Understanding Curisafe: A Comprehensive Guide

Curisafe is a medication with various pharmaceutical forms designed to combat bacterial infections. This comprehensive guide aims to provide detailed insights into the composition, properties, indications, dosage, precautions, and practical tips for using Curisafe.


Curisafe is available in different pharmaceutical forms, each containing cefadroxil, a bactericidal first-generation cephalosporin.

  • Curisafe Tablets (1 g): Each tablet contains 1 g of cefadroxil activity.
  • Curisafe Capsules (500 mg): Each capsule contains 500 mg of cefadroxil activity.
  • Curisafe Powder for Oral Suspension: 5 ml of reconstituted suspension contains 125 mg, 250 mg, or 500 mg of cefadroxil activity.
  • Curisafe Pediatric Drops (100 mg/ml): 1 ml of reconstituted drops contains 100 mg of cefadroxil activity.


Cefadroxil, the active ingredient in Curisafe, exhibits bactericidal activity against both Gram-positive and Gram-negative microorganisms. It interferes with the terminal step in bacterial cell wall synthesis and is resistant to hydrolysis by β-lactamase, providing a broad spectrum of coverage.


After oral administration, Cefadroxil is well-absorbed and not affected by food. It is widely distributed in body tissues and fluids, with more than 90% excreted unchanged in the urine within 24 hours. The plasma half-life is about 1.5 hours but is prolonged in patients with impaired renal function.

Bactericidal Spectrum

Curisafe is effective against a range of Gram-positive and Gram-negative pathogens, making it a versatile choice for various infections.


Curisafe is indicated for infections caused by cefadroxil-susceptible strains, including:

  • Gram-positive pathogens (Staphylococci, Streptococci)
  • Gram-negative bacteria (Escherichia coli, Klebsiella, Proteus mirabilis, Haemophilus influenzae, Salmonella, Shigella)

It is used in the treatment of infections in respiratory, skin and soft tissues, urinary tract, genital tract, and other miscellaneous infections.

Dosage and Administration


  • Urinary Tract Infections: 1 or 2 grams per day.
  • Skin and Skin Structure Infections: 1 gram per day.
  • Pharyngitis and Tonsillitis: 1 gram per day for at least ten days.
  • Respiratory Tract Infections: 1 to 2 grams daily for moderate to severe infections.


  • Dosage: 25 to 50 mg/kg/day in two equally divided doses.
  • Specific Infections: Adjust dosage based on the type of infection.

Dosage adjustments are necessary for patients with renal impairment.

Reconstitution of Curisafe Powder

Detailed instructions for reconstitution of Curisafe powder for oral suspension and pediatric drops are provided. It’s crucial to follow these guidelines for proper administration.


Curisafe should not be used in individuals with hypersensitivity to cephalosporins and penicillins.


In patients with renal impairment, the dose must be reduced. Caution is recommended for individuals with a history of penicillin allergy due to cross-allergenicity between penicillins and cephalosporins.

Side Effects

Curisafe is generally safe but may cause gastrointestinal disturbances, including nausea, abdominal cramps, and diarrhea. Less common side effects include urticaria, skin rash, angioneurotic edema, and transient leucopenia.

Pregnancy and Lactation

Use during pregnancy and lactation is advised only if clearly indicated.

Drug Interactions

Curisafe may interact with probenecid, aminoglycosides, and warfarin, necessitating caution and monitoring.

Overdosage and Treatment

Accidental ingestion of high doses may cause symptoms like diarrhea, abdominal pain, nausea, and vomiting. Treatment involves gastric lavage, activated charcoal intake, hemodialysis, and symptomatic management.

Packing and Storage

Curisafe is available in different packing configurations, and it should be stored at room temperature away from moisture. Always check the expiry date and keep it out of the reach of children.


Understanding Curisafe is essential for those prescribed this medication. By delving into its composition, properties, indications, dosage, precautions, and practical tips, users can navigate their treatment journey more effectively. Always consult healthcare professionals for personalized advice based on individual health conditions.