Rosuvast to prevent cardiovascular events by lowering blood fats

Rosuvast belongs to a class of medicines known as statins. Rosuvast works by blocking the production of cholesterol (blood fat) in the body, thereby reducing the amount of cholesterol that may build up on artery walls and block blood flow to the heart, brain and other parts of the body.

The accumulation of cholesterol and fat on the walls of the arteries, a process known as atherosclerosis, reduces blood flow through the arteries, thus reducing the supply of oxygen to the heart, brain and other parts of the body.

Using Rosuvast can lower the level of cholesterol and lipids in the blood, which contributes to preventing heart disease, angina (chest pain), strokes, and heart attacks.

Rosuvast is used together with diet, weight loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance of heart surgery in people who have heart disease or who are at risk of heart disease.


Rosuvastatin is the sientific name for Rosuvast, which is a drug that works by blocking the enzyme responsible for the synthesis of cholesterol in the liver, and it belongs to a class of drugs called statins.

Rosuvast is used to treat:

  • Hypercholesterolemia in adults, adolescents and children over 6 years of age.
  • Prevention of cardiovascular events in patients at high risk for new cardiovascular events.

Dosage and method of administration

Rosuvast can be taken at any time of the day, regardless of meals. Take your dose at the same time each day.

Starting dose: 5 mg or 10 mg once daily. If necessary, the dose may be adjusted after 4 weeks until the next higher dose. Maximum dose: 40 mg rosuvastatin once daily.

Side effects and contraindications

The following side effects have frequently occurred during treatment with Rosuvast: elevated blood sugar levels; headache and dizziness; constipation, nausea, abdominal pain; muscle pain and loss of strength – the frequency of side effects often depends on the dose.

Rosuvast is contraindicated in the following cases:

  • Known hypersensitivity to rosuvastatin;
  • active liver disease, including unexplained and persistent elevations of transaminases (liver enzymes) in the blood, and any elevation of transaminases in the blood greater than 3 times the upper limit of normal;
  • severe renal impairment (creatinine clearance <30 ml/min);
  • myopathy;
  • simultaneous treatment with cyclosporine;
  • Pregnancy, lactation and women of childbearing age who are not using appropriate contraceptive methods.

Doses of 30 mg and 40 mg are contraindicated in patients with predisposing factors for myopathy/rhabdomyolysis. These factors include:

  • Mild renal impairment (creatinine clearance <60 mL/min)
  • Hypothyroidism
  • Personal or family history of muscle disorders
  • The muscle-damaging effects of previous use of fibrates or other statins
  • heavy alcohol consumption
  • Simultaneous use of fibrates.

Instructions for use

Rosuvast comes in the form of tablets taken orally, usually the dose of Rosuvast is once a day in the evening, or according to the doctor’s instructions, and as a general guideline it is recommended to take Rosuvast around the same time every day.

Follow the instructions of your physician carefully in terms of dosage, in terms of adherence to the diet or other instructions recommended by the your physician. Also, you should not take a dose more or less than that prescribed by your doctor.

Usually, the doctor will prescribe a low dose of Rosuvast at the beginning of the treatment and then gradually increase the dose. Usually the doctor increases the dose (if needed) once every 4 weeks. You should continue to take Rosuvast even if you feel better, and do not stop taking Rosuvast without talking to your doctor.

What you should know about Rosuvast

Usually, your doctor will ask for some lab. tests  that measure liver function, and based on the results of these tests, the doctor will decide whether or not to use Rosuvast, and you must tell your doctor if you are currently or have ever suffered from liver-related diseases.

Some medical conditions warrant caution when taking Rosuvast, so you should tell your doctor if you have or have ever had any of the following conditions and conditions:

  • You drink alcoholic beverages.
  • If you are over 65 years old.
  • Patients of Asian descent, particularly Chinese, are more susceptible to the side effects of Rosuvast.
  • A decrease in the activity of the thyroid gland.
  • Diabetes .
  • Epilepsy.
  • Muscle pain or weakness.
  • Reduction of Blood pressure.
  • Kidney disease.
  • Liver diseases.

Rosuvast is not suitable for pregnant or breastfeeding women

Tell your doctor if you are pregnant or planning to become pregnant. You should not become pregnant during treatment with Rosuvast, and you should talk to your doctor about contraceptives that can be used during treatment with Rosuvast.

If you become pregnant during treatment with Rosuvast, you should stop taking Rosuvast and contact your doctor as soon as possible, as the use of Rosuvast during pregnancy can harm the unborn baby.

Tell your doctor if you are breast-feeding a baby. Breast-feeding should not be continued during treatment with Rosuvast.

Rosuvast may affect blood clotting

If you are going to have surgery, including dental surgery, you should tell your doctor or dentist that you are taking Rosuvast.

If you are hospitalized due to an accident or a serious infection, you must tell the doctors who are treating you that you are taking Rosuvast.

Life modification along with Rosuvast

  • drink less alcohol: Consumption of alcoholic beverages may increase the possibility and risk of side effects as a result of the use of Rosuvast.
  • Make sure to eat low-fat food, and stick to a low-cholesterol diet.
  • Be sure to follow all exercise and nutritional recommendations provided by your doctor or dietitian.
  • Tell your doctor about all other medicines you are taking before he prescribes Rosuvast
  • Before taking Rosuvast, tell your doctor or pharmacist if you are allergic to it, any other drugs (statins), or any of the ingredients in Rosuvast. Ask your doctor or pharmacist for a list of ingredients.

Before taking Rosuvast, tell your doctor if you are taking any of the following medicines.

  • Antifungal medications such as itraconazole (Sporanox) and ketoconazole (Nizoral).
  • Some antibiotics such as clarithromycin (klacid), and erythromycin.
  • Medicines containing cobicistat, cyclosporine or danazol.
  • protease inhibitors, to treat HIV such as atazanavir, indinavir, benavir, nelfinavir, ritonavir, saquinavir; nefazodone;

Be sure to tell your doctor about all the medicines you are taking, especially those on the following list:

  • Amiodarone (Cordarone), a heart pacemaker, is used in other conditions related to the heart and blood circulation.
  • Amlodipine (Norvasc), a treatment for high blood pressure and other conditions related to the heart and circulation.
  • Warfarin (Coumadin) is a blood thinner (an anticoagulant).
  • Colchicine (colmetidine) is a treatment for gout.
  • Digoxin (Lanoxin) is used to treat heart failure or heart failure.
  • Diltiazem, is a treatment for lowering blood pressure and other conditions related to the heart and circulation.
  • Other cholesterol-lowering medicines such as fenofibrate (Lipanthyl) or niacin.
  • Verapamil, a treatment for conditions related to the heart and blood circulation.

In general, you should tell your doctor about all the medicines you are taking, even if they do not appear on the previous list.

Rosuvastatin - pharmacology
Rosuvastatin – pharmacology

Side Effects

Rosuvast may cause the followin side effects. You should tell your doctor if any of these symptoms increase, worsen or persist for a long time:

  • constipation
  • stomachache
  • nausea
  • a headache
  • Memory loss or forgetfulness
  • Confusion and lack of concentration.

Some side effects may be serious. If you experience any of the following symptoms, contact your doctor immediately or as soon as possible:

  • Muscle pain or weakness.
  • dark urine
  • Decreased frequency of urination
  • Lack of energy, tiredness, or weakness
  • Anorexia
  • Pain in the upper right part of the stomach
  • Yellowing of the skin or eyes
  • fever or chills
  • rash, or itching.
  • Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • Difficulty breathing or swallowing.
  • Hoarseness.
  • Arthritis.
  • photosensitivity;

Rosuvast – Frequently Asked Questions

Q: Can I stop cholesterol medication?

Patients who stop taking cholesterol-lowering drugs, called statins, can pose a long-term risk. Researchers have found that patients who stop taking cholesterol drugs because they experience side effects such as muscle aches or stomach pain are more likely to die, or  had a heart attack or stroke by 13 percent compared to those who continued to take the drug.

Despite the overwhelming evidence of the importance of cholesterol-lowering drugs, between 25% and 50% of patients stop taking lipid-lowering drugs within 6 months to a year.

Q: Am I going to take cholesterol medicine for life?

If you have high blood fats, and you’ve tried diet and exercise and these methods haven’t reduced your blood fats, your doctor will prescribe a blood fat lowering medication, such as Rosuvast, for three months, then re-measure your blood fat levels. If you test results are within normal range, your doctor will advise you to stop with the need to maintain a moderate diet in fat content, and exercise.

There is a hereditary condition called “familial hypercholesterolemia”, in which the body cannot get rid of cholesterol naturally. Patients with this condition must use cholesterol medications for life.

Q: Does cholesterol medication cause weight loss?

Cholesterol treatment drugs reduce fat levels in the blood, but they do not contribute to weight loss, and have nothing to do with stored or accumulated fats in the body.

But usually a patient with high cholesterol in the blood is advised to exercise, and eat a healthy balanced diet along with cholesterol treatment medications, and these tips contribute in some way to weight loss, and therefore some people may think that weight loss occurred due to Cholesterol treatments, but this belief is incorrect.

Q: What is the best time to take cholesterol pills?

Cholesterol medications are usually prescribed once daily in the evening, or as directed by your doctor. However, the dose can be taken at any time of the day, either with or without food.

The dose and concentration of cholesterol medications are determined based on the patient’s condition – the dose varies from person to person depending on cholesterol levels in the blood, so it is important to follow the instructions given by the doctor.

Usually, the doctor prescribes a low dose at the beginning of the treatment and then gradually increases the dose. A diet low in fat content must be adhered to during treatment with cholesterol medications.

If you miss a dose.. Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose, and then continue to your regular schedule. And do not take a double dose to make up for a forgotten dose.

Q: What are the side effects of cholesterol medications?

Among the most famous medicines that are used in the treatment of high blood fats, a class of medicines called statins, which is the category to which Rosuvast, Lipitor, Zocor, and Lysicol belong… Despite the benefits of these medicines in lowering blood cholesterol, they have a group of Negative effects that may increase to the point that prompt the patient to stop taking the drug.

Constipation, stomach pain, nausea, headache, memory loss or forgetfulness, confusion and lack of concentration are the most common side effects of cholesterol medicines from the class of statins.

muscle pain or weakness, dark urine, decreased frequency of urination, lack of energy, tiredness, or weakness, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes,  unexplained fever or chills, Joint pain, sensitivity to light…all of the possible negative effects that may occur as a result of the use of statin-type blood fat drugs.

Q: What is the best medicine for cholesterol?

The best medicine for cholesterol differs from one patient to another. The type of  medicine is determined by the patient’s own reaction to the medicine. The doctor may prescribe a cholesterol medicine for you, and after a while he will prescribe another medicine for you, because the results of the patient’s blood lipids analysis were not good, or because the patient suffered from severe side effects that necessitated changing the medicine.

Therefore, the best medicine for cholesterol determines by the reaction of the patient itself, and therefore the best medicine differs from one patient to another. But the best medicine for cholesterol actually is to follow your doctor’s medication instructions carefully, follow the diet that your doctor specified for you, in addition to exercising regularly and reducing or quitting smoking or alcohol. Tags: C10BA06


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