Simvaxibe Film Coated Tablets – Ezetimibe/Simvastatin Combination

  • Active Constituents: Ezetimibe/Simvastatin.
  • Avialable in there forms: 10/10 mg,  10/20 mg, and  10/40 mg Film Coated Tablets.
  • Recommended dosage: One Tablet Once Daily


Simvaxibe Film Coated Tablets
Simvaxibe Film Coated Tablets
  • Recommended by ESC 2019 Guidelines.
  • Exceeding the result of atorvastatin & rosuvastatin in LDL-C reduction in comparable doses.
  • Outperforming in achieving LDL-c goals specially in high risk patients compared with atorvastatin & rosuvastatin.
  • Providing a significant reduction in MACE* against Simvastatin monotherapy.
  • No added risk of any adverse event to statin monotherapy.
  • High compliance with friendly administrating dosage.
  • Cost-effective Product.

Dosage & Administration

  • Dose range is 10/10 mg/day to 10/40 mg/day. Recommended usual starting dose is 10/10 or 10/20 mg/day.
  • Should be taken as a single daily dose in the evening, with or without food.

Abbreviated Prescribing Information

  • Product Name: Simvaxibe, which contains a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor (statin).
  • Indication: indicated as adjunctive therapy to diet to: reduce elevated total-C, LDL-C, Apo B, TG, and non-HDL-C, and to increase HDL-C in patients with primary hyperlipidemia or mixed hyperlipidemia.
  • Dosage And Administration: Dose range is 10/10 mg/day to 40/10 mg/day. Recommended usual starting dose is 10/10 or 20/10 mg/day.


  • Concomitant administration of strong CYP3A4 inhibitors.
  • Concomitant administration of gemfibrozil, cyclosporine, or danazol.
  • Hypersensitivity to any component of this medication.
  • Active liver disease.
  • Pregnancy & nursing mother.

Adverse Reactions

  • headache.
  • increased ALT.
  • myalgia.
  • upper respiratory tract infection.
  • diarrhea.

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