Understanding Ketofan: Your Comprehensive Guide to Pain Relief and Inflammation Management

Ketofan, a medication containing Ketoprofen, belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs). With anti-inflammatory, analgesic, and antipyretic properties, Ketofan is widely used for various conditions, including rheumatic diseases, soft tissue injuries, and musculoskeletal pain. This guide aims to provide an in-depth understanding of Ketofan, covering its indications, dosage, precautions, side effects, and more.


Ketofan is indicated for the symptomatic treatment of:

  • Acute and chronic inflammatory rheumatic diseases (osteoarthritis, rheumatoid arthritis, ankylosing spondylitis)
  • Soft tissue injuries (tendinitis, bursitis)
  • Musculoskeletal pain associated with conditions like low back pain
  • Painful conditions arising from traumatic injuries
  • Primary dysmenorrhea (menstrual pain)

Dosage Recommendations

  • The dosage varies based on the condition being treated.
  • For traumatic injuries, musculoskeletal pain, and inflammatory rheumatic diseases, Ketofan is administered through deep intramuscular injection at a daily dose of 100 to 200 mg, divided into two separate injections for a duration of 2-3 days.
  • Maintenance treatment may involve a shift to oral forms after the initial injection phase.
  • It is essential to follow the prescribed dosage and duration recommended by the healthcare provider.


  1. Renal Impairment: Ketofan’s clearance is decreased in patients with renal impairment. Careful monitoring of urine volume and renal function is crucial, especially in patients with heart failure, cirrhosis, nephrotic syndrome, or chronic renal failure.
  2. Gastrointestinal Risks: NSAIDs, including Ketofan, pose an increased risk of serious gastrointestinal adverse events, such as bleeding, ulcers, and perforations. Patients with a history of gastroduodenal ulcers should exercise caution.
  3. Cardiovascular Risks: Ketofan may elevate the risk of cardiovascular events. Patients with cardiovascular diseases or risk factors should use Ketofan cautiously, and prolonged use may increase the risk.
  4. Hematological Effects: Ketofan may affect blood clotting, leading to an increased risk of bleeding. Caution is advised in patients on oral anticoagulants or with bleeding disorders.
  5. Hypersensitivity: Individuals with a known allergy to Ketoprofen or similar substances, such as aspirin, should avoid Ketofan. Allergic reactions, including asthma attacks, have been reported.

Side Effects

  1. Gastrointestinal Manifestations: Common side effects include gastralgia, abdominal pain, nausea, vomiting, constipation, and diarrhea. Serious effects like gastrointestinal hemorrhage and a decrease in glomerular filtration may occur.
  2. Central Nervous System: Headache, dizziness, blurred vision, and mood disorders are potential side effects. Patients should be cautious about activities requiring mental alertness.
  3. Dermatological Reactions: Photosensitivity, urticaria, rash, and pruritus have been reported. Severe skin reactions are rare but possible.
  4. Renal Effects: Ketofan may lead to acute renal failure, particularly in dehydrated patients. Adequate hydration and monitoring of renal function are essential.
  5. Cardiovascular and Hematological: Cardiovascular risks, including increased blood pressure, and hematological effects such as anemia and leukopenia, should be monitored.

Drug Interactions

  • Anticoagulants: Concomitant use with oral anticoagulants may increase the risk of bleeding. Monitoring of bleeding time is recommended.
  • Methotrexate: Ketofan should be stopped at least 12 hours before methotrexate treatment and should not be administered for at least 12 hours after the end of methotrexate therapy.
  • Lithium: Concomitant use may lead to an increase in plasma lithium levels, requiring careful monitoring.

Pregnancy and Pediatric Use

  • Ketofan crosses the placental barrier, and caution is advised during pregnancy.
  • Ketofan is not recommended for use in premature infants due to the benzyl alcohol content, which may lead to serious adverse effects.


Ketofan, with its potent anti-inflammatory and analgesic properties, serves as a valuable tool in managing various painful and inflammatory conditions. However, it is crucial for patients and healthcare providers to be aware of the potential risks and side effects associated with its use. Strict adherence to prescribed dosages, close monitoring for adverse effects, and prompt reporting of any unusual symptoms are essential for ensuring the safe and effective use of Ketofan. Always consult with a healthcare professional for personalized advice and guidance tailored to individual health conditions.

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