Quadriderm Cream

QUADRIDERM Cream is indicated for the relief of the inflammatory manifestations of corticosteroid-responsive dermatoses when complicated by secondary infection caused by organisms sensitive to the components of this dermatologic preparation or when the possibility of such infection is suspected.

Such disorders include: inguinal dermatosis, chronic dermatitis of the extremities, erythrasma, balanoposthitis, herpes zoster, eczematiod dermatitis,contact dermatitis, follicular dermatitis, dyshidrosis, paronychia, anal pruritus, seborrheic eczema, intertrigo, seborrheic dermatitis, pustular acne, impetigo, neurodermatitis, angular stomatitis, photosensitivity dermatitis, lichenified inguinal dermatophytosis and tinea infections such as tinea pedis, tinea cruris and tinea corporis.

Dosage And Administration

A thin film of QUADRIDERM Cream should be applied to cover completely the affected area two or three times daily, or as prescribed by the physician.

Frequency of application should be determined according to severity of the condition. Duration of therapy should be determined by patient response. In cases of tinea pedis, longer therapy (2-4 weeks) may be necessary.


Quadriderm– cream is a Brand of betamethasone valerate, gentamicin sulfate, tolnaftate and clioquinol For Dermatologic Use Only.

Each gram of QUADRIDERM Cream contains betamethasone valerate equivalent to 0.5 mg betamethasone, gentamicin sulfate equivalent to 1.0 mg gentamicin, 10 mg tolnaftate and 10 mg clioquinol (iodochlorhydroxyquin) in a paraben- and lanolin-free water washable cream base containing 0.1% chlorocresol as a preservative.

The cream base is composed of: chlorocresol, monocetyl ether of polyethylene glycol, white petrolatum, sodium phosphate, and purified water.


QUADRIDERM Cream combines the anti-inflammatory, antipruritic and vasoconstrictive agent betamethasone valerate, the wide-spectrum antibiotic gentamicin sulfate, the fungicidal agent tolnaftate and clioquinol, an antibacterial and antifungal agent.

Adverse Reactions

Local adverse reactions reported with the use of topical corticosteroids, especially under occlusive dressings, include: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, stria and miliarie.

Rash, irritation and hypersensitivity have been reported with the topical usage of gentamicin sulfate, clioquinol and rarely with tolnafate.


QUADRIDERM Cream is contraindicated in those patients with a history of sensitivity reactions to any of its components.


Any of the side effects that are reported following systemic use of corticosteroids, including adrenal suppression, may also occur with topical corticosteroids, especially in infants and children.

Systemic absorption of topical corticosteroids will be increased if extensive body surface areas are treated or if the occlusive technique is used. Suitable precautions should be taken under these conditions or when long-term use is anticipated, particularly in infants and children.

Systemic absorption of topically applied gentamicin may be increased if extensive body surface areas are treated, especially over prolonged time periods or in the presence of dermal disruption.

In these cases, the undesirable effects which occur following systemic use of gentamicin may potentially occur. Cautious use is recommended under these conditions, particularly in infants and children.

Quadriderm Cream- Patient Information Leaflet