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Burinex® Leo – Short-acting diuretic

Burinex® Leo – Short-acting diuretic

Burinex is indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome.

Burinex Tablets: Bumetanide 1 mg and 5 mg.

Properties

Burinex is a potent highceiling diuretic with a rapid onset and a short duration of action. After oral administration, Burinex is well absorbed and the diuresis begins within 30 minutes with a peak effect between 1 and 2 hours. After a dose of 1 mg, the diuretic effect is virtually complete in 3 hours. The short action minimizes disturbances in the patient’s daily routine and allows an individual timing of the diuresis according to the needs of the patient.

The diuretic effect of Burinex is dose-related so that patients, failing to respond to a low initial dose, may respond to higher doses. Burinex has been shown to exert its major effect in the ascending limb of the loop of Henle, but it may also have an additional action in the proximal tubule. Clinical investigations have shown that Burinex is reliably effective and well tolerated.

 

Indications

Burinex is indicated whenever diuretic therapy is required in the treatment of oedema e.g. :

  • associated with congestive heart failure.
  • cirrhosis of the liver.
  • renal diseases including the nephrotic syndrome.
  • Acute pulmonary oedema.
  • drug-induced fluid retention

Burinex is indicated to manage:

  • drug poisoning that can be treated by forced diuresis.
  • Hypertension.

Dosage

  • Orally: 1 tablet daily.
  • In refractory cases the dose can be increased gradually till a satisfactory response has been obtained. Rarely it will be necessary to exceed a dose of 4 mg daily.
  • The 5 mg tablet is for use in resistant oedema due to renal insufficiency and where higher doses are required.
  • In high dose therapy consideration should be given to a twice daily dosing.
  • Children: The dose is calculated on the basis of 0.03 – 0.06 mg / kg daily.
  • Elderly: Adjust dosage according to response: a dose of 0. 5 mg daily may be sufficient in some elderly patients.
Burinex® Leo - Short-acting diuretic
Burinex® Leo – Short-acting diuretic

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