Composition
Each tablet contains 40 mg or 80 mg gliclazide.
Pharmacological action
Diabetron® is an oral hypoglycemic which maintains the blood glucose level near the normal values throughout the day, and prevents hyperglycemia.
Diabetron® takes it hypoglycemic effect through:
1-Pancreatic action which occurs initially by increasing insulin production from functioning beta cells.
2-Extrapancreatic actions:
- Reduction of hepatic glucose production.
- Potentiation of insulin action on target tissues.
- Reduction of serum glucagon concentrations.
In addition to its hypoglycemic effect, Diabetron® has a beneficial effect on vascular complications caused by diabetes mellitus:
Diabetron® reduces platelet hyperaggregation and hyperadhesiveness, and restores the prostaglandin balance by increasing prostacyclin (vasodilator and antiaggregant) and decreasing thromboxane A2 (vasoconstrictor and proaggregatn).
Diabetron® normalizes vascular fibrinolytic activity and antagonizes vasoconstriction caused by adrenaline.
Therefore, Diabetron® has a beneficial effect on the prevention of diabetic micro-and macroangiopathy.
Indications
- Non insulin dependent diabetes mellitus which cannot be controlled by diet alone and/or accompanied by vascular complications
- Diabetes mellitus in the elderly
Contraindications
- Diabetic ketoacidosis
- Coma
- Pregnancy
- Precautions
- Care should be taken in patients with severe renal impairment.
- As with other hypoglycemic agents, care should be taken when using Diabetron® with anticoagulants. Hematological control should be frequent.
Side Effects
In rare cases, G.I.T. upset or skin rash may occur.
Dosage
40-80 mg daily, to be gradually increased, if necessary, up to 320 mg.
How Supplied
Strips of 10 scored tablets in packs of 2 strips.
Keep all medicaments out of reach of children
Product of: AMOUN PHARMACEUTICAL CO. El-Obour City, Cairo, Egypt. ATC Code: A10BB09