Prostasin [Terazosin] Oral tablets: Benefits, Risks & FAQs

Prostasin is a brand name for the medication terazosin, which belongs to the class of drugs called alpha-1 blockers. It is primarily used to treat hypertension (high blood pressure) and benign prostatic hyperplasia (BPH), a condition where the prostate gland enlarges and causes urinary problems in men.

Prostasin works by relaxing the muscles in the blood vessels and prostate gland, allowing for improved blood flow and easier urination. It is usually taken orally Once daily, night time.

Indications

• Prostasin used alone or in combination with other antihypertensive for the treatment of hypertension.
• Prostasin single therapy is also used to relieve the signs and symptoms of benign prostatic hyperplasia (BPH).

Prostasin is available in 2 concentrations:

• Prostasin 2 mg oral tablets.
• Prostasin 5 mg oral tablets.

Dosage  & related FAQs

The dose of Prostasin should be adjusted according to the patient’s individual response. The following is a guide to its administration:

The recommended starting dose for all patients is 1 mg at bedtime. This dose should not be exceeded. This initial dosing regimen should be strictly observed to minimize the potential for severe hypotensive effects.

• For hypertension, the usual starting dose is 1 mg once daily at bedtime, which can be gradually increased to a maximum of 10 mg per day.
• For BPH, the usual starting dose is 1 mg once daily at bedtime, which can be gradually increased to a maximum of 20 mg per day.

If Prostasin administration is discontinued for several days or longer, therapy should be reinstituted using the initial dosing regimen.

Best time to take Prostasin pills

Prostasin is usually taken once daily at bedtime. This is because it can cause dizziness and fainting, and taking it at night can help to minimize these side effects.

Does the Prostasin dosage taken before or after food?

Prostasin can be taken with or without food, but it is generally recommended to take it on an empty stomach. This is because taking it with food can reduce its absorption and effectiveness.

N.B. Food had little or no effect on the bioavailability of Terazosin hydrochloride administered in a oral formulation.

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Side effects

Common side effects of Prostasin include dizziness, lightheadedness, headache, fatigue, and nausea. More serious side effects can include fainting, rapid heartbeat, chest pain, and difficulty breathing. For full list of side effects, you can visit: https://pharmacily.com/Prostasin-terazosin-hydrochloride/

Here is a list of possible side effects , that may occur while taking Prostasin

Asthenia (physical weakness or lack of energy) Headache Palpitation Postural Hypotension Syncope

Back Pain Nausea weight gain dissiness libido decrease dyspnea nasal congestion

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Precautions and warnings

Prostasin can cause dizziness, lightheadedness, and fainting, especially when standing up from a sitting or lying position. Patients should avoid driving or operating heavy machinery until they know how the medication affects them.

Prostasin should be used with caution in patients with liver or kidney disease, and in patients taking other medications that lower blood pressure.

Find out more information about Precautions & Warnings, from the following link: https://pharmacily.com/Prostasin-terazosin-hydrochloride/

1.Cataract surgery Precaution

Patients taking Terazosin (Prostasin)  should inform their ophthalmologist about their medication use before undergoing cataract surgery. This is because Terazosin (Prostasin) may cause intraoperative floppy iris syndrome (IFIS), a condition that can cause complications during cataract surgery. Therefore, the surgeon may need to modify the surgical technique to prevent or manage this complication.

2.Can Prostasin be taken during pregnancy & breastfeeding?

Prostasin is not recommended for use during pregnancy or breastfeeding. Terazosin hydrochloride (Prostasin) is not recommended during pregnancy unless the potential benefit justifies the potential risk to the mother and fetus.

It is not known whether terazosin hydrochloride (Prostasin) is excreted in breast milk. Because many drugs are excreted in breast milk, caution should be exercised when terazosin hydrochloride is administered to a nursing woman.

3.Does Prostasin suitable for children?

Prostasin is not recommended for use in pediatric patients or children.

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Prostasin – Topics related to men health

1.Effect of Prostasin on Erection

Terazosin may cause a decrease in sexual function, including erectile dysfunction. This is because the drug works by relaxing the smooth muscles in the prostate and bladder neck, but it can also affect the smooth muscles in the blood vessels of the penis. However, this side effect is not common and usually reversible after discontinuing the medication.

2.Interaction between terazosin and sildenafil (Viagra)

Sildenafil, a PDE-5 inhibitor, is commonly used for the treatment of erectile dysfunction. When taken together with Terazosin (Prostasin), it can cause a sudden drop in blood pressure, leading to dizziness, fainting, or even heart attack or stroke. Therefore, these two drugs should not be taken together without the advice of a healthcare professional.

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Prostasin & Other BPH medications

Medicines for BPH

Common medications for BPH include :

1. Alpha-blockers (such as tamsulosin and doxazosin),
2. 5-alpha-reductase inhibitors (such as finasteride and dutasteride),
3. and combination medications (such as Jalyn, which contains dutasteride and tamsulosin).

1.Difference between Prostasin & Cardura

Terazocin (Prostasin) and Cardura (Doxazosin) are both alpha-1 adrenergic receptor blockers used in the treatment of hypertension and benign prostatic hyperplasia (BPH). While they belong to the same class of drugs, there are some differences between them:

1. Dosage: The recommended starting dose of terazosin (Prostasin) for hypertension is 1 mg, while for Doxazosin (Cardura) it is 1 mg or 2 mg. For BPH, the starting dose of terazosin (Prostasin) is also 1 mg, and for doxazosin (Cardura), it is 4 mg.
2. Half-life: Terazosin has a shorter half-life of around 12 hours compared to doxazosin, which has a longer half-life of around 22 hours. This means that terazosin (Prostasin) may need to be taken more frequently than doxazosin (Cardura).
3. Food interactions: doxazosin (Cardura) should be taken with food, as it is more effective when taken with a meal, while terazosin (Prostasin) can be taken with or without food.
4. Indications: Both drugs are indicated for the treatment of hypertension and BPH. However, doxazosin (Cardura) is also approved for the treatment of urinary retention associated with BPH.

It is important to note that both drugs can cause dizziness, fainting, and orthostatic hypotension, which may be more pronounced with the initial dose or when increasing the dose. Therefore, caution should be exercised when driving or operating heavy machinery, and patients should be advised to change positions slowly to minimize these side effects.

2.Difference between Prostasin & Xatral

Terazocin and alfuzosin are both alpha-blockers used to treat BPH. However, terazocin is generally considered to be more selective for the alpha-1 receptor subtype than alfuzosin. This may result in fewer side effects with terazocin, particularly in terms of orthostatic hypotension.

While both medicines belong to the same drug class, there are some differences between them:

1. Dosage: Terazosin (Prostasin) is usually started at a low dose and gradually increased over time, while alfuzosin (Xatral) is typically started at a higher dose and does not require titration.
2. Administration: Terazosin (Prostasin) should be taken with or after a meal, while alfuzosin (Xatral) should be taken on an empty stomach or with food. This is because food can affect the absorption of these drugs.
3. Duration of action: Terazosin (Prostasin) has a shorter half-life compared to alfuzosin, meaning it requires more frequent dosing. Alfuzosin (Xatral), on the other hand, has a longer half-life and is typically taken once daily.
4. Side effects: Both drugs can cause dizziness, lightheadedness, and low blood pressure. However, Terazosin (Prostasin) may be associated with a higher risk of these side effects due to its shorter half-life.
5. Interactions: Terazosin (Prostasin) may interact with other drugs that lower blood pressure, while alfuzosin (Xatral) is less likely to have such interactions.

Overall, both drugs are effective in the treatment of BPH, but their dosing, administration, and side effect profiles differ slightly. Your doctor will help you decide which medication is best for you based on your individual needs and medical history.

3.Difference between Prostasin & Omnic

Terazosin (sold as, Prostasin) and tamsulosin (sold as, Omnic) are both used for the treatment of BPH, but they belong to different classes of drugs.

• Terazosin is an alpha-blocker that works by relaxing the smooth muscles in the prostate and bladder neck,
• while tamsulosin is a selective alpha-1a receptor antagonist that has a more specific action on the prostate.

There are some differences between the two medications:

1. Mechanism of action: Terazosin (Prostasin) is an alpha-1 blocker that works by relaxing the smooth muscle in the prostate and bladder neck. Tamsulosin (Omnic) is a selective alpha-1a blocker that also relaxes the smooth muscle in the prostate and bladder neck, but with more specificity to the prostate gland.
2. Dosage: Terazosin is usually taken once daily, while Tamsulosin is usually taken once daily as well but should be taken 30 minutes after the same meal every day.
3. Side effects: Both medications can cause similar side effects, such as dizziness, headache, and low blood pressure. However, Tamsulosin has a lower risk of causing orthostatic hypotension (a sudden drop in blood pressure when standing up) compared to Terazosin.
4. Effectiveness: Both medications are effective in improving urinary symptoms in men with BPH. However, some studies have suggested that Tamsulosin may be slightly more effective than Terazosin in reducing symptoms such as urinary frequency, urgency, and incomplete bladder emptying.

It is important to note that the choice between Terazosin and Tamsulosin should be based on individual patient factors, such as their medical history, other medications they may be taking, and the severity of their symptoms.

Tamsulosin (Omnic) is generally preferred over terazosin (Prostasin) because it has fewer side effects and is better tolerated. Tamsulosin is also considered to be more effective in improving symptoms of BPH such as urinary flow rate and frequency of urination.

4.Difference between Prostasin & Avodart

Prostasin (terazosin) and Avodart (dutasteride) are two different medications used to treat different conditions:

• Prostasin (terazosin) belongs to a class of drugs called alpha-blockers and is primarily used to treat hypertension (high blood pressure) and benign prostatic hyperplasia (BPH) in men. It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.
• Avodart (dutasteride) belongs to a class of drugs called 5-alpha-reductase inhibitors and is primarily used to treat BPH in men. It works by reducing the size of the prostate gland by blocking the conversion of testosterone to dihydrotestosterone (DHT), a hormone that promotes the growth of the prostate gland.

Some differences between Prostasin and Avodart include:

• Mechanism of action: Prostasin works by relaxing the muscles in the prostate and bladder neck, while Avodart works by reducing the size of the prostate gland by blocking the conversion of testosterone to DHT.
• Indications: Prostasin is indicated for the treatment of hypertension and BPH, while Avodart is indicated only for the treatment of BPH.
• Dosage forms: Prostasin is available in immediate-release tablets, while Avodart is available in soft gelatin tablets.
• Dosage frequency: Prostasin is usually taken once daily, while Avodart is usually taken once daily as well.
• Side effects: The side effects of Prostasin may include dizziness, headache, nausea, fatigue, and low blood pressure, while the side effects of Avodart may include decreased libido, erectile dysfunction, breast tenderness or enlargement, and ejaculation disorders.

It is important to note that both medications can interact with other drugs and may not be suitable for everyone. Therefore, it is essential to consult with a healthcare professional before taking any medication.

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ATC CODE: G04CA03 . *Manufactured by: Pharco Pharmaceuticals.