Circunex 1000 mg, Film-Coated Tablet – Venotonic & Vasculoprotector

Circunex is a venotonic (it increases the tone of the veins) and a vasculoprotector (it increases the resistance of small blood vessels).

This drug is recommended in the treatment of functional signs related to the hemorrhoidal crisis. If the hemorrhoidal disorders do not give way in 15 days, it is essential to consult your doctor.

Circunex is indicated, in adults, for the relief of symptoms related to mild venous insufficiency of the lower extremities, such as pain, heaviness, tightness and itching in the legs with varicose veins.

Circunex is often prescribed, together with other medicines, when treating the following conditions:

  • Acute haemorrhoid attacks.
  • Varicose veins, including spider capillaries.
  • Poor circulation in the legs (venous stasis).
  • Treating ulcers or sores in the leg due to blood flow problems (venous stasis ulcers).
  • Other diseases that occur as a result of poor peripheral circulation.

*You should see a doctor if it gets worse or if it doesn’t improve after 2 weeks.

*If a drug is approved for a single use, doctors may choose to use that same drug for other problems if they think it might be helpful, so your doctor may prescribe Circunex for treatment purposes other than those listed above.

How to Take Circunex 1000 mg, Film-Coated Tablet?

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if in doubt.

The recommended dose is 3 tablets per day for 4 days, then 2 tablets per day for the following 3 days at mealtimes.

For Chronic Venous Insufficiency in the Feet – Varicose Veins

*Important note: If the doses prescribed by your doctor are different from those mentioned in this page, ignore the information in this article and consult your doctor. If you are in doubt about the dose prescribed by your doctor, you can discuss it with him or ask the pharmacist for further guidance.

Initial dose: 1000 mg Diosmin, by mouth, two to three times daily (one tablet of Circunex 1000 mg three times daily), maintain this dose until symptoms and swelling are completely gone. Symptoms usually disappear after two weeks of starting treatment, and then switching to the maintenance dose.

Maintenance dose: To enhance the results of treatment, continue treatment with the maintenance dose: of 1000 mg Diosmin (one tablet) once a day, for 2 months.

If symptoms reappear again, the same dosing regimen can be repeated. If symptoms do not improve or get worse after two weeks of starting treatment, stop treatment and talk to your doctor.

This medicine is not suitable for children under 18 years of age.

It is not recommended to take Circunex for more than three months without medical supervision.

If you take more Circunex than you should: Immediately consult your doctor or pharmacist. Data regarding overdose with Circunex are limited but reported symptoms include: diarrhoea, nausea, abdominal pain, pruritus and rash.

Children and Teenagers

It should not be used in children and adolescents (under 18) unless directed by your doctor.

Instructions for Good Preparation Management

Once removed from the blister, the tablet should be swallowed directly. It can be accompanied by water or another drink to facilitate swallowing.

If you take more Circunex than you should: In case of overdose or accidental ingestion, immediately consult your doctor or pharmacist or go to a medical center, or call the Toxicological Information Service, indicating the drug and the quantity ingested.

If you forgot to take Circunex: Take the missed dose as soon as you remember, however, if you are nearing the time to take the next dose, skip the missed dose.

Warnings and Precautions

Children and teenagers: Circunex should not be used in children and adolescents unless instructed by your doctor.

Taking Circunex with other medications: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines taken without a prescription. There are no known interactions with other medicines, in any case you should never take another medicine on your own without your doctor recommending it.

Take Circunex with food: There are no known interactions with food.

Do not take Circunex: If you are allergic to Diosmin or any of the other ingredients of this medicine.

Pregnancy and Lactation

If you are pregnant or breastfeeding, think you may be pregnant or intend to become pregnant, talk to your doctor or pharmacist before using this medicine.

No clinical data are available on the use of Diosmin in pregnant women. As a precautionary measure, the use of Circunex during pregnancy is not recommended unless the potential benefits outweigh the potential risks… As a precautionary measure, it is preferable to avoid the use of Circunex during pregnancy.

No clinical data are available on the use of Diosmin in nursing women. It is not known whether Diosmin passes into breast milk, so its use during lactation is not recommended.

Driving and Using Machines

Circunex has no influence on the ability to drive and use machines.

What Are the Possible Side Effects?

Like all medicines, this medicine can cause side effects, although not everyone gets them.

The frequency of possible side effects listed below is defined using the following system:

  • very common (affects more than 1 user in 10)
  • common (affects 1 to 10 users in 100)
  • uncommon (affects 1 to 10 users in 1,000)
  • rare (affects 1 to 10 users in 10,000)
  • very rare (affects less than 1 user in 10,000)
  • frequency unknown (the available data do not allow an estimation of the frequency)

They may include:

  • Common: diarrhoea, dyspepsia, nausea, vomiting.
  • Uncommon: colitis.
  • Rare: dizziness, headache, malaise, rash, pruritus, urticaria.
  • Unknown frequency: abdominal pain, isolated edema of the face, eyelids, lips.
  • Exceptionally: angioedema.

Declaration of side effects: If you get any side effects, talk to your doctor or pharmacist. This also applies to any adverse effects not mentioned in this page. You can also report adverse effects directly via the national reporting system (Pharmacovigilance Center in food & drug adminstration) at your country.

By reporting side effects, you help provide more information about the safety of the medicine.

CAUTION: It is not recommended to take Circunex for more than three months without medical supervision.

Circunex May Interact With Other Health Problems

Circunex may interact with your health condition. This interaction may worsen your health condition or change the way the medicine works. It is important to always inform your doctor and pharmacist of all health problems you currently have, especially:

  • Hyperthyroidism.
  • cerebral edema;
  • Epilepsy.
  • Severe arterial hypertension.
  • Coronary insufficiency.
  • hepatic insufficiency.
  • obesity.
  • Ulcers of the stomach and duodenum.

Other Information

  • ATC code: C05CA53.
  • Pharmacological class: Capillary Stabilizing Agents
  • Chemical Class: Bioflavonoids
  • Legal: Prescription- Uncontrolled Human Medications

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

How to Store Circunex 1000 MG, Film-Coated Tablet?

Keep this medication out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the box. The expiry date refers to the last day of that month.

Do not dispose of any medicine via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.


Each Circunex 1000 mg, film-coated tablet contains: 1000 mg of Micronized purified flavonoid fraction, Corresponding to :

  • Diosmin 90 % (900 mg).
  • Flavonoids expressed as hesperidin 10 % (100 mg).