Understanding Pletaal: Your Simple Guide to Better Health

When it comes to managing health conditions, a combination of a healthy lifestyle and proper medication is often necessary. Pletaal is one such medication designed to address ischemic conditions that can significantly impact a person’s health and daily life. Let’s dive into the details, breaking down what Pletaal does, how it helps, and what you need to know.

What Pletaal Does

Active Ingredient: Pletaal contains Cilostazol as its main active ingredient, a quinoline derivative with selective inhibition of phosphodiesterase type 3. This component plays a crucial role in increasing the concentration of cyclic AMP in platelets and blood vessels.

Physicochemical Properties: Pletaal comes in various forms, including injection solution, tablets, and pills, all carrying the essential properties of Cilostazol.

Mechanism of Action: Cilostazol influences the contractile activity of smooth muscle cells, leading to the dilation of blood vessels. Additionally, it prevents platelets from sticking together, reducing the risk of blood clots. This action promotes smoother blood circulation through the arteries.

Indications for Pletaal

Pletaal is indicated for the treatment of the following conditions:

  1. Ischemic Disease Symptoms: Addresses symptoms like ulceration, pain, and cold extremities in chronic arterial obstruction, including conditions like Berger’s disease and occlusive arteriosclerosis.
  2. Cerebral Infarction Prophylaxis: Helps prevent recurrent cerebral infarction (excluding cardiac embolism).
  3. Improving Walking Distance: Maximizes pain-free walking distance improvement in patients with intermittent claudication without rest pain and without peripheral tissue necrosis.

Precautions: The efficacy of Pletaal on cerebral infarction hasn’t been studied in patients with asymptomatic cerebral infarction.

Understanding Side Effects

While Pletaal is generally well-tolerated, it’s essential to be aware of potential side effects. These can include manifestations of myocardial infarction, congestive heart failure, and bleeding tendency. Keep an eye out for symptoms such as intracranial hemorrhage, gastrointestinal bleeding, and lung-related adverse events.

Contraindications: Who Should Avoid Pletaal

Pletaal is contraindicated for individuals:

  • Sensitive or allergic to any of its ingredients.
  • At risk of bleeding or with a history of severe arrhythmia and congestive heart failure.
  • Experiencing renal failure syndrome or moderate to severe liver failure.

Special Caution: Pregnant women should use Pletaal cautiously due to limited studies on its effects on the fetus. Similarly, it’s not recommended for lactating women as it may be excreted in breast milk, posing a risk to infants.

How to Take Pletaal

Form and Dosage

  • Form: Pletaal comes in tablet form (Pletaal 50mg and Pletaal 100mg).
  • Dosage: The usual adult dose is 1 tablet x 2 times/day. Dosage may be adjusted based on age and symptom severity.

Administration Tips

  • Take orally at least 30 minutes before eating or 2 hours after meals.
  • Ensure you follow your doctor’s prescribed dose for your specific condition.

Overdose or Missed Dose

  • Overdose Symptoms: Severe headache, diarrhea, and heart palpitations. Seek immediate medical attention.
  • Missed Dose: Take it as soon as possible, but do not double the dose if close to the next scheduled dose.

Interactions with Other Medications

It’s crucial to inform your healthcare provider of all medications you’re taking to avoid interactions. Some antibiotics, antifungal agents, and macrolide antibiotics may interact with Pletaal. Avoid grapefruit juice as it can impact drug interactions.

Notes for Safe Use

  1. Precautions with Comorbidities: Use Pletaal cautiously if you have liver or kidney disease or if you’re taking medications like anticoagulants. Consult your doctor for advice.
  2. Pregnancy and Breastfeeding: Pregnant women should weigh the benefits and risks with a doctor. Breastfeeding women should avoid Pletaal due to potential risks to the baby’s health.
  3. Consistent Medication: Do not stop taking Pletaal without consulting your doctor.


Understanding how Pletaal works, its indications, and precautions is essential for effective and safe use. If you have any concerns or experience unusual symptoms, consult your healthcare provider promptly. Your well-being is a priority, and Pletaal is here to support you on your journey to better health.