Understanding AZITRO: A Comprehensive Guide

You may have come across the term “AZITRO 500 mg Lyophilized Powder for Solution for IV Infusion” and wondered what it is and how it is used. In this guide, we’ll explore AZITRO, its uses, precautions, and potential side effects, providing you with valuable information about this medical product.


AZITRO is a medication available in the form of a lyophilized powder for solution for intravenous (IV) infusion. It is sterile and contains an active substance known as azithromycin, which belongs to a class of antibiotics called macrolides. This antibiotic acts by stopping or eliminating bacteria that cause infections. It’s important to note that AZITRO is not effective against viral infections like the common cold or flu.

Common Uses of AZITRO:

AZITRO is prescribed for the treatment of various infections, including:

  • Respiratory Infections: Such as bronchitis, pneumonia, tonsillitis, sore throat, and sinusitis.
  • Ear Infections
  • Skin and Soft Tissue Infections: Including abscesses and boils.
  • Sexually Transmitted Diseases (STDs): Specifically, those caused by the bacterium chlamydia.
  • Pelvic Inflammatory Disease: An inflammation of the uterus and ovaries.

Precautions and What You Need to Know:

Who Should Avoid AZITRO?

You should not take AZITRO if you:

  • Are allergic to azithromycin, erythromycin, clarithromycin, or related antibiotics.
  • Have a history of liver problems or yellowing of the skin and eyes with any form of azithromycin.
  • Experience severe liver impairment.
  • Have kidney problems (your doctor may need to adjust the dose if you have severe kidney failure).
  • Suffer from heart conditions or heart rhythm abnormalities.
  • Are taking specific medications that affect heart rhythm or blood potassium levels.
  • Have Myasthenia gravis, a nerve-muscle disease causing muscle weakness and fatigue.
  • Use certain medications like ergotamine (for migraines) or class IA and III antiarrhythmics.
  • Have low blood potassium or magnesium levels.
  • Are elderly.

AZITRO and Pregnancy:

Consult your doctor or pharmacist if you are pregnant. AZITRO should only be used during pregnancy if it is absolutely necessary. If you discover that you are pregnant while taking AZITRO, consult your healthcare provider immediately.

AZITRO and Breastfeeding:

For breastfeeding mothers, AZITRO should only be used when absolutely necessary, as there is limited information about whether azithromycin is excreted in human milk.

Using AZITRO with Other Medications:

Inform your doctor if you are taking any of the following medications:

  • Warfarin (used to prevent blood clotting)
  • Cyclosporine (an immunosuppressant)
  • Digoxin (used in heart failure)
  • Medications for migraine, allergies, asthma, or AIDS
  • Any other medications, including non-prescription ones

How AZITRO Is Administered:

AZITRO is typically administered by healthcare professionals, and you should never attempt to administer it yourself.

Preparation and Dilution:

The initial solution of AZITRO is prepared by adding sterile water to the lyophilized powder, and the exact volume must be ensured using a standard syringe. The reconstituted solution is further diluted before administration with compatible diluents. The specific instructions should be followed carefully.

Dosage and Age Groups:

The dosage and administration of AZITRO depend on your condition and age:

  • Adults: AZITRO is recommended for adults.
  • Children: The safety and efficacy of intravenous AZITRO in children under 16 years have not been determined.

Special Conditions:

  • Kidney Failure: AZITRO generally does not require dose adjustment for mild to moderate kidney failure, but caution is needed in severe cases.
  • Liver Failure: AZITRO should be used with caution in patients with severe liver failure.

Potential Side Effects:

All medications, including AZITRO, can cause side effects. These side effects are classified based on their frequency:

Common Side Effects:

  • Rash, itching, hives on the skin
  • Diarrhea, sometimes bloody or slimy, with stomach pain and fever

Uncommon Side Effects:

  • Swelling on the face, lips, tongue, or body, along with shortness of breath
  • Yellowing of the eyes and skin (jaundice)
  • Chest pain
  • Fainting
  • Seizures

These are serious side effects, and if experienced, seek immediate medical attention.

Other Possible Side Effects:

Various mild side effects can occur, such as:

  • Pain and inflammation at the injection site
  • Vaginal infection (thrush)
  • Nausea, vomiting, and stomach pain
  • Skin rash

It’s essential to inform your healthcare provider about any side effects you may experience, even if they seem mild.

Reporting Side Effects:

If you experience side effects from AZITRO, it’s crucial to report them to your healthcare provider. This helps ensure the safety of the medication and your overall well-being.

Storing AZITRO:

  • Keep AZITRO out of reach of children in its original packaging.
  • Store the vial at room temperature below 30°C before reconstitution.
  • Once reconstituted, AZITRO is stable for a limited time when stored below 30°C or between 2-8°C. Follow the specific instructions for dilution and storage provided by your healthcare provider.


AZITRO is a medication used to treat various bacterial infections. If prescribed AZITRO, follow your healthcare provider’s guidance carefully and report any unusual side effects. It’s essential to discuss your medical history, pregnancy, breastfeeding, and other medications you may be taking with your healthcare provider to ensure safe and effective treatment.