Isoptin 80 mg Tablets – Isoptin 240 mg Extended-Release Tablets

Isoptin is used in the treatment of hypertension, and secondary prevention after acute myocardial infarction. Verapamil hydrochloride is the active ingredient in Isoptin. It works by inhibiting the influx of calcium ions. It belongs to a class of drugs called calcium channel blockers or calcium antagonists.

Composition and availability

  • Isoptin 240 mg: Each film coated tablet contains verapamil hydrochloride 240 mg in an extended-release formulation.
  • Isoptin 80 mg: Each film coated tablet contains Verapamil Hydrochloride 80 mg.


Isoptin is indicated for the treatment of coronary artery disease (conditions characterized by an insufficient supply of oxygen to the heart muscle), including: chronic stable angina, unstable angina, and angina due to coronary constriction (“Prinzmetal’s” angina pectoris), Angina pectoris following myocardial infarction in patients without heart failure when there is no need for the use of beta-blockers.

Isoptin is also indicated for the treatment of arrhythmias in patients with episodes of supraventricular tachycardia, atrial fibrillation/atrial flutter with AV conduction tachycardia (except for Wolff-Parkinson-White syndrome or Lone-Ganong-Levine syndrome).

Isoptin is also used to treat high blood pressure.

Common side effects of Isoptin include: constipation, dizziness, rapid heartbeat (palpitations), fatigue, flushing and hot flashes in the face and chest area, headache, and swelling in the feet and legs.

Dosage and adminstration

The dose of Isoptin should be individually adjusted according to the severity of the disease. Long-term clinical experience shows that the average dose for all uses is between 240 mg and 360 mg, and the daily dose should not exceed 480 mg in the long term, although a higher dose may be used for a short period. There is no set limit for the period of use.

Do not stop taking Isoptin suddenly after long-term use. Rather, it is recommended to reduce the dose gradually.

For patients with impaired liver function, the metabolism of the drug may be delayed for a period that may increase or decrease depending on the extent of the liver dysfunction, resulting in an increase and prolongation of the effect of Isoptin; Therefore, the dose should be adjusted with caution in patients with impaired hepatic function, and lower doses should be given initially.

The tablets should be taken without chewing, drinking enough fluids, preferably with or shortly after meals.

Isoptin – FAQs

Is Isoptin cause sexual weakness in men? Yes, verapamil (the active ingredient in Isoptin) can cause a decrease in sex drive, decreased erectile strength and, in some cases, impotence.

Doctors’ opinions on the problem of ED: Verapamil (the active ingredient in Isoptin) rarely causes erectile dysfunction, but most patients with uncontrolled blood pressure (especially those who also suffer from diabetes) are more likely to develop sexual weakness as part of a complication of hypertension or Diabetes.

Is there a conflict between Isoptin and Viagra (Sildenafil)? There are no known drug interactions between verapamil (the active ingredient in Isoptin) and sildenafil (the generic name for Viagra). When they are taken together, each of the two drugs does not affect the other in any way.

What is Isoptin?  Isoptin belongs to a group of medicines known as calcium channel blockers. It is a drug that relaxes and widens the blood vessels, making it easier for blood to pass through the blood vessels. As a result, the heart does not have to work as hard to push the blood out. As the workload on the heart is reduced, it helps lower blood pressure and thus reduces the risk of heart attack and stroke.

What time of day should I take Isoptin?  Isoptin tablets should be taken at the same time each day. To reduce the chances of a missed dose, it should be taken at the dose and for the duration advised by the doctor. Your dose will depend on the condition for which you are being treated and, therefore, will vary from person to person. If you experience any side effects while taking Isoptin tablets, please consult your doctor.

I feel better after taking Isoptin, can I stop taking it?  No, keep taking Isoptin tablets even if you feel better and your blood pressure is under control. Stopping Isoptin tablets suddenly may increase your blood pressure and may increase your chances of having a stroke or heart attack. Usually once you start taking any blood pressure control medication, you must continue to take it for life unless you cannot tolerate it.

Will Isoptin make me dizzy? What should I do about it? Yes, Isoptin may make you feel dizzy or lightheaded. If Isoptin makes you dizzy when standing up, try getting up very slowly or staying seated until you feel better. If you start to feel dizzy, lie down so you don’t faint, and then sit down until you feel better. Do not drive, use tools or machines, and avoid any activity that requires concentration while you feel dizzy.

What other lifestyle changes should I make while taking Isoptin tablets? Lifestyle changes play a major role in maintaining your health, while taking Isoptin, it is advisable to:

  • Avoid having excess salt in your diet and find ways to reduce or control stress in your life.
  • Do yoga, meditate.
  • Make sure you get enough sleep every night as this also reduces your stress and thus helps keep your blood pressure normal.
  • Stop smoking and drinking alcohol, as this helps lower blood pressure and helps prevent heart problems.
  • Exercise regularly and eat a balanced diet that includes whole grains,  fresh fruits , Vegetables and fat-free products.

You should consult your doctor if you need further assistance to get the most benefit from Isoptin and to maintain your health.

Can Isoptin affect my fertility?  There is no evidence that Isoptin tablets have any effect on fertility in both men and women. However, if you are planning to become pregnant, talk to your doctor first because Isoptin is not recommended for use during pregnancy.

Precautionary tips

It is not known if it is safe for you to take alcohol with Isoptin.

Isoptin is not safe to use during pregnancy as there is clear evidence of risks to the developing baby. However, it is rarely prescribed by a doctor in certain life-threatening situations if the benefits outweigh the potential risks.

Isoptin is POSSIBLY UNSAFE for use while breast-feeding. Limited human data suggest that the drug may pass into breast milk and harm the baby.

Isoptin may reduce alertness, affect your vision, or make you drowsy and dizzy. Do not drive if these symptoms occur.

Isoptin should be used with caution in patients with severe kidney disease. A dose adjustment of Isoptin may be required. Isoptin is not recommended for use in patients with severe kidney disease.

Isoptin should be used with caution in patients with liver disease. The dose of Isoptin may need to be adjusted in this group of patients.

If you miss a dose of Isoptin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose to make up for a forgotten dose.

Calcium channel blockers

Calcium channel blockers are medicines used to lower blood pressure. They work by preventing calcium from entering the cells of the heart and arteries. Calcium causes the heart and arteries to contract (constrict) more forcefully. By blocking calcium, calcium channel blockers allow blood vessels to relax and open.

Calcium channel blockers can also slow the heart rate, which can lower blood pressure. These medications may also be prescribed to relieve chest pain (angina) and control an irregular heartbeat.

Calcium channel blockers are also called calcium antagonists.

Common side effects of calcium channel blockers include: constipation, dizziness, rapid heartbeat (palpitations), fatigue, flushing and hot flashes in the face and chest area, headache, and swelling in the feet and legs.

Grapefruit products should be avoided while taking some calcium channel blockers. Because grapefruit juice with medication and can affect heart rate and blood pressure. This can cause symptoms such as headache and dizziness.

What is Angina?

Angina is pain or discomfort (a feeling of pressure or squeezing) that occurs when the heart does not get enough oxygen (blood supply). Usually, a patient with angina feels pressure, pain, or soreness just below the chest bone, and sometimes pain can occur in the shoulder, arm, neck, jaw, or back. The symptoms of angina pectoris may be similar to the symptoms of indigestion.

Angina pectoris is not a disease, but rather a symptom of heart disease or ailment, and is usually the result of a disease in the coronary artery that supplies the heart with blood and oxygen (CAD). An angina attack occurs in coronary artery patients as a result of one or more of the following triggering factors:

  • Physical exertion, such as walking, climbing stairs, engaging in strenuous physical activity, or having sex.
  • Going out on a very hot or very cold day.
  • Eat a heavy meal.
  • Emotional stress or severe psychological crisis.
  • smoking.

Angina patients can be divided into two types:

Chronic stable angina pectoris: It results from a permanent and stable blockage in the coronary arteries feeding the heart muscle. It is also called stable angina pectoris or chronic stable angina pectoris.
Variable angina: It results from temporary narrowing, constriction or spasm of the coronary arteries supplying the heart. It is also called variable angina pectoris, Pranzimetl’s angina.

Why is Isoptin prescribed to patients with angina pectoris?

Cardiologists prescribe verapamil (the scientific name for Isoptin) for the prevention of chest pain caused by narrowing of the coronary arteries of the heart muscle (angina pectoris, also known as stable angina). Or in less frequent cases, such as chest pain resulting from severe contraction of the coronary arteries of the heart muscle (vasospastic angina, also known as Pranzimtel’s angina or variable angina).

If you suffer from angina pectoris (stable or variable), you should know that Isoptin improves the blood supply to the heart muscle, thus prevent chest pain (angina pain). It should be noted that verapamil does not relieve chest pain once it is used, but rather from continued use.

Isoptin is not prescribed to treat angina pain if it has already occurred, but it prevents its occurrence, therefore it is recommended to keep the doses of Isoptin that your doctor prescribed to you even if you feel well to avoid having an angina attack.

Isoptin is used as a first-line treatment in cases of coronary insufficiency, whether as a result of permanent obstruction (stable angina) or constriction of coronary arteries (Pranzimtel or variable angina) or both. Isoptin can also be used in cases of possible constriction of the coronary arteries. Isoptin may also be used alone or in combination with other anti-anginal medicines in patients who have not responded to nitrates and/or appropriate doses of beta-adrenergic blockers.

Isoptin is mainly used to treat myocardial ischemia when it is caused by a permanent blockage of the blood vessels in the myocardium, as in stable angina pectoris .

Isoptin can only be used as a stand-alone treatment or may be used in combination with other angina medications in patients who do not respond adequately to treatment with nitrates and/or beta-blockers.

What is supraventricular tachycardia?

Supraventricular tachycardia is a condition in which your heart suddenly beats much faster than usual. Supraventricular tachycardia is not usually serious, but some people may need treatment.

Supraventricular tachycardia occurs when the electrical system that controls your heart’s rhythm isn’t working properly.

This suddenly makes your heart beat faster. It can also slow down suddenly.

The normal resting heart rate is 60 to 100 beats per minute. But with supraventricular tachycardia, your heart rate suddenly rises above 100 beats per minute. This happened while resting or exercising.

Having supraventricular tachycardia means that your heart is suddenly beating faster. This tachycardia usually lasts a few minutes, but can sometimes last for several hours, and it can happen several times a day or once a year.

Supraventricular tachycardia can be caused by fatigue, caffeine, alcohol, or drugs — but there’s often no clear cause.

Supraventricular tachycardia can occur at any age, but most often it first begins in children and young adults – many people often have their first symptoms between 25 and 40 years of age.

People with supraventricular tachycardia may not have any other symptoms, but sometimes people may also feel:

  • pain in chest
  • Weakness, shortness of breath, or dizziness.
  • Unexplained fatigue.
  • Nausea , vomiting.

what is the high blood pressure?

High blood pressure, a medical condition known as (hypertension), it is also called (the silent killer). It is a condition mostly caused by narrowed arteries, which impede the easy flow of blood through the blood vessels. As a result, the heart is forced to pump blood more forcefully.

Over time, uncontrolled high blood pressure can damage arteries and other organs. This can lead to heart attack, heart failure, stroke, kidney disease, and other serious health consequences. High blood pressure is called the “silent killer,” because it has no symptoms. The only way to know if you have high blood pressure is to have your blood pressure checked by a doctor.

There is no cure for high blood pressure, however, there are several medications, including verapamil (Isoptin) that help control blood pressure. It’s important to note that eating a healthy diet, maintaining a healthy weight, not smoking, and being physically active can be just as important as taking medication. In most cases, cardiologists advise patients with high blood pressure to change their lifestyle.

Why Isoptin prescribed to patients with pressure?

If you suffer from high blood pressure, know that verapamil (the generic name for Isoptin) works by relaxing or widening the blood vessels, making blood pass through the blood vessels (arteries) easier.

Isoptin – PIL

You can read Isoptin Patient Information Leaflet (AR & EN) from the link here.

Isoptin - verapamil HCL
Isoptin – verapamil HCL

For Arabic information about Isoptin – click the link here.

Isoptin in Egypt

  • Manufactured by Kahira Pharma. & Chem.Ind.Co.
  • Market Authorization Holder in Egypt:  Abbott Laboratories GmbH – Freundallee 9A,30173 Hannover – Germany.
  • License Holder in Country of origin: Mylan Healthcare GmbH-Freundalleere 9A,30173 Hannover Germany.
  • For more information about Isoptin – click here (AR language).

Product reference code: C08DA01.