Ponstan Forte 500 mg film-coated tablet

Trade Name: Ponstan Forte 500 mg film-coated tablet
Scientific Name: Mefenamic Acid
Strength: 500 mg
Dosage Form: Film-coated tablet
Route of Administration: Oral use

Indications: Ponstan Forte is used to treat various types of pain, including acute and chronic pain. It is particularly effective for pain associated with rheumatic diseases, muscle pain, spinal column conditions, post-operative pain, pain following injuries, headaches, toothaches, earaches, primary dysmenorrhea, and hypermenorrhea caused by intrauterine devices (IUDs) when organic pelvic pathology is excluded. It can also be used to relieve pain and reduce fever in flu-like illnesses and other infectious diseases associated with fever, especially those localized in the upper respiratory tract.

Dosage and Administration:

  • The recommended dosage for adults and children over 14 years is one Ponstan Forte tablet (500 mg) taken three times a day with food. The dosage can be adjusted based on individual needs, but the daily dosage should not exceed 2.0 grams (equivalent to four tablets).

Special Dosage Instructions for Children and Adolescents:

  • Children should only receive mefenamic acid for short-term treatment unless they are being treated for Still’s disease.

Contraindications: Do not use Ponstan Forte if you have:

  • Hypersensitivity to mefenamic acid or any of the excipients.
  • A history of bronchospasm, urticaria, or allergy-like symptoms after taking acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs).
  • Reached the third trimester of pregnancy or are in the lactation period.
  • Active peptic or duodenal ulcers or gastrointestinal bleeding.
  • Inflammatory bowel diseases like Crohn’s disease or ulcerative colitis.
  • Severe hepatic impairment (cirrhosis of the liver and ascites).
  • Severe renal impairment (creatinine clearance less than 30 ml/min).
  • Severe congestive heart failure (NYHA III-IV).
  • Postoperative pain following coronary bypass surgery (or use of a heart-lung machine).

Warnings and Precautions: Ponstan Forte should be used with caution in individuals at risk of gastrointestinal effects, cardiovascular effects, renal effects, skin reactions, and hematological effects. Special care is needed for patients with certain conditions or using specific medications, such as diuretics, anticoagulants, corticosteroids, or selective serotonin reuptake inhibitors. Patients with known cardiovascular or renal diseases are at greater risk.

Interactions: Ponstan Forte may interact with medications like acetylsalicylic acid, hypoglycemic agents, anticoagulants, anti-hypertensives, cyclosporine, corticosteroids, lithium, methotrexate, selective serotonin reuptake inhibitors (SSRIs), and tacrolimus. Consult with a healthcare provider when using these medications concurrently.

Pregnancy and Lactation:

  • Ponstan Forte should only be used during the first and second trimester of pregnancy when absolutely necessary. It’s contraindicated in the third trimester.
  • Nursing mothers should not use Ponstan Forte, as mefenamic acid passes into breast milk.

Side Effects: Common side effects include diarrhea, abdominal pain, nausea, and vomiting. Less common side effects involve various systems, including blood, immune, metabolism, nervous, eye, ear, cardiac, vascular, respiratory, gastrointestinal, hepatic, skin, renal, and general disorders. These side effects can range from blood count changes to gastrointestinal ulcerations, cardiovascular effects, renal effects, skin reactions, and more.

Overdose: An overdose may result in convulsions, muscle twitching, acute renal failure, and coma. Immediate medical attention is necessary.

Pharmacological Properties: Ponstan Forte contains mefenamic acid, a non-steroidal anti-inflammatory drug (NSAID). It inhibits prostaglandin synthesis, leading to its anti-inflammatory, analgesic, and antipyretic effects.

Excipients: Inactive ingredients in the film-coated tablet include cellulose microcrystalline, maize starch, methylcellulose, sodium lauryl sulfate, colloidal silica, magnesium stearate, talcum, hypromellose, polyethylene glycol 6000, and colorants.

This information is based on the provided product description and should be reviewed with a healthcare provider or the medication’s packaging and instructions for the most accurate and up-to-date information.