Properties

Aspirin (acetyl salicylic acid) is a well-known analgesic, antipyretic, and anti-inflammatory agent. It produces analgesia through a peripheral action by blocking pain impulse generation and via a central action. The antipyretic effect is induced centrally on the hypothalamic heat-regulating centre. Both effects are mainly due to the inhibition of prostaglandins biosynthesis and other relevant mediators. Inhibition of cyclo-oxygenase is also the basis of the anti-inflammatory effect, in addition to the inhibition of leukocyte migration and the release and actions of lysosomal enzymes.

Disprin 81 also inhibits platelet aggregation by inhibiting cyclo oxygenase, thereby preventing the formation of the aggregating agent thromboxane A. To minimize the possible local gastric irritation, Disprin 81 tablets are enteric-coated tablets.

Indications

Disprin 81 is indicated as a platelet aggregation inhibitor to reduce the risk of myocardial infarction and transient ischemic attacks especially in men.

Dosage

The recommended dose of Disprin 81 as a platelet aggregation inhibitor is 1 To 4 tablets daily.
Disprin 81, being enteric-coated tablets, should be swallowed whole, and not chewed.

Note

Disprin 81 is not recommended for children below 12 years of age unless prescribed by a physician.

Contraindications

All medications containing aspirin are contraindicated in patients with a history of severe sensitivity to the active ingredient or other NSAIDs as well as in those having nasal polyps associated with asthma or thrombocytopenia.
It is better to avoid the concomitant administration of anticoagulants with salicylates as this may increase the risk of bleeding due to antiplatelet effect.
Patients with bleeding ulcers or hemophilia should not be given aspirin.
Aspirin should be avoided during lactation due to the possible risk of Reye’s syndrome to the infant.

Precautions

Caution is recommended when aspirin is given to patients with glucose-6-phosphate dehydrogenase deficiency, asthma, peptic ulcer, or gastritis.
Children and teenagers should not use this medicine for chicken pox or flu symptoms before consulting a physician about Reye’s syndrome, rare but serious illness.
During pregnancy, administering aspirin in low doses is probably not harmful, but it is better to be avoided unless the potential benefits outweigh the possible risks.

Side Effects

Disprin 81 is generally safe and well tolerated.
Some minor and transient side effects may be experienced including gastrointestinal irritation and hypersensitivity reactions.

Drug Interactions

It is better to avoid the concomitant use of this medicine with corticosteroids or with drugs for diabetes, gout, or arthritis unless directed by a physician.
As with other enteric-coated tablets, Disprin 81 tablets should not be taken concurrently with antacids; therefore, a time gap of one hour is recommended. In addition to this, antacids itself may increase the urinary excretion of salicylates, leading to a reduction in their plasma concentration upon concomitant use.

Presentation

Disprin 81 tablets: Pack of 40 tablets.

Composition

Disprin 81: Each enteric-coated tablet contains aspirin 81mg.

THIS IS A MEDICAMENT

Medicament is a product which affects your health. and its consumption contrary to instructions is dangerous for you.
Follow strictly the doctor’s prescription, the method of use and the instructions of the pharmacist who sold the medicament.
The doctor and the pharmacist are experts in medicines. their benefits and risks.
Do not by yourself interrupt the period of treatment prescribed for you.
Do not repeat the same prescription without consulting your doctor.
Keep all medicaments out of the reach of children.