Casodex 150 mg: A Comprehensive Guide

Are you or a loved one facing the challenge of locally advanced prostate cancer? In this article, we delve into the specifics of Casodex 150 mg, a medication that plays a vital role in managing this condition.

Qualitative and Quantitative Composition

Each tablet of Casodex 150 mg contains 150 mg of bicalutamide. This active ingredient is crucial in the treatment of prostate cancer.

Pharmaceutical Form

Casodex 150 mg is presented in the form of white film-coated tablets. These tablets are designed for oral administration.

Therapeutic Indications

Casodex 150 mg is recommended for use either as a standalone treatment or as an adjuvant to radical prostatectomy or radiotherapy. It is prescribed for patients with locally advanced prostate cancer at high risk for disease progression. Casodex 150 mg also comes into play for the management of patients with locally advanced, non-metastatic prostate cancer when surgical castration or other medical intervention is not considered appropriate or acceptable.

Posology and Method of Administration

  • Adult males, including the elderly, should take one 150 mg tablet of Casodex orally once a day.
  • Casodex 150 mg should be taken continuously for at least two years or until disease progression.

Patients with renal impairment generally do not require dosage adjustments. However, for those with hepatic impairment, caution is necessary, and patients with moderate to severe hepatic impairment may experience increased accumulation of bicalutamide.

Contraindications

Casodex 150 mg is contraindicated in females and children. It must not be administered to patients who have shown hypersensitivity to the active substance or any of the product’s excipients. Co-administration of certain drugs like terfenadine, astemizole, or cisapride with Casodex is also contraindicated.

Special Warnings and Precautions for Use

  • The initiation of Casodex 150 mg treatment should be under the direct supervision of a specialist.
  • Bicalutamide is metabolized in the liver, which may lead to increased accumulation in patients with severe hepatic impairment. Hence, caution is necessary for such patients.
  • Periodic liver function testing should be considered due to the possibility of hepatic changes. Severe hepatic changes and hepatic failure, though rare, have been observed with Casodex 150 mg.
  • Photosensitivity reactions have been reported in some cases, so patients should avoid direct exposure to excessive sunlight or UV-light.
  • Lactose-sensitive patients should be aware that each Casodex 150 mg tablet contains lactose monohydrate.
  • Patients with rare hereditary problems related to lactose intolerance should not take this medicine.
  • Androgen deprivation therapy may prolong the QT interval, so the concomitant use of Casodex with certain drugs known to prolong the QT interval should be carefully evaluated.
  • Antiandrogen therapy may cause morphological changes in spermatozoa, requiring adequate contraception during and for 130 days after Casodex therapy.
  • There are interactions with certain drugs, including anticoagulants, that can affect blood clotting. Close monitoring and dose adjustments should be considered.

Interaction with Other Medicinal Products

Casodex interacts with various drugs, including inhibitors of cytochrome P450 (CYP 3A4). This interaction can affect the metabolism of co-administered drugs, so caution is necessary. Additionally, the interaction with coumarin anticoagulants can result in increased Prothrombin Time and International Normalized Ratio, potentially leading to a risk of bleeding.

Fertility, Pregnancy, and Lactation

  • Bicalutamide is contraindicated during pregnancy, and pregnant women should not use it.
  • It’s also contraindicated during breastfeeding, as it can be excreted in breast milk.
  • In animal studies, bicalutamide has shown reversible impairment of male fertility.

Pharmacological Properties

Casodex 150 mg is an antiandrogen that inhibits the androgen stimulus and causes regression of prostatic tumors. The drug’s effectiveness depends on the patient’s risk factors for disease progression.

Pharmacokinetic Properties

Bicalutamide is well absorbed when taken orally and has a long half-life. It is mainly eliminated through the liver, and its pharmacokinetics are not significantly affected by age or renal impairment. In severe hepatic impairment, however, the elimination process can slow down.

Pre-Clinical Safety Data

Pre-clinical studies indicate that bicalutamide may cause atrophy of seminiferous tubules and other organ changes in animals. However, these effects have not been observed in humans.

List of Excipients

Casodex 150 mg includes various excipients that play a role in the composition of the tablet. These include lactose monohydrate, magnesium stearate, povidone, carboxymethyl amidon sodium, hypromellose, macrogol 300, and titanium dioxide.

Casodex 150 mg – Patient Information Leaflet

Special Precautions for Storage

Casodex 150 mg should be stored at temperatures not exceeding 30°C to maintain its efficacy.

Remember that any medical treatment should always be administered under the guidance and supervision of a healthcare specialist. Patients should communicate with their doctors to ensure the most effective and safe management of their condition. This guide provides an overview of Casodex 150 mg to help patients and their families make informed decisions about their treatment. Always seek professional medical advice tailored to your specific situation.

كاسوديكس أقراص فموية – أورام البروستاتا المتقدمة