Rofenac Suppositories: Your Comprehensive Guide to Relief

Composition

Rofenac Suppositories contain Diclofenac Sodium, a nonsteroidal compound with powerful antirheumatic, anti-inflammatory, analgesic, and antipyretic properties. These suppositories come in various strengths: 12.5 mg, 25 mg, 50 mg, and 100 mg.

What Rofenac Does

Rofenac inhibits prostaglandin biosynthesis, a key player in causing inflammation, pain, and fever. It’s indicated for conditions such as:

  • Rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis
  • Non-articular rheumatism
  • Acute musculoskeletal disorders, back pain, and painful syndromes of the vertebral column
  • Relief of pain in acute trauma and fractures
  • Control of pain and inflammation in orthopedic, dental, and other surgeries
  • Painful inflammatory conditions in gynecology and primary dysmenorrhea
  • Renal colic and biliary colic (Rofenac ampoules recommended)
  • Acute attacks of gout

Dosage and Administration

  • Adults: Initial daily dose is usually 100-150 mg. For milder cases or prolonged therapy, 75-100 mg daily may be sufficient. The daily dosage is generally given in 2-3 divided doses. In primary dysmenorrhea, the dosage is generally 50-150 mg.
  • Children: Children from the age of 1 year upwards should be given 0.5-2 mg/kg body weight daily, in 2-3 divided doses. Rofenac should not be given to children under 12 months of age.

When Not to Use Rofenac

  • Hypersensitivity to Diclofenac.
  • Avoid in patients with peptic ulcer and those in whom aspirin induces asthma, acute rhinitis, and urticaria.

Precautions

  • Use with caution in patients with severe impairment of hepatic function.
  • Exercise caution in cases of impaired cardiac or renal function, in patients being treated with diuretics, and in those recovering from major surgical operations.
  • Like other nonsteroidal anti-inflammatory drugs, Rofenac may trigger allergic reactions, including anaphylaxis.
  • Use during pregnancy only if benefits to the mother justify potential risks to the fetus.

Special Warnings

  • Cardiovascular Risk: NSAIDs may cause an increased risk of serious cardiovascular thrombotic events. Diclofenac is contraindicated for peri-operative pain in coronary artery bypass graft (CABG) surgery.
  • Gastrointestinal Risks: NSAIDs increase the risk of serious gastrointestinal adverse events, especially in elderly patients.

Side Effects

Rofenac is generally well-tolerated. Common side effects include gastrointestinal disturbances, headache, and dizziness. Fluid retention, liver function disorders, rash, and pruritus have been reported.

Interactions

  • NSAIDs may inhibit the activity of diuretics.
  • Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.
  • Patients taking Diclofenac and also receiving Digoxin, Methotrexate, Cyclosporine, or Lithium should be observed for potential specific toxicities.

Storage

Store between 15-30°C. Suppositories are available in 12.5 mg, 25 mg, 50 mg, and 100 mg.

Important Note

This information was last revised in March 2007. Always follow your doctor’s prescription, method of use, and instructions from the pharmacist. Keep medications out of the reach of children.