CELEBREX: A User’s Guide to Indications and Dosage

If you’ve been prescribed CELEBREX (celecoxib) and want to understand how to use it effectively, this guide provides essential information in a simple, straightforward manner. Before starting the medication, it’s crucial to grasp its indications and appropriate dosages. Remember, this guide doesn’t replace the advice of your healthcare professional. If you have any concerns, consult with your doctor or pharmacist.


What CELEBREX Is and How It Works

CELEBREX, available in 100 mg and 200 mg hard capsules, is used in adults for the following purposes:

  • Relief of Symptoms: CELEBREX is utilized for relieving symptoms and providing symptomatic treatment for three specific conditions:
    • Rheumatoid Arthritis
    • Osteoarthritis
    • Ankylosing Spondylitis

Understanding Its Mechanism

CELEBREX belongs to a category of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs). It is a selective cyclooxygenase-2 (COX-2) inhibitor. The body produces prostaglandins that can cause pain and inflammation. During inflammatory processes, such as in rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis, the synthesis of prostaglandins increases. CELEBREX works by reducing the release of prostaglandins, thereby reducing pain and inflammation.

Time to Effect

You should experience the effects of CELEBREX within a few hours after taking the first dose, although the full benefits may take several days to manifest.


What You Need to Know Before Using CELEBREX

Your healthcare provider will prescribe the appropriate CELEBREX dosage for you. Understanding the following information will help you use the medication safely and effectively:

1. Do Not Use CELEBREX in These Situations:

Inform your doctor if any of the following conditions apply to you, as they are contraindications for using CELEBREX:

  • Allergic to celecoxib or any other component of the medicine.
  • Allergic to sulfonamide group medicines (e.g., certain antibiotics).
  • Current stomach ulcer, intestinal ulcer, or gastrointestinal bleeding.
  • Asthma, nasal polyps, or severe allergic reactions after taking certain drugs (e.g., acetylsalicylic acid or NSAIDs).
  • Pregnancy or planning pregnancy.
  • Breastfeeding.
  • Severe liver or kidney disease.
  • Inflammatory bowel disease.
  • Heart conditions or previous blood circulation problems.

2. Warnings and Precautions for Use:

Before starting CELEBREX, consult your doctor or pharmacist if you:

  • Had prior stomach or gastrointestinal issues.
  • Are taking acetylsalicylic acid or other medications.
  • Are on anticoagulants (e.g., warfarin).
  • Use corticosteroids.
  • Take other NSAIDs (e.g., ibuprofen or diclofenac).
  • Smoke, have diabetes, high blood pressure, or high cholesterol.
  • Have heart, liver, or kidney problems.
  • Experience fluid retention or dehydration.
  • Previously had severe allergic reactions or skin issues.
  • Feel unwell or suspect an infection.
  • Are over 65 years old.

3. Use in Children:

CELEBREX is meant for adult use only and is not suitable for children.

4. Pregnancy, Breastfeeding, and Fertility:

  • CELEBREX is not recommended during pregnancy or breastfeeding.
  • It may affect fertility, so consult a healthcare provider if you plan to become pregnant or encounter fertility issues.

Dosage Recommendations:

Your doctor will specify the appropriate CELEBREX dose. It’s important to use the lowest effective dose to control pain and not to take CELEBREX for longer than needed. The method of use is oral.


  • Recommended: 200 mg daily, may increase to a maximum of 400 mg if necessary.
  • Usual: One 200 mg capsule once a day or one 100 mg capsule twice a day.

Rheumatoid Arthritis:

  • Recommended: 200 mg daily, may increase to a maximum of 400 mg if necessary.
  • Usual: One 100 mg capsule twice a day.

Ankylosing Spondylitis:

  • Recommended: 200 mg daily, may increase to a maximum of 400 mg if necessary.
  • Usual: One 200 mg capsule once a day or one 100 mg capsule twice a day.

Special Cases:

  • Kidney or liver problems: Lower doses may be required.
  • Elderly patients under 50 kg: Close monitoring may be necessary.

Do not exceed 400 mg per day.

5. How to Take CELEBREX:

  • CELEBREX can be taken at any time of the day, with or without food.
  • If you have difficulty swallowing the capsule, its contents can be mixed with a small amount of soft food, followed by a glass of water.
  • Do not chew or crush the granules.

6. What If You Forget or Need to Stop CELEBREX:

If you miss a dose, take it as soon as you remember. Never double the dose to compensate. Do not discontinue CELEBREX without your doctor’s guidance.

This article provides clear and concise information about CELEBREX, its indications, and the recommended dosages. Always consult your healthcare provider for personalized guidance and additional details.

Possible Side Effects

CELEBREX, like all medications, can have side effects. While not everyone will experience them, it’s essential to be aware of potential issues. If you encounter any side effects, consult your doctor or pharmacist.

Common side effects include:

  • Increased blood pressure, heart attack, fluid retention, urinary tract infections, and shortness of breath.
  • Gastrointestinal symptoms like vomiting, stomach pain, and diarrhea.
  • Skin reactions such as rashes and itching.
  • Dizziness, sleep disturbances, and headache.

Other side effects, though less common, may also occur. Some of these can be more severe. If you experience severe side effects, such as allergic reactions, heart problems, liver or skin issues, or stomach bleeding, contact your doctor immediately.

It’s crucial to remember that CELEBREX, like any medication, may have side effects. If you notice any unexpected symptoms or are concerned about your health, consult your healthcare provider for guidance.

Reporting Side Effects

You can report any side effects directly to the State Agency of Medicines. By doing so, you contribute to the safety of medications for all patients. Your health is of utmost importance, and your feedback matters.

In summary, CELEBREX is a valuable medication for managing arthritis and associated conditions. Understand its purpose and proper usage, consult your healthcare provider for personal recommendations, and be vigilant about potential side effects for a safe and effective treatment experience.