E-MOX is a Broad Spectrum Antibiotic.
Composition
| Each dosage unit contains | Capsules | Suspension (5ml) | Vial |
| Amoxicillin | 500 mg as trihydrate | 125 mg or 250 mg as trihydrate | 250 mg, 500 mg or 1 g as trihydrate |
Indications
Treatment of infections caused by susceptible bacteria, including:
- Upper respiratory tract infections: otitis media, sinusitis, tonsilitis, pharyngitis, and laryngitis.
- Lower respiratory tract infections: acute and chronic bronchitis, and pneumonia.
- Gastrointestinal tract infections: typhoid and paratyphoid fevers, biliary tract infections and gastroenteritis.
- Eradication of Helicobacter pylori.
- Genito-urinary tract infections.
- Skin and soft tissue infections.
- Prophylaxis of bacterial endocarditis.
Doses and Administration
Oral administration
- Adults: 500 mg every 8 hours.
- Children up to 10 years: 125 — 250 mg every 8 hours.
- Children under 40 kg body weight: 20 — 40 mg/kg daily in divided doses every 8 hours, or 25 — 45 mg/kg daily in divided doses every 12 hours.
Higher oral doses, either as a single dose or in short courses, may be used as follows:
- For dental abscesses: 3 gm repeated once after 8 hours.
- Uncomplicated acute urinary-tract infections: 3 gm repeated once after 10 — 12 hours.
- Severe or recurrent infections of respiratory tract: 3 gm twice daily.
- Children aged 3 — 10 years with otitis media: 750 mg twice daily for 2 days.
- Uncomplicated gonorrhoea: A single dose of 3 gm amoxicillin, with 1 gm probenecid.
- Prophylaxis of endocarditis: 2 — 3 gm is given about 1 hour before dental procedures.
- Eradication of H.pylori: E-MOX® is given with either metronidazole or clarithromycin and gastric secretion inhibitor or ranitidine, bismuth compound, in doses of 0.75 — 1.00 gm twice daily or 500 mg 3 times daily.
Reconstitution of E-MOX® Dry Mix
To make up, first shake the bottle to loosen powder, then add water to the content of the bottle and shake well. Fill up to the line and allow to stand for 5 minutes to ensure full dispersion.
After reconstitution, E-MOX® suspension should be stored in a refrigerator and used only within 10 days, Shake well before use.
Parenteral administration
- By IM or slow IV injection.
- Adults: 500 mg every 8 hours, In severe infections, 1 gm every 6 hours by slow IV injection over 3 — 4 minutes or by infusion over 30 — 60 minutes.
- Children aged up to 10 years: 50 — 100 mg/kg daily in divided doses.
- Doses may be reduced in renal impairment.
Side Effects
- As with other penicillins, side effects may include hypersensitivity (rash, anaphylaxis).
- superinfection, diarrhoea, nausea. vomiting, pseudomembranous colitis (rare), hemolytic anemia, eosinophilia, agranulocytosis (rare), pruritus. and urticaria.
E-MOX®- Information Leaflet
