Understanding BENCILLIN-5: Your Guide to Benzylpenicillin Injection

Before embarking on any medication journey, it’s vital to be well-informed. In this guide, we’ll delve into the details of BENCILLIN-5, a Benzylpenicillin For Injection BP, and explore its uses, dosage, possible side effects, and proper storage. Read on to get a clearer picture of this medication.

What is BENCILLIN-5 and its Indications

What is Benzylpenicillin Injection?

BENCILLIN-5, or Benzylpenicillin Injection, is an important medication in the realm of antibiotics. Its active ingredient, benzylpenicillin sodium (also known as penicillin G), belongs to the penicillin family of antibiotics. These antibiotics are your body’s trusted allies in fighting bacterial infections.

What does it treat?

Benzylpenicillin sodium proves effective in treating infections affecting various parts of the body, including:

  • Ear
  • Nose
  • Throat
  • Chest
  • Heart
  • Bones
  • Skin

But the uses of this medication don’t stop there. It can also be employed in the treatment of:

  • Sexually transmitted infections like gonorrhoea and syphilis
  • Meningitis
  • Brain abscesses
  • Gangrene (decay and tissue death due to poor blood supply)
  • Blood infections
  • Anthrax (an infection stemming from animals)
  • Tetanus
  • Diphtheria (acute infections/diseases of the respiratory tract)
  • Listeria (a type of food poisoning)
  • Leptospirosis (an infection originating from animals)
  • Pasteurellosis (an infection following animal bites)
  • Severe Lyme disease (an infection from tick bites)
  • Actinomycosis (an infection caused by trauma or surgery)
  • Infections resulting from rat bites

Furthermore, Benzylpenicillin sodium is administered to prevent infections in newborn babies, specifically against group B streptococcal infection.

Before Using BENCILLIN-5

Allergies and Special Considerations

Before starting your journey with BENCILLIN-5, it’s essential to be aware of certain conditions and considerations:

  • Allergies: If you are allergic to benzylpenicillin sodium, other antibiotics, or any of the other components in this medication, it’s important not to use it.
  • Special Care: If you have other allergies, especially to medicines, are pregnant, breastfeeding, or suspect you might be pregnant, have kidney or liver problems, heart issues, or diabetes, let your healthcare provider know.

Interactions with Other Medications

It’s crucial to inform your healthcare provider about any other medications you are currently taking or have recently taken, even if they were obtained without a prescription. Some medicines may interact with BENCILLIN-5, such as oral contraceptives, probenecid, methotrexate, allopurinol, sulfinpyrazone, neomycin, anticoagulants, and oral typhoid vaccine.

Probenecid, for instance, can extend the effects of Benzylpenicillin, while BENCILLIN-5 might impact the efficacy of oral contraceptives, potentially leading to unplanned pregnancies. It’s also worth noting that penicillins can affect the outcomes of certain urine and blood tests.


Dosage Guidelines

The dosage of BENCILLIN-5 varies depending on the patient’s age and the nature of the infection. It is typically administered intramuscularly (into the muscle) or intravenously (into a vein). Here are the general dosage recommendations:

  • Adults: For most infections, a typical daily dose ranges from 600mg to 3,600mg. In severe cases like meningitis and gangrene, higher daily doses of up to 14,400mg and 43,200mg, respectively, may be required.
  • Suspected Meningitis: In cases of suspected meningitis, a single dose of 1,200mg is often administered for adults and children over 10 years.
  • Prevention of Infection During Labor: For the prevention of group B streptococcal infection in newborns, mothers receive 3,000mg of Benzylpenicillin, followed by 1,500mg every four hours until delivery.

Special Cases

For adults with kidney problems, the dosage may be adjusted after conducting necessary tests. The same applies to elderly patients, who might receive lower doses.


The dosage for children, babies, and infants is based on their weight, ranging from 50mg to 100mg per kg of body weight per day, depending on the age and severity of the infection.

Premature Babies and Neonates:

These groups may also receive lower doses.

Overdose Precautions

Using excessive amounts of BENCILLIN-5 can lead to severe side effects, including irritation of the brain and convulsions, especially in patients with poor kidney function. Always stick to the prescribed dosage.

Potential Side Effects

As with any medication, BENCILLIN-5 can cause side effects in some individuals. If you experience any of the following side effects, contact your healthcare provider immediately:

  • Skin rash or itchy skin
  • Difficulty in breathing or chest tightness
  • Swelling of eyelids, face, or lips
  • Redness or swelling of the tongue
  • Fever
  • Joint pains
  • Swollen lymph nodes

Long-term use or high doses of BENCILLIN-5 may also result in additional side effects such as reduced blood cell count, anemia, changes in blood electrolyte levels, kidney inflammation, skin irritation, fever, headache, sore throat, muscle soreness, fast heartbeat (particularly in syphilis treatment), diarrhea (with rare instances of blood in the stool), fungal infections, and seizures.


Proper Storage

To ensure the effectiveness and safety of BENCILLIN-5, adhere to these storage instructions:

  • Keep it out of the sight and reach of children.
  • Store it in a dry place at a temperature below 30°C.
  • Protect it from light.

After mixing the content of the vial with an injection solution, use it immediately. Never use a bottle after the expiry date printed on the label, as it refers to the last day of that month. Remember to dispose of medicines correctly by consulting your pharmacist, which not only ensures your safety but also contributes to environmental protection.


BENCILLIN-5, or Benzylpenicillin Injection, is a powerful tool in the fight against bacterial infections. By understanding its uses, dosages, potential side effects, and proper storage, you can make the most of this medication while ensuring your safety and well-being. If you have any doubts or concerns regarding BENCILLIN-5, don’t hesitate to consult your healthcare provider for guidance and peace of mind. Your health is a precious asset, and this medication is here to help you safeguard it.

Description of BENCILLIN-5 and Packaging

Let’s take a closer look at the appearance and packaging of BENCILLIN-5:

  • Appearance: BENCILLIN-5 presents itself as a white or nearly white crystalline powder.
  • Packaging: Each package consists of a carton containing 50 vials of BENCILLIN-5 injection, accompanied by an informative leaflet.

Marketing Authorization and Manufacturing Details

For your reference, here are the key details regarding marketing authorization and manufacturing:

  • Marketing Authorization Holder:
    • Company: Bliss GVS Pharma Ltd.
    • Address: 102, Hyde Park, Saki-Vihar Road, Andheri (East), Mumbai – 400 072, India
  • Manufactured By:
    • Company: Inject Care Parenterals Pvt. Ltd.
    • Address: Plot No. 130, Silvassa Road, G.I.D.C., Vapi, City-Vapi, -396195, Dist. Valsad, Gujarat State, India