Nu-Spasm: A Comprehensive Guide to Usage and Benefits

Nu-Spasm, available in film-coated tablets, ampoules, and syrup, is a medication primarily composed of Hyoscine-N-butylbromide. This article aims to provide a detailed guide on Nu-Spasm, explaining its composition, mechanisms of action, indications, dosage recommendations, precautions, side effects, and practical tips for users.

Composition and Positive Impact

Nu-Spasm contains Hyoscine-N-butylbromide, a synthetic quaternary ammonium derivative structurally related to belladonna alkaloids. This compound specifically targets smooth muscles in the gastrointestinal, biliary, and urinary tracts, making it effective in conditions associated with visceral spasms or renal colic.

Mechanisms of Action

Hyoscine-N-butylbromide is poorly absorbed from the gastrointestinal tract, and it does not readily pass through the blood-brain barrier. This unique pharmacokinetic profile allows it to exert its antispasmodic effects locally on smooth muscles without causing central effects, making central side effects rare.

Indications and Dosage

Nu-Spasm is indicated for various conditions related to spasms:

  • Gastrointestinal spasm and hypermotility.
  • Spastic disorders of the biliary tract.
  • Spastic disorders of the urinary tract.
  • Dysmenorrhoea.
  • Gastric and duodenal ulcers.


  • Adults: 1-2 tablets 3-4 times daily or one ampoule IM or IV, repeated if necessary.
  • Children: 1-2 teaspoonfuls 3 times daily.

Common Side Effects and Precautions

Nu-Spasm, due to its limited central effects, has rare central side effects. However, certain precautions should be observed:

  • Hepatic and Renal Dysfunction: Use Nu-Spasm cautiously in individuals with hepatic and renal dysfunction.

Pregnancy and Lactation

Nu-Spasm is not recommended during pregnancy and lactation. Consultation with a healthcare professional is crucial in such situations.

Dealing with Side Effects

Given Nu-Spasm’s unique pharmacokinetics, central side effects are rare. However, users may encounter some side effects. Here are practical tips:

  1. Central Effects: Since central effects are rare, users can generally expect a well-tolerated medication.
  2. Hypersensitivity: Individuals with hypersensitivity to the product or belladonna alkaloids should avoid Nu-Spasm.

Storage and Availability

Nu-Spasm is available in various forms:

  • Film-coated tablets: Blisters of 10 tablets each.
  • Ampoules: Box of 3 ampoules; each of 1 ml.
  • Syrup: Bottle of 125 ml.

It should be stored at a temperature not exceeding 30°C, away from light.


Nu-Spasm, with its focus on antispasmodic effects in the gastrointestinal, biliary, and urinary tracts, provides a valuable therapeutic option for conditions involving spasms. Understanding its composition, mechanisms of action, proper usage, and potential precautions ensures optimal and safe utilization. As with any medication, it is crucial to follow healthcare professionals’ guidance, especially considering individual health conditions. Always consult with a healthcare provider for personalized advice and to address any specific concerns related to Nu-Spasm.