Understanding Proximexa 125mg and 250mg Suspension (Zinnat 125mg Suspension)

Proximexa and Zinnat are oral prodrugs of the bactericidal cephalosporin antibiotic cefuroxime, which is active against various types of bacteria. These medications come in the form of dry, white to off-white, tutti-frutti flavored granules for oral suspension. In this article, we’ll explore the important information about Proximexa 125mg and 250mg suspension (including Zinnat 125mg suspension) to help you understand its use, dosage, side effects, and more.

1. Qualitative and Quantitative Composition

Proximexa and Zinnat 125mg and Proximexa 250mg suspension contain granules of cefuroxime (as cefuroxime axetil) for oral suspension.

2. Therapeutic Indications

Proximexa and Zinnat are indicated for the treatment of infections caused by susceptible bacteria. These infections may affect various parts of the body, including the upper respiratory tract, lower respiratory tract, genitourinary tract, skin, soft tissues, and more. Some specific indications include:

  • Upper respiratory tract infections (e.g., ear, nose, and throat infections like otitis media, sinusitis, tonsillitis, and pharyngitis).
  • Lower respiratory tract infections (e.g., pneumonia and acute exacerbations of chronic bronchitis).
  • Genitourinary tract infections (e.g., pyelonephritis, cystitis, and urethritis).
  • Skin and soft tissue infections (e.g., furunculosis, pyoderma, and impetigo).
  • Treatment of early Lyme disease and prevention of late Lyme disease.
  • Uncomplicated gonorrhea (single dose of 1g).

3. Dosage and Administration

The dosage of Proximexa/Zinnat varies based on the specific infection and the age of the patient. It’s essential to follow your healthcare provider’s recommendations. Here are some general dosage guidelines:

For Adults:

  • Most infections: 250 mg twice daily.
  • Urinary tract infections: 250 mg twice daily.
  • Mild to moderate lower respiratory tract infections: 250 mg twice daily.
  • More severe lower respiratory tract infections or suspected pneumonia: 500 mg twice daily.
  • Pyelonephritis: 250 mg twice daily.
  • Uncomplicated gonorrhea: A single dose of 1g.
  • Lyme disease in adults and children over 12 years old: 500 mg twice daily for 14 days (range of 10-21 days).

For Children (3 months and older):

  • Dosage depends on the specific infection and the child’s weight.
  • There are no clinical trial data available for children under 3 months of age.

It’s important to use the correct measuring devices (measuring spoons or dosing syringes) for the 125 mg/5 ml or the 250 mg/5 ml multi-dose suspension, and 125 mg or 250 mg single-dose sachets.

4. Precautions and Potential Side Effects

Proximexa/Zinnat may cause some side effects. While these side effects are generally mild and transient, it’s important to be aware of them:

  • Common side effects include gastrointestinal disturbances (diarrhea, nausea, abdominal pain), headache, and dizziness.
  • Less common side effects include skin rashes, vomiting, and hypersensitivity reactions like urticaria or pruritus.
  • Rare side effects, although uncommon, can be more severe and include pseudomembranous colitis (diarrhea), jaundice, or hematological issues (e.g., thrombocytopenia).

If you experience severe side effects, seek medical attention immediately.

5. Special Precautions

  • If you are known to be allergic to penicillins or other beta-lactam antibiotics, inform your healthcare provider.
  • Prolonged use may lead to the overgrowth of non-susceptible organisms.
  • Patients may experience the Jarisch-Herxheimer reaction when treating Lyme disease.
  • The suspension contains aspartame, which is a source of phenylalanine, so use caution in patients with phenylketonuria.
  • The medication’s effectiveness can be affected by drugs that reduce gastric acidity, and it may reduce the efficacy of combined oral contraceptives.

6. Pharmacological Properties

Cefuroxime, the active ingredient in Proximexa and Zinnat, is effective against various bacteria, although susceptibility can vary by region and time. In vitro susceptibility varies depending on the microorganism.

Remember, this information provides a general overview of Proximexa 125mg and 250mg suspension (Zinnat 125mg suspension). Always consult your healthcare provider for specific guidance regarding your condition and treatment plan.