Epicoflocin: A Comprehensive Guide to Understanding Your Medication

Welcome to a detailed exploration of Epicoflocin, a medication designed to combat bacterial infections. In this comprehensive guide, we’ll break down the complexities of the original Patient Information Leaflet (PIL) to make it accessible to everyone. Our focus is on empowering patients with valuable information, ensuring they understand their medication thoroughly.

Understanding Epicoflocin


Epicoflocin contains the active ingredient Ofloxacin, a fluoroquinolone antibacterial. Each scored film-coated tablet is formulated with 200mg of Ofloxacin. This antibiotic is known for its broad spectrum of activity against various Gram-negative and Gram-positive bacteria.

How Epicoflocin Works

Ofloxacin, the powerhouse behind Epicoflocin, inhibits the DNA gyrase enzyme in bacteria, disrupting DNA replication. This mechanism of action makes it effective against a range of bacteria, including E. coli, Pseudomonas aeruginosa, Streptococcus, and more.

Indications: When to Use Epicoflocin

Epicoflocin is indicated for various infections, and the dosage and duration of treatment depend on the specific condition. Here’s a breakdown of its applications:

Urinary Tract Infections

  • Cystitis due to E. coli or K. pneumoniae:
    • Dosage: 200mg every 12 hours
    • Duration: 3 days
  • Cystitis due to other organisms:
    • Dosage: 200mg every 12 hours
    • Duration: 7 days
  • Complicated urinary tract infections:
    • Dosage: 200mg every 12 hours
    • Duration: 10 days

Lower Respiratory Tract Infections

  • Exacerbation of chronic bronchitis:
    • Dosage: 400mg every 12 hours
    • Duration: 10 days
  • Pneumonia:
    • Dosage: 400mg every 12 hours
    • Duration: 10 days

Skin and Skin Structure Infections

  • Dosage: 400mg every 12 hours
  • Duration: 10 days


  • Dosage: 300mg every 12 hours
  • Duration: 6 weeks

Sexually Transmitted Diseases

  • Uncomplicated gonorrhea:
    • Dosage: 400mg (single dose)
    • Duration: 1 day
  • Chlamydia and other infections:
    • Dosage: 300mg every 12 hours
    • Duration: 7 days

Renal Function Impairment

In patients with creatinine clearance values:

  • 50 ml/min or more: Use a 24-hour interval without adjusting the dosage.
  • 10–49 ml/min: Use a 24-hour interval and half the recommended dosage.

Positive Impact of Epicoflocin

Epicoflocin offers several advantages:

  1. Broad Spectrum: Effectively targets both Gram-negative and Gram-positive bacteria.
  2. Convenient Dosage: The medication allows for once-daily administration in most cases.
  3. High Bioavailability: Rapid absorption and wide distribution ensure effective treatment.

Dealing with Potential Side Effects

Understanding potential side effects is crucial for a safe medication experience. Common side effects may include:

  • Gastrointestinal Issues: Nausea, vomiting, abdominal pain, and diarrhea.
  • Central Nervous System and Skin Reactions: Dizziness, headache, insomnia, and skin rash.

Strategies for Managing Side Effects

  1. Take with Food: Epicoflocin tablets should be swallowed whole with a sufficient quantity of liquid and may be taken with meals to minimize gastrointestinal discomfort.
  2. Stay Hydrated: Ensure an adequate intake of fluids to prevent dehydration, especially if experiencing headaches.

Essential Precautions: Safeguarding Your Health

Before starting Epicoflocin, consider the following precautions:

  • Contraindications: Avoid if you have hypersensitivity to Ofloxacin, are under 18 years old, or pregnant.
  • Adverse Reactions: Be aware of potential adverse reactions, especially if you have renal or hepatic impairment, known CNS disorders, or sensitivity to sunlight.
  • Storage: Keep Epicoflocin below 30°C in a dry, cool place, out of reach of children.

Disease or Condition Information


  • Hypersensitivity: Excessive sensitivity to a particular substance.


  • Gastrointestinal Disorders: Pain or discomfort in the stomach, nausea, and abdominal pain.
  • Central Nervous System Issues: Dizziness and headaches.

Tips for Patients

  1. Nutritional Support: Maintain a well-balanced diet rich in nutrients to complement Epicoflocin treatment.
  2. Hydration: Ensure adequate fluid intake to prevent dehydration, especially if experiencing headaches.


Epicoflocin, with its active ingredient Ofloxacin, provides an effective solution for bacterial infections. By understanding its positive impacts, recommended dosage, potential side effects, and essential precautions, patients can approach their treatment confidently. Always consult healthcare professionals for personalized advice, and if you experience persistent side effects, seek immediate medical attention. This guide aims to simplify the medical information surrounding Epicoflocin, empowering patients to make informed decisions about their health.