Understanding CELEBREX 200 mg Capsules: Uses, Dosage, and Precautions

If you’ve been prescribed CELEBREX 200 mg capsules, it’s essential to understand how this medication works and how to use it safely. In this article, we’ll break down the key information about CELEBREX, focusing on its indications, dosage, and important precautions.

What is CELEBREX 200 mg Capsule and When Is It Used?

CELEBREX belongs to a class of medications known as non-steroidal anti-inflammatory drugs (NSAIDs), specifically in the subgroup of cyclooxygenase-2 (COX-2) inhibitors. Your body produces prostaglandins that can cause pain and inflammation. In conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, your body produces more prostaglandins. CELEBREX works by reducing the production of prostaglandins, which, in turn, decreases pain and inflammation.

CELEBREX is prescribed to adults to relieve the signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It’s important to note that while the medication may start working within hours of the first dose, it may take a few days of treatment to achieve its full effect.

Important Information Before Taking CELEBREX 200 mg Capsule

Before using CELEBREX, there are crucial considerations to keep in mind. It’s important to follow your doctor’s recommendations closely. Here are some key points to remember:

When Not to Take CELEBREX:

  • If you are allergic to célécoxib or any other components mentioned in the leaflet.
  • If you have a history of allergies to sulfonamides (a class of antibiotics).
  • If you have an ulcer or bleeding in your stomach or intestines.
  • If you have a history of asthma, nasal polyps, severe nasal congestion, or an allergic reaction to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs).
  • During pregnancy, unless advised otherwise by your doctor.
  • While breastfeeding.
  • If you have severe liver disease.
  • If you have severe kidney disease.
  • If you have inflammatory bowel diseases like ulcerative colitis or Crohn’s disease.
  • If you have congestive heart failure, documented coronary artery disease, or cerebrovascular disease (e.g., stroke, transient ischemic attack).
  • If you have or have had issues with blood circulation (peripheral artery disease) or a history of leg artery surgery.

Warnings and Precautions:

  • If you have a history of ulcers or bleeding in the stomach or intestines.
  • If you use low-dose aspirin for heart protection.
  • If you take medications that reduce blood clotting.
  • If you use corticosteroids like prednisone.
  • If you take other NSAIDs, except aspirin.
  • If you have a history of smoking, diabetes, high blood pressure, or high cholesterol.
  • In case of heart, liver, or kidney diseases, regular monitoring by your doctor is essential.
  • If you experience fluid retention (swollen ankles and feet).
  • If you are dehydrated due to illness, diarrhea, or diuretic use.
  • If you’ve had allergic reactions or severe skin reactions to medications.
  • If you feel unwell due to an infection, as CELEBREX may mask fever and other signs of infection or inflammation.
  • For individuals aged 65 or older, your doctor may closely monitor you.
  • The consumption of alcohol alongside NSAIDs can increase the risk of gastrointestinal problems.

Remember, as with other NSAIDs, CELEBREX may lead to an increase in blood pressure. Therefore, your doctor may regularly monitor your blood pressure.

Interaction with Other Medications:

Inform your doctor or pharmacist about any other medications you are taking, including:

  • Dextromethorphan (cough medicine).
  • Medications for blood pressure, heart conditions, and diuretics.
  • Antifungal and antibacterial drugs like fluconazole and rifampicin.
  • Anticoagulants (blood thinners) such as warfarin.
  • Lithium (used to treat depression).
  • Medications for depression, sleep disorders, high blood pressure, or irregular heart rhythms.
  • Neuroleptics (used in certain mental health conditions).
  • Methotrexate (for rheumatoid arthritis, psoriasis, or leukemia).
  • Carbamazepine (used for epilepsy, seizures, certain types of pain, or depression).
  • Barbiturates (used in epilepsy, seizures, and sleep disorders).
  • Immunosuppressive drugs like ciclosporin and tacrolimus (used after organ transplantation).

CELEBREX can be taken with low doses of aspirin (75 mg per day or less), but it’s essential to consult your doctor before using these two medications together.

Pregnancy, Breastfeeding, and Fertility:

  • Do not take CELEBREX during the last three months of pregnancy unless advised otherwise by your doctor, as it may harm the unborn child.
  • If you are trying to become pregnant, are pregnant, or breastfeeding, consult your doctor before taking CELEBREX.

Dosage and Administration:

Your doctor will prescribe the appropriate dose for your specific condition. In general, the typical adult dosage for the management of osteoarthritis and rheumatoid arthritis is 100 to 200 mg daily, divided into one or two doses. For ankylosing spondylitis, the usual adult dose is 200 mg daily, taken as one or two divided doses.

Follow your doctor’s instructions and do not exceed the prescribed dosage. CELEBREX should be taken with food or milk to help reduce the risk of stomach upset. Swallow the capsule whole; do not break, crush, or chew it.

Potential Side Effects:

Common side effects may include upset stomach, diarrhea, and swelling of the legs, ankles, or feet. However, if you experience severe side effects, such as difficulty breathing, chest pain, slurred speech, or weakness on one side of your body, seek medical attention immediately.


CELEBREX 200 mg capsules are used to manage pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. To ensure the safe and effective use of this medication, follow your doctor’s instructions, be aware of potential interactions and side effects, and adhere to the recommended precautions.

Always consult your healthcare provider for personalized advice and guidance regarding your specific condition and medication regimen. This article serves as a general informational guide and should not replace professional medical advice.