SEPTRIN: A Comprehensive Guide to the Oral Antibiotic

In the world of medicine, antibiotics play a crucial role in treating various bacterial infections. One such antibiotic is SEPTRIN, a combination of trimethoprim and sulfamethoxazole. This blog post aims to provide a comprehensive analysis of SEPTRIN, its composition, clinical applications, dosage, precautions, and potential adverse reactions. So let’s dive in and explore the world of SEPTRIN!

Qualitative and Quantitative Composition

SEPTRIN is available in several oral presentations, each containing different amounts of trimethoprim and sulfamethoxazole. Here’s a breakdown of the composition:

  • Adult Tablet:
    • Trimethoprim content: 80 mg
    • Sulfamethoxazole content: 400 mg
  • Dispersible Tablet:
    • Trimethoprim content: 80 mg
    • Sulfamethoxazole content: 400 mg
  • Double Strength (Forte) Tablets:
    • Trimethoprim content: 160 mg
    • Sulfamethoxazole content: 800 mg
  • Paediatric Tablets:
    • Trimethoprim content: 20 mg
    • Sulfamethoxazole content: 100 mg
  • Capsules:
    • Trimethoprim content: 80 mg
    • Sulfamethoxazole content: 400 mg
  • Adult Oral Suspension:
    • Trimethoprim content: 80 mg per 5 ml
    • Sulfamethoxazole content: 400 mg per 5 ml
  • Paediatric Oral Suspension:
    • Trimethoprim content: 40 mg per 5 ml
    • Sulfamethoxazole content: 200 mg per 5 ml

Clinical Particulars and Indications

SEPTRIN is indicated for the treatment of various bacterial infections. However, it should only be used when the benefits outweigh any potential risks, and consideration should be given to using a single effective antibacterial agent when appropriate. Here are some of the common clinical indications for SEPTRIN:

Urinary Tract Infections

  • Treatment of acute uncomplicated urinary tract infections.
  • Initial episodes of uncomplicated urinary tract infections are often treated with a single effective antibacterial agent instead of a combination.

Respiratory Tract Infections

  • Treatment of otitis media.
  • SEPTRIN is not indicated for prophylactic or prolonged administration in otitis media.
  • Treatment of acute exacerbations of chronic bronchitis.
  • Treatment and prevention of Pneumocystis jiroveci (P. carinii) pneumonitis.

Genital Tract Infections

  • Treatment of gonorrhea, including oro-pharyngeal and ano-rectal infection.
  • Treatment of chancroid.
  • Treatment of granuloma inguinale.

Gastrointestinal Tract Infections

  • Treatment of cholera, as an adjunct to fluid and electrolyte replacement when the organism is sensitive in vitro.
  • Treatment of shigellosis.
  • Treatment of travelers’ diarrhea, including gastroenteritis due to enterotoxigenic E. coli.

Other Bacterial Infections

  • SEPTRIN may be useful in the treatment of nocardiosis, toxoplasmosis, brucellosis (as second-line therapy in combination with gentamicin or rifampicin), and melioidosis (in combination with ceftazidime or cefoperazone/sulbactam).

Please note that the local situation and bacterial susceptibility should always be considered when selecting antibiotic therapy.

Dosage and Administration

The dosage of SEPTRIN varies depending on the age group and the specific condition being treated. It is important to follow the prescribed dosage instructions provided by the physician or healthcare professional. Here’s a general overview of the recommended dosages:

Acute Infections (Adults and Children over 12 years):

  • Tablets/Capsules (Standard Dosage):
    • 2 tablets every 12 hours
    • 1 tablet every 12 hours for double-strength tablets
    • 10 ml every 12 hours for adult suspension

Acute Infections (Children aged 12 years and under):

  • Paediatric Tablets:
    • 4 tablets every 12 hours for ages 6 to 12 years
    • 2 tablets every 12 hours for ages 6 months to 5 years
    • 2.5 ml every 12 hours for ages 6 weeks to 5 months

The duration of treatment may vary depending on the condition being treated. It is important to continue treatment until the patient has been symptom-free for at least two days, with the majority requiring treatment for at least 5 days. If there is no improvement after 7 days of therapy, reassessment by a healthcare professional is recommended.

Precautions and Potential Adverse Reactions

While SEPTRIN is generally well-tolerated, there are certain precautions and potential adverse reactions that should be considered. Here are some important points to keep in mind:

  • SEPTRIN should not be given to patients with a history of hypersensitivity to sulphonamides, trimethoprim, co-trimoxazole, or any excipients of SEPTRIN.
  • It should be used with caution in elderly patients and those with impaired kidney and/or liver function, as they may be more susceptible to adverse reactions.
  • Regular monitoring of blood counts, especially for folate-deficient patients or those receiving long-term high-dose SEPTRIN, is advisable.
  • SEPTRIN should be used with caution in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, as hemolysis may occur.
  • Patients with severe allergy or bronchial asthma should be given SEPTRIN with caution.
  • It should not be used in the treatment of streptococcal pharyngitis caused by Group A beta-hemolytic streptococci.
  • SEPTRIN may interact with other medications, such as diuretics, zidovudine, warfarin, phenytoin, and sulfonylurea hypoglycemic agents. Close monitoring is advised in such cases.

Adverse reactions to SEPTRIN can occur, although they are generally rare. Some possible adverse reactions include nausea, diarrhea, skin rashes, hypersensitivity reactions (e.g., Stevens-Johnson syndrome), blood disorders, and hepatic or renal impairment. If any adverse reactions are observed, it is important to discontinue the medication and seek medical attention.


SEPTRIN, a combination of trimethoprim and sulfamethoxazole, is a commonly prescribed oral antibiotic used to treat a range of bacterial infections. It is important to follow the prescribed dosage instructions and consider the potential adverse reactions and precautions associated with its use. As with any medication, consulting a healthcare professional is essential to ensure safe and effective treatment.

Remember, this blog post provides a general overview of SEPTRIN, but it is always recommended to consult a healthcare professional or refer to the product’s specific prescribing information for precise and up-to-date guidelines.

Note: The information provided in this blog post is for educational purposes only and should not replace professional medical advice. Always consult a healthcare professional for specific medical guidance.

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