Understanding Lasilactone: Your Comprehensive Guide

Lasilactone is a medication designed to address fluid accumulation in tissues (edema) or body cavities (e.g., ascites) with additional electrolyte disturbances due to excessive aldosterone levels (hyperaldosteronism). This comprehensive guide aims to simplify the medical information provided in the Patient Information Leaflet (PIL) and offer practical advice for individuals using Lasilactone.


Each film-coated tablet of Lasilactone 50mg contains 50 mg spironolactone in micronized form and 20 mg furosemide. Similarly, each film-coated tablet of Lasilactone 100mg contains 100 mg spironolactone and 20 mg furosemide.


Lasilactone is indicated for:

  • Fluid accumulation in tissues (edema) or body cavities (ascites).
  • Electrolyte disturbances due to excessive aldosterone levels (hyperaldosteronism).
  • Ascites due to liver diseases (e.g., cirrhosis).
  • Edema in tissues and cor pulmonale due to heart failure.
  • Edema in tissues in nephrotic syndrome.

Positive Impact of the Medicine

Lasilactone has a positive impact by addressing fluid accumulation and electrolyte disturbances. It is particularly effective in conditions such as ascites, edema due to heart failure, and nephrotic syndrome. The micronized form of spironolactone and furosemide work together to regulate aldosterone levels and promote diuresis.

Dosage Recommendations

For adults, the following dosage guidelines apply:

  • For the first 3 to 6 days, 1 tablet of Lasilactone up to 4 times daily, depending on the indication and severity of the condition.
  • For maintenance treatment, 1 tablet of Lasilactone up to 3 times daily is adequate. This dose may be taken every day, or every 2nd or 3rd day, as required.

It is advisable to swallow the tablet whole with a sufficient amount of liquid, preferably with breakfast or lunch. Avoid taking the drug in the evening, especially at the start of treatment, due to the increased urine excretion expected.

Common and Uncommon Side Effects

While Lasilactone is generally well-tolerated, it’s crucial to be aware of potential side effects. These may include:

Common Side Effects:

  • Gastrointestinal disorders (e.g., nausea, vomiting, diarrhea).
  • Transient rise in serum creatinine and urea.
  • Decrease in blood volume (hypovolemia) and sodium depletion (hyponatremia).
  • Dryness of the mouth and thrombophilia.
  • Fall in blood pressure sometimes progressing to circulatory collapse.
  • Feeling of weakness and circulatory disturbances such as dizziness, headaches, visual impairment, drowsiness, and calf cramps.

Uncommon Side Effects:

  • Increased tenderness of the nipples and breast enlargement in both sexes.
  • Vocal changes (hoarseness and deepening of the voice in women, heightening of the voice in men).
  • Menstrual irregularities and abnormal hair growth on face and body in women.
  • Disturbances of potency in men.
  • Lethargy and mental confusion after high doses.
  • Allergic reactions (e.g., skin rashes, vasculitis, fever, interstitial nephritis).
  • Changes in blood picture (hemolytic anemia, leukopenia, agranulocytosis, thrombocytopenia).
  • Increase in serum cholesterol and triglyceride levels under furosemide treatment.

It’s essential to consult a physician if any unexpected symptoms or discomfort occur.

Strategies for Managing Side Effects

  1. Stay Hydrated: Ensure an adequate intake of fluids to counteract potential dehydration.
  2. Regular Monitoring: If on long-term treatment, regularly monitor potassium, sodium, and urinary substances containing nitrogen.
  3. Voice Changes: If vocal changes occur, especially in individuals for whom voice is of professional importance (e.g., singers, teachers), weigh the therapeutic benefit against potential hazards.
  4. Seek Medical Advice: If experiencing any side effects, consult your healthcare provider promptly.


  • Correct severe potassium depletion before starting treatment.
  • In nursing mothers, breastfeeding should be stopped if Lasilactone has to be used.
  • Monitor serum potassium levels frequently in patients with impaired renal function.
  • Regularly monitor potassium, sodium, and urinary substances during long-term treatment.
  • Regularly monitor patients with hypertension on Lasilactone.
  • Use with caution in patients with disorders of hearing, as hearing defects may be rare but irreversible.


Lasilactone may interact with other drugs. Some important interactions include:

  • Excessive rise in serum potassium levels with potassium-containing drugs or ACE-inhibitors.
  • Reduced effect of carbenoxolone.
  • Interaction with salicylates (analgesics).
  • Potential potentiation or reduction of the potency of various drugs (e.g., antidiabetics, pressor amines, salicylates, theophylline, lithium, and curaremimetic muscle relaxants).
  • Potentiation of the nephrotoxic effects of certain antibiotics.

It’s crucial to inform your healthcare provider about all medications you are taking to avoid potential interactions.


Understanding Lasilactone and its applications in managing fluid accumulation and electrolyte disturbances is crucial for individuals facing conditions such as ascites, edema, and heart failure. By following prescribed dosages, staying informed about potential side effects, and actively managing any discomfort, patients can contribute to their overall well-being. Always consult with your healthcare provider for personalized advice tailored to your specific health needs. Remember, this guide is not a substitute for professional medical advice, diagnosis, or treatment.