Navigating ZYTIGA®: A Comprehensive Guide to Administration and Precautions

ZYTIGA® (abiraterone acetate) is a prescription medication used in conjunction with prednisone to treat men with metastatic prostate cancer, a condition where prostate cancer has spread to other parts of the body. ZYTIGA® belongs to a class of drugs called androgen biosynthesis inhibitors (ABIs), which work by blocking the production of androgens, hormones that play a crucial role in the growth and progression of prostate cancer.

Adherence to Treatment Instructions

The success of ZYTIGA® therapy hinges on strict adherence to the prescribed dosage and administration schedule. It is crucial to follow your healthcare provider’s instructions carefully to ensure optimal effectiveness and minimize the risk of side effects.

Dosage and Administration

ZYTIGA® is typically administered as a single oral dosage, taken once daily on an empty stomach. Avoid consuming food within two hours before and one hour after taking ZYTIGA®, as this can increase drug absorption and potentially lead to adverse reactions. Swallow the tablet whole with water, avoiding crushing or chewing it.

Prednisone Coadministration

ZYTIGA® is always prescribed in combination with prednisone, a corticosteroid that helps manage potential side effects associated with ZYTIGA® treatment. It is essential to adhere to the prescribed prednisone dosage and schedule as instructed by your healthcare provider.

Precautions and Interactions

Medication Interactions

ZYTIGA® can interact with certain medications, potentially affecting their effectiveness or increasing the risk of side effects. Inform your healthcare provider and pharmacist about all medications, supplements, and herbal remedies you are taking to avoid potential interactions.

Missed Doses

In the event of a missed ZYTIGA® or prednisone dose, take the prescribed dose as soon as you remember the following day. If more than one dose is missed, contact your healthcare provider immediately for further guidance.

Maintaining Treatment Adherence

Adherence to the prescribed treatment regimen is crucial for maximizing the benefits of ZYTIGA® therapy. Here are some tips to help you stay on track:

  1. Develop a Routine: Establish a consistent schedule for taking ZYTIGA® and prednisone, incorporating them into your daily routine.
  2. Use Reminders: Set alarms or reminders on your phone or calendar to alert you when it’s time to take your medications.
  3. Plan Ahead: Anticipate upcoming trips or events and ensure you have a sufficient supply of ZYTIGA® and prednisone.
  4. Seek Support: Enlist the help of family or friends to remind you about your medications or help you manage refills.
  5. Utilize Online Tools: Enroll in Janssen CarePath, a patient support program that provides personalized medication reminders and refill assistance.
  6. Discuss Strategies: Consult with your healthcare provider to develop a medication management plan tailored to your needs and preferences.

Common Side Effects

ZYTIGA® is generally well-tolerated, but some side effects may occur, including:

  • Fatigue
  • Joint pain
  • Hypertension
  • Nausea
  • Edema (swelling) in legs or feet
  • Hypokalemia (low potassium levels)
  • Hot flashes
  • Diarrhea
  • Vomiting
  • Upper respiratory tract infections (cold, sinus infection, throat infection)
  • Cough
  • Headache
  • Anemia (low red blood cell count)
  • Hyperlipidemia (high cholesterol and triglycerides)
  • Hyperglycemia (high blood sugar)
  • Abnormal blood test results

Fertility Considerations

ZYTIGA® may potentially affect fertility in men, potentially impacting their ability to father children. Patients should discuss any concerns about fertility with their healthcare provider.


ZYTIGA® offers a valuable treatment option for men with metastatic prostate cancer, offering the potential to prolong survival, delay disease progression, and improve quality of life. Effective management of ZYTIGA® therapy requires close collaboration with a healthcare provider, strict adherence to the prescribed regimen, and proactive strategies to minimize side effects.