Understanding Acne Treatment with ACNOTIN

Acne is a common skin condition that can affect people of all ages, but when it becomes severe and resistant to other treatments, a medication like ACNOTIN may be prescribed. In this article, we will explore what ACNOTIN is, how to use it, possible side effects, and important considerations for patients.

What is ACNOTIN?

ACNOTIN contains isotretinoin, a substance related to vitamin A. It belongs to a group of medications called retinoids, which are primarily used for the treatment of acne. ACNOTIN is specifically indicated for severe types of acne, such as nodular or conglobate acne, or acne that poses a risk of causing permanent scarring. It is intended for use in adults and adolescents over 12 years old after puberty. ACNOTIN is prescribed when acne has not improved with other anti-acne treatments, including antibiotics and topical products.

Before Taking ACNOTIN

Before starting a course of ACNOTIN, there are some essential considerations:

Who Should Not Take ACNOTIN?

  • Individuals who are allergic to isotretinoin or any of its components should avoid taking ACNOTIN.
  • Pregnant or breastfeeding women should not use ACNOTIN due to the potential harm it can cause to an unborn or nursing baby.
  • People with liver disease, high cholesterol or triglycerides, and high levels of vitamin A in their body should refrain from using ACNOTIN.
  • If you are undergoing treatment with tetracyclines, a type of antibiotic, consult your healthcare provider before starting ACNOTIN.

Special Care and Mental Health

Before taking ACNOTIN, inform your doctor if you have ever experienced mental health issues, including depression, mood changes, or thoughts of self-harm, as your mood may be affected during treatment.

Pregnancy Prevention Program

ACNOTIN can be harmful to an unborn baby, causing severe abnormalities. To prevent pregnancy during treatment, strict rules apply:

  • Your doctor will discuss the risks and provide information on contraception methods.
  • Before starting ACNOTIN, you will undergo a pregnancy test to confirm you are not pregnant.
  • Effective contraception, such as hormonal birth control and condoms, is necessary before, during, and for one month after ACNOTIN treatment.
  • Regular pregnancy tests and follow-up visits are mandatory.

Advice for Men

While ACNOTIN poses no risk to the unborn babies of partners, it should never be shared with others. Unused capsules should be returned to the pharmacist.

Additional Precautions

  • Avoid donating blood during ACNOTIN treatment and for one month afterward to prevent harm to a pregnant recipient.
  • Be mindful of mood and behavior changes, and inform friends and family about your medication.
  • Discuss any history of mental illness, as well as any skin reactions, with your doctor.
  • ACNOTIN can cause muscle and joint pain, so reduce intensive physical activity while taking it.
  • Inflammatory bowel disease can be associated with ACNOTIN use.
  • ACNOTIN may lead to dry eyes, contact lens intolerance, and visual difficulties. Consult your doctor if you experience these symptoms.

Children and Adolescents

ACNOTIN is generally not recommended for children under 12, as its safety and efficacy in this age group are uncertain. It is primarily intended for use in adolescents aged 12 and older after puberty.


When taking ACNOTIN, it is crucial to follow your healthcare provider’s instructions carefully:


The usual starting dose is 0.5 mg per kilogram of body weight per day. Your doctor may adjust your dose based on your response to the medication. The duration of treatment typically lasts for 16 to 24 weeks, and most patients only require one course. It is essential to avoid intense physical activity, which can worsen bone and muscle issues.

Missed Doses

If you miss a dose, take it as soon as possible. However, if your next dose is near, skip the missed one and continue your regular schedule. Do not double the dose to make up for a missed one.

Stopping ACNOTIN

Do not stop taking ACNOTIN without consulting your doctor or pharmacist.

Possible Side Effects

Like all medications, ACNOTIN may have side effects, although not everyone will experience them. Some of these side effects can be serious and require immediate medical attention. Here are some of the possible side effects associated with ACNOTIN:

Serious Skin Rashes

Some individuals may experience serious skin rashes that require immediate medical attention. These rashes can be life-threatening and often manifest as circular patches with blisters, typically on the arms, hands, legs, and feet.

Mental Health Effects

ACNOTIN has been associated with mental health issues, including depression, mood alterations, and even thoughts of self-harm or suicide. Contact your doctor if you notice any changes in your mental well-being.

Allergic Reactions

In rare cases, ACNOTIN may trigger serious allergic reactions, leading to difficulty breathing, swelling of the throat, face, lips, mouth, hands, feet, and ankles. Immediate medical help is essential if you experience these symptoms.

Bone and Muscle Problems

Muscle weakness, swelling, bruising, dark-colored urine, and reduced urine output can be signs of rhabdomyolysis, a breakdown of muscle tissue potentially leading to kidney failure.

Liver and Kidney Issues

Yellowing of the skin or eyes and extreme tiredness could indicate hepatitis. Difficulty urinating, swollen eyelids, and excessive fatigue may suggest kidney inflammation.

Nervous System Problems

Headaches, nausea, vomiting, and blurred vision may be symptoms of benign intracranial hypertension, particularly if ACNOTIN is taken with antibiotics called tetracyclines.

Gut and Stomach Problems

Severe abdominal pain, bloody diarrhea, nausea, and vomiting could signal serious gut conditions.

Eye Disorders

Blurred vision and other vision-related problems should be reported to your doctor.

Other Side Effects

ACNOTIN may also cause various other side effects, including skin dryness, back pain, muscle pain, joint pain, elevated liver enzymes, changes in blood fats, and more.

It is important to inform your healthcare provider if you experience any side effects during ACNOTIN treatment.

How to Store ACNOTIN

ACNOTIN should be stored below 30°C in a dry place, away from direct sunlight. Keep it out of reach of children and do not use it after the expiry date stated on the packaging.


ACNOTIN is a medication prescribed for severe and treatment-resistant acne. While it can be highly effective, it comes with potential side effects and strict guidelines for use, especially concerning pregnancy prevention. If you are considering ACNOTIN for acne treatment, it is essential to discuss the potential risks and benefits with your healthcare provider. Always follow your doctor’s instructions and report any side effects promptly. Your health and well-being should be the top priority in managing acne and its treatment.