosing may occur every 12 hours.

Common Side Effects

While Ultracillin is generally well-tolerated, some individuals may experience side effects, including:

  • Pain at the site of injection, especially with intramuscular administration.
  • Gastrointestinal symptoms such as diarrhea, nausea, and vomiting.
  • Skin reactions such as rash and itching.

Essential Precautions

Before using Ultracillin, it is important to consider the following precautions:

  • Contraindications: Ultracillin should not be used in individuals with a history of allergic reactions to penicillins.
  • Superinfection: Careful observation for signs of superinfection, including fungal overgrowth, is essential during treatment.
  • Overdosage: Overdosage of Ultracillin may lead to convulsions and hypersensitivity reactions. Close monitoring and appropriate therapy are necessary in such cases.

Dealing with Side Effects

To manage potential side effects of Ultracillin:

  • Pain at Injection Site: Apply a cold compress to the injection site to reduce discomfort.
  • Gastrointestinal Symptoms: Stay hydrated and consider over-the-counter medications to alleviate nausea and vomiting.
  • Skin Reactions: Keep the affected area clean and dry, and consult a healthcare professional if severe itching or rash occurs.


Ultracillin is a valuable medication used in the treatment of bacterial infections. Understanding its indications, dosage recommendations, potential side effects, and precautions is essential for both healthcare professionals and patients. By following proper guidelines and precautions, Ultracillin can be safely and effectively used to treat infections and promote recovery. Always consult healthcare providers for personalized advice and treatment recommendations based on individual medical needs and circumstances.