Enhancing Patient Information: COLI – URINAL

Urinary tract infections can be challenging, but understanding your medication is a crucial step towards managing your health effectively. Let’s delve into the details of COLI – URINAL, shedding light on its composition, benefits, recommended usage, possible side effects, and essential precautions.

COLI – URINAL comes in the form of effervescent granules, offering a combination of urinary antiseptic and antispasmodic properties. This medication contains key components like Hexamine, Khellin, and Piperazine Hexahydrate, each contributing to its therapeutic effects.

Understanding the Composition

  • Hexamine (10gm): Acts as a potent antiseptic by slowly converting to formaldehyde and ammonia in acid urine.
  • Khellin (35mg): Provides direct relaxant action on smooth muscles, alleviating colic associated with urinary disorders.
  • Piperazine Hexahydrate (3gm, as citrate): Increases uric acid excretion and dissolves urate crystals.


COLI – URINAL is recommended for:

  • Various urinary tract infections such as pyelitis, pyelonephritis, cystitis, and urethritis.
  • Adjunct treatment for recurrent urate calculi.

Positive Impact of the Medicine

The antiseptic action of Hexamine, combined with the relaxant properties of Khellin, makes COLI – URINAL effective, especially in chronic cases where other antibacterials may fall short. Piperazine further enhances its benefits by aiding uric acid excretion.

Recommended Dosage

For optimal results, it is advisable to take COLI – URINAL after meals. The standard dosage is 1 tablespoonful in half a glass of water three times a day.

Common and Most Frequent Side Effects

While COLI – URINAL is generally well-tolerated, some patients may experience slight nausea, vomiting, or diarrhea. Overdoses, although rare, can lead to nervous complications, including somnolence, dizziness, and muscular incoordination, primarily due to Piperazine. Individuals with disturbances of renal function should be cautious.

Essential Precautions

  • Contraindications: Avoid in cases of impaired hepatic function due to the liberation of ammonia from Hexamine. Do not use in severe or moderate renal failure, severe dehydration, metabolic acidosis, neurological disturbances, or epilepsy.
  • Drug Interactions: Avoid combinations with Sulphathiazole (and other sulphonamides) to prevent the formation of insoluble urinary crystals with formaldehyde.

Urinary Tract Infections – Additional Information


Urinary Tract Infections (UTIs): Infections affecting any part of the urinary system, including the kidneys, bladder, and urethra.


  • Pain or burning during urination
  • Frequent urination
  • Cloudy or strong-smelling urine
  • Lower abdominal pain

Tips for Patients with UTIs

  • Stay hydrated
  • Avoid irritants like caffeine and alcohol
  • Complete the full course of antibiotics
  • Practice good hygiene

Dealing with Side Effects: Strategies for Managing Potential Side Effects

If you experience nausea or vomiting, taking COLI – URINAL with meals can help alleviate these symptoms. If side effects persist or worsen, consult your healthcare provider promptly.


Understanding your medication is vital for effective management. COLI – URINAL’s unique composition makes it a valuable option for urinary tract infections. Always follow your healthcare provider’s instructions and report any unusual reactions promptly. Keep COLI – URINAL in a cool, dry place, away from heat and light, and out of the reach of children.

By staying informed and proactive, you empower yourself in the journey towards better urinary health.